Molecular structure of SF1126, CAS Number: 936487-67-1
SF1126 (CAS 936487-67-1)
See product citations (7)
Alternate Names:
(8S,14S,17S)-14-(carboxymethyl)-8-(3-guanidinopropyl)-17-(hydroxymethyl)-3,6,9,12,15-pentaoxo-1-(4-(4-oxo-8-phenyl-4H-chromen-2-yl)morpholino-4-ium)-2-oxa-7,10,13,16-tetraazaoctadecan-18-oate
Application:
SF1126 is a prodrug containing the pan-PI3K/mTOR inhibitor LY294002/SF1101
CAS Number:
936487-67-1
Purity:
≥98%
Molecular Weight:
852.84
Molecular Formula:
C39H48N8O14
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
SF1126 is a water soluble, small-molecule prodrug containing the pan-PI3K/mTOR inhibitor LY294002/SF1101 conjugated to the RGD-containing tetra-peptide SF1174 with potential antineoplastic and antiangiogenic activities. The SF1126 is designed to remain stable at acidic pH (pH < 5) and to spontaneously hydrolyze at physiologic pH. The spontaneous cleavage of SF1126 is determined at pH 7.0 in vitro. SF1126 selectively binds to cell surface integrins and, upon cell entry, the agent is hydrolyzed to the active drug SF1101. By inhibiting the PI3K signaling pathway, this agent may inhibit tumor cell and tumor endothelial cell proliferation and survival.
Inhibitor of:
Brn-2, Brn-3b, Enzyme, mTOR, p13, PI 3-kinase, PI 3-kinase p100, PI 3-kinase p101, PI 3-kinase p110, PTEN, and SNX31.Activator of:
SSBP2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SF1126, 5 mg | sc-391584 | 5 mg | $1050.00 | |||
SF1126, 10 mg | sc-391584A | 10 mg | $2240.00 |