Molecular structure of Monastrol, CAS Number: 254753-54-3
Monastrol (CAS 254753-54-3)
See product citations (10)
Alternate Names:
4-(3-Hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4H-pyrimidin-5-carboxylic acid ethyl ester
Application:
Monastrol is a kinesin Eg5 inhibitor which arrests cells in mitosis
CAS Number:
254753-54-3
Purity:
≥95%
Molecular Weight:
292.35
Molecular Formula:
C14H16N2O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Monastrol is extensively used in cell biology research, particularly for its role in inhibiting kinesin Eg5, a motor protein that is essential for spindle formation during cell division. This inhibition makes Monastrol useful for studying mitosis and understanding the mechanisms of spindle dynamics. Researchers employ Monastrol to induce mitotic arrest, thereby facilitating detailed studies of chromosome alignment and segregation. Additionally, Monastrol is utilized in investigations into the development of anti-mitotic compounds, which are of interest for their potential to modulate cell proliferation. The insights gained from studies using Monastrol contribute significantly to the broader understanding of cell cycle regulation and the potential for targeting specific proteins in the study of cellular division processes.
Monastrol (CAS 254753-54-3) References
- Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. | Mayer, TU., et al. 1999. Science. 286: 971-4. PMID: 10542155
- A combinatorial approach to recognition of chirality: preparation of highly enantioselective aryl-dihydropyrimidine selectors for chiral HPLC. | Lewandowski, K., et al. 1999. J Comb Chem. 1: 105-12. PMID: 10746018
- Evidence that monastrol is an allosteric inhibitor of the mitotic kinesin Eg5. | Maliga, Z., et al. 2002. Chem Biol. 9: 989-96. PMID: 12323373
- Inhibition of a mitotic motor protein: where, how, and conformational consequences. | Yan, Y., et al. 2004. J Mol Biol. 335: 547-54. PMID: 14672662
- Monastrol inhibition of the mitotic kinesin Eg5. | Cochran, JC., et al. 2005. J Biol Chem. 280: 12658-67. PMID: 15665380
- Monastrol, a selective inhibitor of the mitotic kinesin Eg5, induces a distinctive growth profile of dendrites and axons in primary cortical neuron cultures. | Yoon, SY., et al. 2005. Cell Motil Cytoskeleton. 60: 181-90. PMID: 15751098
- Interaction of the mitotic kinesin Eg5 inhibitor monastrol with P-glycoprotein. | Peters, T., et al. 2006. Naunyn Schmiedebergs Arch Pharmacol. 372: 291-9. PMID: 16365780
- A pathway of structural changes produced by monastrol binding to Eg5. | Maliga, Z., et al. 2006. J Biol Chem. 281: 7977-82. PMID: 16434397
- Allosteric inhibition of kinesin-5 modulates its processive directional motility. | Kwok, BH., et al. 2006. Nat Chem Biol. 2: 480-5. PMID: 16892050
- Centrin: another target of monastrol, an inhibitor of mitotic spindle. | Duan, L., et al. 2015. Spectrochim Acta A Mol Biomol Spectrosc. 137: 1086-91. PMID: 25300040
- Antiproliferative activity of monastrol in human adenocarcinoma (MCF-7) and non-tumor (HB4a) breast cells. | Marques, LA., et al. 2016. Naunyn Schmiedebergs Arch Pharmacol. 389: 1279-1288. PMID: 27592117
- Comparison of the Effects of Monastrol and Oxomonastrol on Human Hepatoma Cell Line HepG2/C3A. | Marques, LA., et al. 2017. Anticancer Res. 37: 1197-1204. PMID: 28314282
- Fatty-monastrol derivatives and its cytotoxic effect against melanoma cell growth. | de Moraes, MM., et al. 2017. Bioorg Chem. 72: 148-155. PMID: 28460356
- Monastrol, a 3,4-dihydropyrimidin-2(1H)-thione, as structural scaffold for the development of modulators for GHB high-affinity binding sites and α1β2Δ GABAA receptors. | Damgaard, M., et al. 2017. Eur J Med Chem. 138: 300-312. PMID: 28683403
- Monastrol derivatives: in silico and in vitro cytotoxicity assessments. | Bidram, Z., et al. 2020. Res Pharm Sci. 15: 249-262. PMID: 33088325
Inhibitor of:
α-SNAP, 1700019N19Rik, 2610039C10Rik, 4930404A10Rik, 4930521A18Rik, 4930534B04Rik, 5830418K08Rik, 9430070O13Rik, A330021E22Rik, ANKRD56, ANKT, AUNIP, AW555464, C10orf93, C16orf63_0610037P05Rik, C17orf55, C18orf15, C1orf96, C20orf19, CapG, CASC5, CCDC52, CCDC65, Cdc14, Cdc16, CENP-C, CENP-F, CENP-O, CENP-R, CENP-T, CENP-V, CENPBD1, CENPQ, CENPVL2, CENPVL3, centlein, Centrobin, CEP135, CEP152, CKAP5, CSPP1, CTAGE1, CTAGE2, CUG2, D14Ertd500e, DNAH1, DNAH5, DNAH7, DNAH9, DNAHC14, DNAHC7A, DNAL1, Dtl, Dynlt1b, EG231836, Eg5, ELYS, ENSMUSG00000073257, Esp1, FAM44B, Gm1305, Gm1564, GOLGA6L1, HAUS3, HAUS4, HAUS5_Haus5, HAUS6, hCAP-G, hCAP-H, HEATR6, HEI-C, HORMAD1, HURP, INSC, karyopherin α5, KIAA0284, KIAA1009, KIF (Kinesin family), KIF6, Kinectin 1, Kinesin, kinesin light chain, KLC, Klp3, KNL2, LGN, LIS1, Mad 1, Mad 3, MAD2_Mad2, MAD2L1BP, MASTL, MDM1, MEIG1, MEIKIN, Mitotic Cells, MKLP-1, MPHOSPH8, Myo2p, neuronal kinesin heavy chain, NOSTRIN, NSL1, NUDE1, NuMA, OIP5, Pericentrin 2, POC5, PPAN, PRR19, Rab GAP1, Rab GAP1L, RHOBTB3, RINT-1, Rootletin, rotatin, SAP 114, SAS-6, scc-112, SCP-1, Sgo1, Sgo2, Ska2, Slac2-a, SPANX-N1, SPANX-N4, Speriolin, SYCE1, Sycp2l, TACC1, Tctex1L, Tektin 5, TEX12, TNP2, TTC28, TTDN1, ubiquitous kinesin heavy chain, WDR19, WDR51B, WDR6, WDR60, and ZW10.Activator of:
α3e Tubulin, APC4, APC7, Aurora A, BUB1, C14orf106, C19orf21, C1orf96, C21orf59_1110004E09Rik, CAMSAP1, CCDC53, Cdc11, CENP-E, CENP-M, CENP-N, CENP-O, CENP-T, CENP-V, CENPQ, CEP55, CEP63, CKAP2L, CSAP, DNAH6, DSN1, EG231836, EML1, FAM110A, GCP6, Gm1305, HAUS3, HAUS6, Hec1, KIAA1671, KIF2C, KIF4A, KIFC2, KLC3, MIS12, NEDD1, Ninein, Ran BP-10, RCC1, SFI1, Ska1, Sororin, Spc25, SPDL-1, TACC3, TTBK1, TTK_Esk, UIP1, and ZWINT.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Monastrol, 1 mg | sc-202710 | 1 mg | $120.00 | |||
Monastrol, 5 mg | sc-202710A | 5 mg | $233.00 |