Molecular structure of Griseofulvin, CAS Number: 126-07-8
Griseofulvin (CAS 126-07-8)
See product citations (4)
Alternate Names:
(2S,6′R)-7-chloro-2′,4,6-trimethoxy-6′-methyl-3H-spiro[1-benzofuran-2,1′-cyclohexan]-2′-ene-3,4′-dione
Application:
Griseofulvin is an antifungal and antiproliferative agent that affects microtubules
CAS Number:
126-07-8
Purity:
≥95%
Molecular Weight:
352.77
Molecular Formula:
C17H17CIO6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Griseofulvin, an antifungal agent, has been reported to inhibit proliferation of various types of cells. This compound has also been shown to strongly suppress the dynamic instability of individual microtubules via reduction of the rate and extent of the growing and shortening phases. The effects that griseofulvin has on microtubules can cause mitotic arrest and abnormalities, such as multipolar spindles, misaligned chromosomes, and fragmented nuclei.
Griseofulvin (CAS 126-07-8) References
- Influence of Griseofulvin treatment on semen quality in the dog. | von Heimendahl, A., et al. 2004. Anim Reprod Sci. 80: 175-81. PMID: 15036526
- Preparation and characterization of poly-epsilon-caprolactone nanoparticles containing griseofulvin. | Zili, Z., et al. 2005. Int J Pharm. 294: 261-7. PMID: 15814249
- Improving the high variable bioavailability of griseofulvin by SEDDS. | Arida, AI., et al. 2007. Chem Pharm Bull (Tokyo). 55: 1713-9. PMID: 18057745
- Griseofulvin, an oral antifungal agent, suppresses hepatitis C virus replication in vitro. | Jin, H., et al. 2008. Hepatol Res. 38: 909-18. PMID: 18624717
- Hepatic damage and oxidative stress induced by Griseofulvin in mice. | Martinez, Mdel C., et al. 2009. Cell Mol Biol (Noisy-le-grand). 55: 127-39. PMID: 19656461
- Griseofulvin stabilizes microtubule dynamics, activates p53 and inhibits the proliferation of MCF-7 cells synergistically with vinblastine. | Rathinasamy, K., et al. 2010. BMC Cancer. 10: 213. PMID: 20482847
- On the polymorphism of griseofulvin: identification of two additional polymorphs. | Mahieu, A., et al. 2013. J Pharm Sci. 102: 462-8. PMID: 23132509
- Synthesis and activities towards resistant cancer cells of sulfone and sulfoxide griseofulvin derivatives. | Liéby-Muller, F., et al. 2015. Bioorg Med Chem Lett. 25: 2078-81. PMID: 25872984
- [Severe cutaneous drug reactions to misused griseofulvin: 2 cases]. | Le Guern, A., et al. 2016. Ann Dermatol Venereol. 143: 219-22. PMID: 26831946
- Ethosomes for enhanced skin delivery of griseofulvin. | Marto, J., et al. 2016. Colloids Surf B Biointerfaces. 146: 616-23. PMID: 27429295
- Synthesis and formulation studies of griseofulvin analogues with improved solubility and metabolic stability. | Petersen, AB., et al. 2017. Eur J Med Chem. 130: 240-247. PMID: 28258034
- Chemoselective fluorination and chemoinformatic analysis of griseofulvin: Natural vs fluorinated fungal metabolites. | Paguigan, ND., et al. 2017. Bioorg Med Chem. 25: 5238-5246. PMID: 28802670
- Griseofulvin Derivatives: Synthesis, Molecular Docking and Biological Evaluation. | Kartsev, V., et al. 2019. Curr Top Med Chem. 19: 1145-1161. PMID: 31119999
- Antibacterial activity of griseofulvin analogues as an example of drug repurposing. | Geronikaki, A., et al. 2020. Int J Antimicrob Agents. 55: 105884. PMID: 31931149
Inhibitor of:
α Tubulin, α3C Tubulin, α3d Tubulin, α4a Tubulin, β-Tubulin, β1 Tubulin, β2B Tubulin, β2C Tubulin, β3 Tubulin, β4 Tubulin, β4Q Tubulin, β6 Tubulin, β8 Tubulin, δ-tubulin, γ Tubulin, γ2 Tubulin, 1700019N19Rik, 1810043G02Rik, 4732456N10Rik, 4930415F15Rik, 4930415O20Rik, 4930427A07Rik, 4930521A18Rik, 4933403G14Rik, 5830418K08Rik, 6330407J23Rik, 9230110C19Rik, 9330101J02Rik, 9530077C05Rik, 9830001H06Rik, A330021E22Rik, A730037C10Rik, AK129341, ALAS-E, ALAS-H, ARL6, ARMC2, ARMC4, Aspergillus, AW555464, B23, BART1, BBS10, BICD2, C10orf93, C12orf23, C12orf55, C16orf63_0610037P05Rik, C17orf98, C19orf71, C1orf96, C20orf19, C8orf37, C8orf45, C9orf116, CAMSAP1, CAMSAP3, CapG, CCDC136, CCDC137, CCDC61, CCDC62, CCDC74A, CENP-F, CENP-I, CENP-L, CENP-N, CENP-V, CENPQ, Centrobin, CEP135, CEP170, CKAP5, CLIP-115, CMG, COL28A1, CSAP, CSPP1, CUG2, CYP4Z1, Cytokeratin 6, Cytokeratin 75, D230039L06Rik, DDX31, DNAH17, DNAH2, DNAH7, DNAH9, DNAHC14, DNAHC7A, DNAHC7L, DNAL1, DNCLI1, Dynactin 5, DYNC2H1, Dynein LC, EAN57, EG546143, ELYS, EML6, ENSMUSG00000073257, Epiplakin (EPPK), FATP4, FLJ23152, FSIP1, FSIP2, GAGE12B, Gas2L3, GCP3, GCP4, GCP6, Gm1305, Gm1564, Gm1568, Gm1574, Gm166, GOLGA6A, GOLGA8R, GTL3, HAUS3, HAUS4, HAUS6, hCAP-G, HCCS, HEATR6, Hippi, HORMAD1, HURP, HYDIN, HYLS1, IFT20, IFT52, IFT81, karyopherin α7, karyopherin β2B, Katanin p60 A1, Katanin p60 AL2, Katanin p80 BL1, Keratin 83, KIAA0284, KIAA0841, KIAA0895L_4931428F04Rik, LAPSER1, LCA5, LLC1, Mad 4, MAP-1A, MAP-7, MAP1D, MAP7D3, MAPRE (microtubule associated protein RP/EB), MEIG1, MFAP1B, Microtubule Marker, MITD1, mKIAA1853, Mlp2, MZT1, NDEL1, NF-L, NF-M, Ninein, NO145, nudel, NuMA, Odf2, Odf2L, Odf3l2, Op18, PAC2, periphilin 1, POC5, prefoldin 4, Rec8, REEP1, RGPD3, Rrn3, Ruvbl2, SAS-4, SAS-6, SAS10, SCLIP, SCP-1, Separase, Septin 14, Sil, Ska2, SLAIN2, SPAG16, SPAG17, SPANX-C, SPANX-N1, SPANX-N4, Spastin, SPATA6, Speriolin, Sycp2l, Syncoilin, Syntabulin, Tβ-10, TACC1, TACC2, TBCB, TBCC, TBCCD1, TBCE, TC1, TCP-1 η, Tctex1D1, Tctex1D2, Tctex2, TDRD6, Tektin 4, Tektin 5, TEX12, TFIID, TNP2, TPPP, TPPP2, trichoplein, TSGA2, TTC27, TTC28, TTC30A, TTLL1, TTLL4, TTLL5, TTLL6, TTLL7, TTLL8, Tub, TUBAL3, TULP2, TULP4, URO-10, UROS, WDR19, WDR34, and WDR60.Activator of:
α1a Tubulin, α1b Tubulin, β5 Tubulin, β8 Tubulin, ε Tubulin, 2310002L13Rik, 9830001H06Rik, AK129341, ANKT, C14orf65, C14orf80, C17orf98, C9orf116, CENPQ, CEP135, CKAP2L, DNAH6, Dynactin 3, Dynlt1b, EG546143, EML4, Esp1, GCP6, HAGHL, HEM1, KIF25, Klp3, MAP-7, MDM1, MTUS1, NEDD1, pierce 1, PPOX, TBCA, TBCC, TTLL11, and UGT2B7.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Griseofulvin, 5 mg | sc-202171A | 5 mg | $83.00 | |||
Griseofulvin, 25 mg | sc-202171 | 25 mg | $216.00 | |||
Griseofulvin, 100 mg | sc-202171B | 100 mg | $586.00 |