NAT-3 Activators
N-acetyltransferase 3 (NAT-3) activators are compounds that indirectly influence the functional mechanisms of this membrane-bound enzyme involved in amino acid transport. Rather than directly binding to and activating NAT-3, these molecules exert their effects through modulation of various cellular signaling pathways that, in turn, can lead to alterations in NAT-3 activity. Among these compounds, calcium ionophore A23187 and forskolin are notable examples. A23187 facilitates the transport of calcium ions across cell membranes, potentially affecting NAT-3 by altering calcium-dependent signaling cascades. Forskolin, on the other hand, increases intracellular cAMP levels, leading to PKA activation, which could phosphorylate proteins that regulate the function or expression of NAT-3.
Other activators include PMA, which activates PKC, potentially influencing NAT-3 by modifying phosphorylation patterns that control transporter activity. Genistein, as a kinase inhibitor, can disrupt kinase-dependent signaling pathways, indirectly affecting NAT-3's regulatory mechanisms. Compounds like dibutyryl-cyclic AMP and N6-Benzoyladenosine-3',5'-cyclic monophosphate, both cAMP analogs, mimic endogenous cAMP and activate PKA, impacting NAT-3 activity by influencing cellular phosphorylation states. Additionally, polyamines like spermine, although their precise mechanisms are less defined, have the potential to modulate ion channels and transporters, thus indirectly affecting NAT-3 activity. It is important to note that the activation of NAT-3 by these compounds is not a result of direct protein-ligand interactions. Instead, these chemicals act on various upstream pathways and processes within the cell that influence the operational state of NAT-3. By interacting with signaling molecules, altering intracellular messenger levels, and affecting phosphorylation events, these activators collectively provide a means of modulating NAT-3 activity, expanding the functional landscape in which this transporter operates.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Calcium ionophore A23187 facilitates the influx of calcium ions into cells by forming complexes with the ions and transporting them across the cell membrane. Given the role of calcium as a secondary messenger in many signaling pathways, the elevation of intracellular calcium levels could indirectly enhance the activity of NAT-3 by modulating various signaling cascades that lead to the activation of transport proteins. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a known activator of protein kinase C (PKC), which is involved in a wide array of signal transduction pathways. Activation of PKC has been implicated in the regulation of various transporters and could potentially influence NAT-3 activity by phosphorylating proteins that modulate transporter function or membrane localization. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that also acts as a modulator for various cellular functions. By inhibiting certain kinases, genistein may alter signaling pathways that indirectly modulate the activity or expression of transporters such as NAT-3. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $116.00 $179.00 $265.00 $369.00 $629.00 $1150.00 | ||
Dibutyryl-cyclic AMP is a cell-permeable analog of cAMP that can diffuse into cells and mimic the action of endogenous cAMP, leading to activation of PKA. This compound can thereby alter various cellular processes, including potentially upregulating the function of membrane transporters like NAT-3. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $61.00 $196.00 $277.00 $901.00 | 1 | |
Spermine is a polyamine that has been shown to modulate ion channel and transporter activity. The exact mechanism by which spermine could activate NAT-3 is not well understood, but its interaction with cellular membranes and proteins might influence transporter function. | ||||||
Adenosine 3′,5′-cyclic Monophosphate, N6-Benzoyl-, Sodium Salt | 30275-80-0 | sc-300167 | 10 µmol | $324.00 | 1 | |
This compound is a cAMP analog that activates PKA. By activating PKA, it may influence the phosphorylation state of proteins associated with the regulation of transporter activity, indirectly affecting NAT-3. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
Sodium orthovanadate acts as a general inhibitor of tyrosine phosphatases. By inhibiting these phosphatases, it can influence the phosphorylation state of proteins within the cell, potentially affecting the activity of transport proteins like NAT-3. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, which increases intracellular levels of cAMP by preventing its degradation. Elevated cAMP levels can indirectly influence NAT-3 activity through PKA-mediated signaling pathways. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Nicotinamide is a form of vitamin B3 and has been shown to influence cellular metabolism and signaling. It may exert indirect effects on NAT-3 activity by modulating cellular energy states or signaling pathways that affect transporter function. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can modulate the activity of a wide array of proteins through its interaction with various signaling pathways. While its direct effect on NAT-3 is not clear, curcumin may influence transporter activity through its effects on cellular signaling and protein interactions. | ||||||