OBFC1 Inhibitors
OBFC1 inhibitors belong to a specialized class of chemical compounds designed to target the OBFC1 (Oligonucleotide/oligosaccharide-binding fold containing 1) protein. OBFC1 is a multifunctional protein that plays a significant role in maintaining genomic stability and regulating various aspects of DNA metabolism. It is an integral component of the shelterin complex, which protects the ends of chromosomes, known as telomeres, from degradation and aberrant repair processes. Telomeres are essential for preserving genomic integrity and preventing DNA damage response pathways from being inappropriately activated. OBFC1 functions by binding to the single-stranded overhang of telomeric DNA and facilitating the recruitment of other shelterin components, thereby contributing to telomere maintenance and chromosome end protection.
Inhibitors targeting OBFC1 are designed to interact with this protein and potentially disrupt its association with telomeric DNA or other shelterin components. These inhibitors may operate through various mechanisms, such as binding to OBFC1's oligonucleotide/oligosaccharide-binding fold domain or altering its conformation. By inhibiting OBFC1, these compounds can potentially affect telomere maintenance and chromosome end protection, ultimately influencing genomic stability and cellular processes related to DNA metabolism. Research on OBFC1 inhibitors is primarily focused on elucidating the molecular mechanisms by which OBFC1 participates in telomere regulation and genomic stability, providing valuable insights into fundamental cellular processes related to DNA integrity and genome maintenance.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $95.00 $322.00 $663.00 $1438.00 | 6 | |
An antibiotic that inhibits bacterial RNA polymerase, potentially affecting transcription of certain human genes. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Known to intercalate into DNA and alter gene expression, it could affect OBFC1 expression. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
A topoisomerase I inhibitor that could induce DNA damage response pathways, potentially impacting OBFC1 expression. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $254.00 | 41 | |
A cyclin-dependent kinase inhibitor that may alter cell cycle progression and gene expression patterns, including OBFC1. | ||||||
Rocaglamide | 84573-16-0 | sc-203241 sc-203241A sc-203241B sc-203241C sc-203241D | 100 µg 1 mg 5 mg 10 mg 25 mg | $270.00 $465.00 $1607.00 $2448.00 $5239.00 | 4 | |
A natural product that has been shown to inhibit translation and could affect mRNA levels of certain proteins. | ||||||
1-β-D-Arabinofuranosylcytosine | 147-94-4 | sc-201628 sc-201628A sc-201628B sc-201628C sc-201628D | 1 g 5 g 25 g 100 g 250 g | $147.00 $258.00 $508.00 $717.00 $1432.00 | 1 | |
A nucleoside analog that interferes with DNA synthesis, potentially affecting the expression of genes like OBFC1. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
A topoisomerase II inhibitor that can lead to altered transcriptional profiles, potentially affecting OBFC1 expression. | ||||||
Homoharringtonine | 26833-87-4 | sc-202652 sc-202652A sc-202652B | 1 mg 5 mg 10 mg | $51.00 $123.00 $178.00 | 11 | |
An alkaloid that has been observed to inhibit protein synthesis at the level of translation, which could reduce OBFC1 levels. | ||||||
Mitoxantrone | 65271-80-9 | sc-207888 | 100 mg | $279.00 | 8 | |
An anthracenedione that intercalates into DNA and disrupts transcription and replication processes. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
A potent inhibitor of RNA polymerase II which can suppress mRNA synthesis, potentially reducing OBFC1 expression. | ||||||