Nectin 3 Activators
Nectin 3 Activators represent a class of chemicals that influence the functional state of the protein Nectin 3 by modulating various cellular signaling pathways with which Nectin 3 is associated. These activators encompass a range of biochemical categories, including growth factors, enzyme activators, ionophores, and others that impact intracellular signaling cascades, which in turn affect the behavior and interactions of Nectin 3 in cellular processes, particularly those related to cell adhesion and migration.
For instance, chemicals like EGF and Forskolin activate specific pathways such as the ERBB receptor signaling and cAMP-mediated pathways, respectively, leading to downstream effects that can alter the functional dynamics of Nectin 3. Similarly, ionophores like A23187 and Ionomycin raise intracellular calcium levels, thereby initiating calcium-sensitive reactions that can potentiate the adhesive capabilities of Nectin 3. On the other hand, Bryostatin 1 and Phorbol 12-myristate 13-acetate act through the activation of Protein Kinase C, with implications for the regulation of cell junctions where Nectin 3 is a critical component.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA acts as a diacylglycerol analog, activating Protein Kinase C (PKC). PKC has various roles, including regulation of cell junction formation where nectins participate. Activation of PKC leads to cytoskeletal reorganization affecting nectin-3’s role in cell adhesion. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
This compound increases intracellular calcium levels, activating calcium-sensitive signaling pathways. Elevated calcium can modulate adhesion molecules’ behavior, including nectin-3, enhancing their cell surface expression and adhesion capability. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels, which in turn activates PKA. PKA phosphorylates various proteins, potentially affecting the intracellular domains of nectin-3, thus influencing its adhesion properties. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is another calcium ionophore which elevates intracellular calcium concentration, affecting calcium-dependent signaling pathways and possibly enhancing nectin-3-mediated cell-cell adhesion. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $116.00 $179.00 $265.00 $369.00 $629.00 $1150.00 | ||
It’s a cAMP analog that activates PKA. PKA activation can lead to changes in cell adhesion molecule interactions, including those involving nectin-3, promoting cell junction stability. | ||||||
Bryostatin 1 | 83314-01-6 | sc-201407 | 10 µg | $245.00 | 9 | |
Bryostatin 1 is a PKC activator which can lead to the modulation of cell adhesion processes. It potentially influences nectin-3 interactions at the adherens junctions. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
It is a SERCA pump inhibitor leading to increased cytosolic calcium levels and activation of calcium-mediated signaling, which can enhance the activation state of nectin-3. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
A beta-adrenergic agonist that raises cAMP levels, leading to PKA activation. PKA can subsequently modulate the cytoplasmic interactions of nectin-3, possibly promoting its adhesive functions. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can influence gene expression and has been shown to upregulate certain cell adhesion molecules. This effect could extend to nectin-3, enhancing its expression and function in cell-cell adhesion. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits GSK-3β, leading to altered intracellular signaling and potentially increasing the stability of cell adhesion complexes where nectin-3 is involved. | ||||||