Nectin 3 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $62.00 $112.00 $214.00 $342.00 | 74 | |
Gefitinib is an EGFR tyrosine kinase inhibitor that blocks EGF signaling. Since EGF signaling can enhance Nectin 3 function, its inhibition by Gefitinib can lead to reduced activity of Nectin 3 in cell adhesion processes. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A potent PKC inhibitor, Staurosporine, can diminish PKC-mediated pathways that are involved in cell adhesion and junction formation, thereby potentially decreasing the activation and function of Nectin 3 at these sites. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
BAPTA-AM is a cell-permeable calcium chelator that reduces intracellular calcium levels, thereby potentially disrupting calcium-dependent signaling pathways that can modulate Nectin 3 activation and function. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $92.00 $182.00 | 71 | |
H-89 is an inhibitor of PKA, and by suppressing this kinases activity, it can lead to decreased phosphorylation of substrates involved in cell adhesion, possibly affecting Nectin 3-mediated cell junction integrity. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
This compound is another PKC inhibitor that can prevent the activation of PKC-dependent pathways, which are known to influence the assembly and maintenance of cell-cell junctions where Nectin 3 functions. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 is a MEK inhibitor, and while not directly linked to Nectin 3, it may impact ERK signaling pathways that influence cell adhesion and migration, processes in which Nectin 3 is involved. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
An inhibitor of the PI3K/Akt pathway, LY294002, can impact various cellular processes including cell migration and adhesion. PI3K/Akt signaling has been implicated in the regulation of cell junctions and could affect Nectin 3 activity indirectly. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $88.00 $311.00 | 17 | |
Chelerythrine is a selective PKC inhibitor. By inhibiting PKC, it can reduce the phosphorylation and subsequent activation of proteins involved in the formation and maintenance of adherens junctions, including Nectin 3. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $27.00 $52.00 | 37 | |
2-APB is known to modulate calcium channels and related signaling. By affecting these pathways, 2-APB can alter the intracellular signaling that contributes to the regulation of Nectin 3s adhesion functions. | ||||||
Calphostin C | 121263-19-2 | sc-3545 sc-3545A | 100 µg 1 mg | $336.00 $1642.00 | 20 | |
Calphostin C is a specific inhibitor of PKC that binds to the regulatory domain of the enzyme in a light-dependent manner, decreasing its activity and thereby potentially reducing the functional activation of Nectin 3 involved in cell-cell adhesion. | ||||||