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Nectin 3 Antibody (H-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects Nectin 3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Nectin 3 antibody (H-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Nectin 3, also known as poliovirus receptor-related protein 3 (PRR3), plays a crucial role in cell adhesion and is a member of the immunoglobulin superfamily. Nectin 3 is primarily located in the cell membrane, where Nectin 3 facilitates homophilic interactions between adjacent cells, which is essential for maintaining tissue architecture and integrity. Nectin 3′s presence at cadherin-based adherens junctions allows for stable cell-cell contacts formation, vital for processes such as tissue development, immune response, and epithelial barrier maintenance. Nectin 3 interacts with the actin cytoskeleton through a C-terminal conserved motif, linking to F-actin-binding protein afadin, thereby influencing cellular signaling pathways and cytoskeletal dynamics. Three splicing variants—Nectin 3α, 3β, and 3γ—exhibit distinct functional properties, with Nectin 3α and 3β being particularly important for interactions with afadin and other cellular components. This multifaceted role underscores Nectin 3′s significance in both normal physiological processes and potential pathological conditions, making Nectin 3 (H-11) monoclonal antibody an invaluable tool for researchers studying cell adhesion mechanisms and related diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nectin 3 Antibody (H-11) | sc-271611 | 200 µg/ml | $316.00 | |||
Nectin 3 Antibody (H-11): m-IgG Fc BP-HRP Bundle | sc-529222 | 200 µg Ab; 10 µg BP | $354.00 | |||
Nectin 3 Antibody (H-11): m-IgGκ BP-HRP Bundle | sc-521997 | 200 µg Ab, 40 µg BP | $354.00 | |||
Nectin 3 Antibody (H-11): m-IgG1 BP-HRP Bundle | sc-543397 | 200 µg Ab; 20 µg BP | $354.00 | |||
Nectin 3 Antibody (H-11) AC | sc-271611 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Nectin 3 Antibody (H-11) HRP | sc-271611 HRP | 200 µg/ml | $316.00 | |||
Nectin 3 Antibody (H-11) FITC | sc-271611 FITC | 200 µg/ml | $330.00 | |||
Nectin 3 Antibody (H-11) PE | sc-271611 PE | 200 µg/ml | $343.00 | |||
Nectin 3 Antibody (H-11) Alexa Fluor® 488 | sc-271611 AF488 | 200 µg/ml | $357.00 | |||
Nectin 3 Antibody (H-11) Alexa Fluor® 546 | sc-271611 AF546 | 200 µg/ml | $357.00 | |||
Nectin 3 Antibody (H-11) Alexa Fluor® 594 | sc-271611 AF594 | 200 µg/ml | $357.00 | |||
Nectin 3 Antibody (H-11) Alexa Fluor® 647 | sc-271611 AF647 | 200 µg/ml | $357.00 | |||
Nectin 3 Antibody (H-11) Alexa Fluor® 680 | sc-271611 AF680 | 200 µg/ml | $357.00 | |||
Nectin 3 Antibody (H-11) Alexa Fluor® 790 | sc-271611 AF790 | 200 µg/ml | $357.00 |