TG100-115 CAS: 677297-51-7
MF: C18H14N6O2
MW: 346.34
A PI3K and FRAP inhibitor with some action against Akt.

TG100-115 (CAS 677297-51-7)

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Alternate Names: 6,7-Bis(3-hydroxyphenyl)pteridine-2,4-diamine
Application: TG100-115 is a PI3K and FRAP inhibitor with some action against Akt
CAS Number: 677297-51-7
Purity: ≥98%
Molecular Weight: 346.34
Molecular Formula: C18H14N6O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

TG100-115 inhibits PI 3-kinase p110 γ and PI 3-kinase p110 δ (PI3Kγ and -δ), with IC50 of 83 and 235 nM, respectively. TG100-115 is not active for PI3Kα and -β, with IC50 of 1.2 and 1.3 mM. TG100-115 (10 μM) interrupts other VEGF signaling pathways, such as those that culminate in VE-cadherin phosphorylation. In HUVECs, TG100-115 (10 μM) inhibits the VEGF-induced increase of total level of VE-cadherin. TG100-115 inhibits VEGF mediated phosphorylation of mTOR, also known as FRAP, and p70S6 kinase, both of which are downstream of PI3K. TG100-115 (125 nM to 10 μM) also inhibits FGF-stimulated phosphorylation of Akt.

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Physical State :
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Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
10427712
SMILES :
C1=CC(=CC(=C1)O)C2=NC3=C(N=C2C4=CC(=CC=C4)O)N=C(N=C3N)N

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Certificate of Analysis

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