NuMA Inhibitors
The chemical class of NuMA inhibitors consists of compounds that affect various stages of cell division by disrupting the mitotic spindle, a structure crucial for the accurate segregation of chromosomes. These inhibitors act on different targets within the cell, such as tubulin, mitotic kinesins, and kinases, which are fundamental in the establishment and function of the spindle apparatus. Although not directly targeting NuMA, the inhibition of these targets ultimately leads to the indirect disruption of NuMA function. Microtubule-targeting agents like Colchicine, Nocodazole, and Griseofulvin affect NuMA by destabilizing the very microtubules that NuMA associates with to form and maintain the spindle poles. Mitotic kinesin inhibitors such as Monastrol and S-Trityl-L-cysteine disrupt spindle pole formation, which NuMA is a critical part of. The function of NuMA is contingent upon the precise control and progression of the cell cycle, which is modulated by CDKs. Inhibitors like Alsterpaullone and Purvalanol A compromise NuMA's activity by disrupting these regulatory pathways.
Plk1 and Aurora kinase inhibitors, such as BI 2536 and ZM447439, respectively, impede spindle assembly and checkpoint functions, essential processes that NuMA is involved in. Disruption of these processes can lead to mitotic errors, with consequences for cell viability and proliferation. High doses of Paclitaxel, which is known to stabilize microtubules, can also be considered a NuMA inhibitor as it disrupts the dynamic function of microtubules necessary for the proper operation of NuMA. In summary, NuMA inhibitors encompass a diverse array of chemical entities that interfere with mitotic spindle dynamics, kinases, and regulatory proteins involved in cell cycle progression. Their modes of action, though varied, converge on the impairment of NuMA function during cell division, highlighting the intricate network of cellular processes that NuMA is integral to.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine binds to tubulin, inhibiting its polymerization into microtubules, thus disrupting microtubule formation. This destabilization of microtubules can interfere with the function of NuMA in spindle assembly and maintenance, leading to mitotic arrest and potentially causing the aberrant distribution or mislocalization of NuMA during cell division. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole is a synthetic compound that disrupts microtubule dynamics by inhibiting tubulin polymerization. NuMA's function is intimately connected to microtubules; nocodazole's effect can lead to the misregulation of NuMA, causing defects in spindle assembly and chromosome segregation during mitosis. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $83.00 $216.00 $586.00 | 4 | |
Griseofulvin interferes with microtubule function by binding to polymerized microtubules and can disrupt mitotic spindle organization. This disruption can impede the proper localization and function of NuMA at the spindle poles, which is critical for cell division. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Monastrol is a small molecule inhibitor of the mitotic kinesin Eg5, which affects spindle pole separation. Inhibition of Eg5 can lead to monopolar spindle formation, indirectly affecting NuMA function by preventing its proper localization and consequent spindle assembly, critical for successful mitosis. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $31.00 $65.00 | 6 | |
S-Trityl-L-cysteine is a selective Eg5 inhibitor that impedes the proper formation of the bipolar spindle apparatus. NuMA's role in spindle assembly is compromised without functional Eg5, as NuMA requires a bipolar spindle to ensure correct attachment and alignment of chromosomes. | ||||||
Thiabendazole | 148-79-8 | sc-204913 sc-204913A sc-204913B sc-204913C sc-204913D | 10 g 100 g 250 g 500 g 1 kg | $31.00 $82.00 $179.00 $306.00 $561.00 | 5 | |
Thiabendazole inhibits microtubule assembly, impacting mitotic spindle formation. By destabilizing microtubules, it indirectly hampers NuMA's role in organizing and stabilizing the spindle poles during mitosis, leading to cell cycle arrest and mitotic failure. | ||||||
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $67.00 $306.00 | 2 | |
Alsterpaullone is a cyclin-dependent kinase inhibitor that can disrupt cell cycle progression. By inhibiting CDK1, alsterpaullone may impair the phosphorylation and, therefore, the function of NuMA, which is necessary for its role in spindle assembly during mitosis. | ||||||
Purvalanol A | 212844-53-6 | sc-224244 sc-224244A | 1 mg 5 mg | $71.00 $291.00 | 4 | |
Purvalanol A is a potent inhibitor of cyclin-dependent kinases. By inhibiting CDK1, it can suppress the phosphorylation state of NuMA, which is required for its function during spindle assembly in mitosis. | ||||||
BI 2536 | 755038-02-9 | sc-364431 sc-364431A | 5 mg 50 mg | $148.00 $515.00 | 8 | |
BI 2536 is a Plk1 inhibitor that leads to spindle assembly defects. Plk1 is involved in the regulation of mitotic entry and spindle assembly; its inhibition by BI 2536 can indirectly affect NuMA's role in spindle pole organization and maintenance, which is critical for mitotic progression. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
ZM447439 is an Aurora kinase inhibitor that can disrupt chromosome alignment and segregation. Aurora kinase activity is crucial for spindle checkpoint functions and NuMA localization; thus, its inhibition can result in the improper function of NuMA in the spindle assembly checkpoint, leading to mitotic errors. | ||||||