S-Trityl-L-cysteine is a cell-permeable cysteine thioether compound that exhibits antitumor and antimitotic properties by inhibiting mitotic kinesin Eg5. S-Trityl-L-cysteine has been found to potently block that basal and microtubule-activated mitotic spindle kinesin ATPase activities. S-Trityl-L-cysteine has been shown to be 36-fold more potent than Monastrol (sc-202710) for inducing mitotic arrest in HeLa cells.
1. Brier, S., et al. 2004. Biochemistry. 43: 13072-13082. PMID: 15476401 2. DeBonis, S., et al. 2004. Mol. Cancer Ther. 3: 1079-1090. PMID: 15367702 3. Shimizu, M., et al. 2010. Bioorg. Med. Chem. Lett. 20: 1578-1580. PMID: 20138511
Soluble in water (partly), DMSO (5 mg/ml), and methanol.
Store at -20° C
182-183° C (lit.)(dec.)
524.75° C at 760 mmHg (Predicted)
1.23 g/cm3 (Predicted)
n20D 1.64 (Predicted)
α20/D +84°, c = 1 in acetic acid; α25/D +115°, c = 0.8 in 0.04 M ethanolic HCl; α20/D +74.8°, c = 1 in methanol; α20/D +110°±5°, c = C=0.8 in 0.04 M HCl(EtOH)
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DeBonis et alDeBonis et al. (PubMed ID 15367702) found that S-Trityl-L-cysteine was an effective Eg5 and ATPase inhibitor that also induced mitotic arrest in HeLa cells. -SCBT Publication Review
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