Date published: 2025-10-21

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ZM-447439 (CAS 331771-20-1)

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Alternate Names:
N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide
Application:
ZM-447439 is a selective inhibitor of ARK-1, ARK-2, and ARK-3
CAS Number:
331771-20-1
Purity:
≥99%
Molecular Weight:
513.6
Molecular Formula:
C29H31N5O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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ZM-447439 is a selective inhibitor of aurora kinases ARK-1 (A) (IC50=1000 nM), ARK-2 (B) (IC50= 50 nM) and ARK-3 (C), that can induce growth arrest, inhibit histone H3 phosphorylation and effectively activate apoptosis. The compound specifically interacts at the ATP-binding site and at the adjacent cleft, found only in aurora kinases. In the presence of Z-M447439, chromosome alignment, segregation, and cytokinesis during mitosis are unsuccessful. Studies show that ZM-447439 can override the spindle assembly checkpoint and accelerate meiosis I in mouse oocytes.


ZM-447439 (CAS 331771-20-1) References

  1. Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores.  |  Ditchfield, C., et al. 2003. J Cell Biol. 161: 267-80. PMID: 12719470
  2. Effects of the aurora kinase inhibitors AZD1152-HQPA and ZM447439 on growth arrest and polyploidy in acute myeloid leukemia cell lines and primary blasts.  |  Walsby, E., et al. 2008. Haematologica. 93: 662-9. PMID: 18367484
  3. ZM 447439 inhibition of aurora kinase induces Hep2 cancer cell apoptosis in three-dimensional culture.  |  Long, ZJ., et al. 2008. Cell Cycle. 7: 1473-9. PMID: 18418083
  4. Aurora kinase inhibitor ZM447439 induces apoptosis via mitochondrial pathways.  |  Li, M., et al. 2010. Biochem Pharmacol. 79: 122-9. PMID: 19686703
  5. Aurora kinase B, epigenetic state of centromeric heterochromatin and chiasma resolution in oocytes.  |  Vogt, E., et al. 2009. Reprod Biomed Online. 19: 352-68. PMID: 19778480
  6. ZM447439, a novel promising aurora kinase inhibitor, provokes antiproliferative and proapoptotic effects alone and in combination with bio- and chemotherapeutic agents in gastroenteropancreatic neuroendocrine tumor cell lines.  |  Georgieva, I., et al. 2010. Neuroendocrinology. 91: 121-30. PMID: 19923785
  7. Antiproliferative effect of Aurora kinase targeting in mesothelioma.  |  Crispi, S., et al. 2010. Lung Cancer. 70: 271-9. PMID: 20371132
  8. The Aurora kinase inhibitor ZM447439 accelerates first meiosis in mouse oocytes by overriding the spindle assembly checkpoint.  |  Lane, SI., et al. 2010. Reproduction. 140: 521-30. PMID: 20660090
  9. A comparative study of the aneugenic and polyploidy-inducing effects of fisetin and two model Aurora kinase inhibitors.  |  Gollapudi, P., et al. 2014. Mutat Res Genet Toxicol Environ Mutagen. 767: 37-43. PMID: 24680981
  10. CyclinG1 Amplification Enhances Aurora Kinase Inhibitor-Induced Polyploid Resistance and Inhibition of Bcl-2 Pathway Reverses the Resistance.  |  Zhang, W., et al. 2017. Cell Physiol Biochem. 43: 94-107. PMID: 28848145
  11. The activity of Aurora kinase B is required for dengue virus release.  |  Pérez-Olais, JH., et al. 2019. Virus Res. 274: 197777. PMID: 31626875
  12. Cytogenetically-based biodosimetry after high doses of radiation.  |  Pujol-Canadell, M., et al. 2020. PLoS One. 15: e0228350. PMID: 32320391
  13. The Prognostic Model and Drug Sensitivity of LKB1-Mutant Lung Adenocarcinoma Based on Immune Landscape.  |  Wang, G., et al. 2022. Front Mol Biosci. 9: 756772. PMID: 35720127

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

ZM-447439, 1 mg

sc-200696
1 mg
$150.00

ZM-447439, 10 mg

sc-200696A
10 mg
$349.00