BKM120 CAS: 944396-07-0
MF: C18H21F3N6O2
MW: 410.39
A PI 3-kinase family inhibitor.

BKM120 (CAS 944396-07-0)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 100ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Alternate Names: NVP-BKM120; Buparlisib; 5-(2,6-di-4-Morpholinyl-4-pyrimidinyl)-4-(trifluoromethyl)-2-pyridinamine
Application: BKM120 is BKM120 is a PI 3-kinase family inhibitor
CAS Number: 944396-07-0
Purity: ≥98%
Molecular Weight: 410.39
Molecular Formula: C18H21F3N6O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

BKM120 is a potent and cell permeable inhibitor of the PI 3-kinase family. Specifically inhibits p110α, p110β, p110γ and p110δ with IC50 of 52 nM, 166 nM, 262 nM and 116 nM, respectively.

Appearance :
Physical State :
Solubility :
Soluble in water (<1 mg/ml), DMSO (82 mg/ml), and ethanol (2 mg/ml).
Storage :
Store at -20° C
Melting Point :
218.91° C (Predicted)
Boiling Point :
580.70-710.70° C at 760 mmHg (Predicted)
Density :
1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.57 (Predicted)
IC50 :
p110δ: IC50 = 116 nM; p110β: IC50 = 166 nM; p110γ: IC50 = 262 nM; p110α: IC50 = 52-99 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

BKM120 (CAS 944396-07-0)  Product Citations

See how others have used BKM120 (CAS 944396-07-0). Click on the entry to view the PubMed entry .

Citations 1 to 8 of 8 total

PMID: # 31119683  Tsuboi, K.|Uematsu, C.|Yamaguchi, Y.|Niwa, T.|Hayashi, SI.| et al. 2019. Breast Cancer.

PMID: # 25902041  Huang, C. et al. 2015. Int. J. Mol. Med. 36: 239-48.

PMID: # 25760103  You, Y. et al. 2015. Mol Med Rep. 12: 255-60.

PMID: # 26297436  Jung, IH. et al. 2015. Neoplasia. 17: 586-97.

PMID: # 25323007  Wang, J. et al. 2014. Oncol. Rep. 32: 2557-63.

PMID: # 25245332  Wu, L. et al. 2014. Tumour Biol. 35: 12327-37.

PMID: # 23924390  Fekete, A. et al. 2013. Journal of molecular signaling. 8: 8.

PMID: # 32092966  Cancers (Basel). 12:

Citations 1 to 8 of 8 total

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. BKM120, sc-364437, is in white powder form.
Answered by: Chemical Support 4
Date published: 2017-05-05

What is the desired solvent of this chemical?

Asked by: two2igm05
Thanks for your question. BKM120, sc-364437, is soluble in DMSO at 82 mg/mL (199 mM), Water at &lt;1 mg/mL (&lt;1 mM), and Ethanol at 2 mg/mL (4 mM).
Answered by: TechService7
Date published: 2016-12-15
  • y_2020, m_11, d_27, h_16CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.12
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_2
  • loc_en_US, sid_364437, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 79ms
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 8ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.