MS4A5 Activators
MS4A5 can engage multiple biochemical pathways to modulate the protein's activity. Phorbol 12-myristate 13-acetate (PMA), a potent activator of Protein Kinase C (PKC), initiates a phosphorylation cascade that can lead to the functional activation of MS4A5. Similarly, synthetic analogs of diacylglycerol such as 1,2-Dioctanoyl-sn-glycerol (DiC8) and natural lipid messengers like phosphatidic acid serve as PKC activators, which then target proteins like MS4A5 for phosphorylation. Notably, Bryostatin 1 and Oleoylethanolamide (OEA) also activate PKC, further contributing to the network of activators capable of modulating MS4A5 activity. On a related front, forskolin and Isoproterenol, through their interactions with adenylyl cyclase, increase intracellular cAMP levels. The resultant activation of Protein Kinase A (PKA) provides another avenue for the phosphorylation and consequent activation of MS4A5. Dibutyryl-cAMP (db-cAMP), a cAMP analog, similarly activates PKA, contributing to the phosphorylation-driven activation of MS4A5.
calcium ionophores like Ionomycin and A23187 raise intracellular calcium levels, triggering the activation of calcium-dependent kinases that may phosphorylate MS4A5. The increase in intracellular calcium can act as a second messenger in multiple signaling pathways, indirectly facilitating the activation of MS4A5 through phosphorylation by these kinases. Additionally, Anisomycin, while primarily known as a protein synthesis inhibitor, can activate stress-activated protein kinases (SAPKs) that may target MS4A5 for phosphorylation. Okadaic acid, by inhibiting protein phosphatases 1 and 2A, impedes the dephosphorylation process, potentially maintaining MS4A5 in an active state. Collectively, these chemical activators employ distinct yet converging pathways to modulate the activity state of MS4A5 through phosphorylation mechanisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates Protein Kinase C (PKC), which is a family of protein kinase enzymes. MS4A5, as a transmembrane protein, may be phosphorylated by PKC, leading to its functional activation as part of intracellular signaling cascades. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, increasing levels of cAMP. Elevated cAMP activates PKA (Protein Kinase A), which can then phosphorylate various proteins, including transmembrane proteins like MS4A5, potentially leading to their activation. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $94.00 $259.00 | 2 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Calcium acts as a second messenger in various signaling pathways and can activate calcium-dependent protein kinases, which may phosphorylate and activate MS4A5. | ||||||
1,2-Dioctanoyl-sn-glycerol | 60514-48-9 | sc-202397 sc-202397A | 10 mg 50 mg | $46.00 $249.00 | 2 | |
DiC8 is a synthetic analog of diacylglycerol (DAG), acting as a PKC activator. By activating PKC, DiC8 might lead to the phosphorylation and activation of proteins like MS4A5. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that activates adenylyl cyclase through G protein-coupled receptor signaling, increasing cAMP levels, which activates PKA. Activated PKA may phosphorylate MS4A5, leading to its functional activation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is another calcium ionophore that increases intracellular calcium levels. This increase can activate calcium-sensitive proteins, which could phosphorylate and activate MS4A5. | ||||||
Bryostatin 1 | 83314-01-6 | sc-201407 | 10 µg | $240.00 | 9 | |
Bryostatin 1 is a PKC activator, potentially resulting in the phosphorylation of proteins including MS4A5, which can activate its signaling function. | ||||||
Oleylethanolamide | 111-58-0 | sc-201400 sc-201400A | 10 mg 50 mg | $88.00 $190.00 | 1 | |
OEA is a naturally occurring ethanolamide lipid, which can activate PKC. Through PKC activation, OEA may promote the phosphorylation and activation of MS4A5. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that can also activate stress-activated protein kinases (SAPKs). These kinases might phosphorylate MS4A5, thereby activating its function. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is an inhibitor of protein phosphatases 1 and 2A, which prevents dephosphorylation of proteins, potentially keeping MS4A5 in an activated phosphorylated state. | ||||||