1-β-D-Arabinofuranosylcytosine, a cytosine analogue, inhibits DNA polymerases α, δ, and ε, and RNA polymerases resulting in suppression of DNA synthesis and repair. 1-β-D-Arabinofuranosylcytosine acts as an antimetabolic agent which is responsible for damaging DNA during the S-phase of the cell cycle. In addition, 1-β-D-Arabinofuranosylcytosine inhibits nucleotide reductase enzymes that are needed for DNA synthesis to occur. Alternate studies suggest that 1-β-D-Arabinofuranosylcytosine is clastogenic to both spermatogonial cells and bone marrow. Furthermore, 1-β-D-Arabinofuranosylcytosine can be used to control the proliferation of glial cells.
1. Furth, J.J. and Cohen, S.S. 1968. Cancer Res. 28: 2061-2067. PMID: 5754840 2. Kligerman, A.D., et al. 1999. Mutat. Res. 444: 151-158. PMID: 10477349 3. Palo, A.K., et al. 2009. Mutat. Res. 673: 29-36. PMID: 19095079
Soluble in water (1:10), DMSO (1 mg/mL) at 25° C, ethanol ( <1 mg/mL) at 25° C, chloroform (1g in 1L chloroform), and methanol (1g in 300 ml methanol ).
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An increase in cleaved caspaseAn increase in cleaved caspase-8 was observed by WB when comparing untreated Jurkat cells with those that have been treated with 1- -D-Arabino furanosylcytosine. -SCBT QC
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