MS4A5 Inhibitors
MS4A5 Inhibitors encompass a diverse range of compounds that exert their effects through various signaling pathways that MS4A5 is likely to be involved in. Wortmannin and LY294002, as PI3K inhibitors, would lead to a decrease in the activation of the PI3K/A KT pathway, potentially resulting in a decrease in MS4A5 activity if it is downstream of this signaling cascade. Other inhibitors, targeting different kinases and signaling pathways, may also reduce MS4A5 activity if MS4A5 is a part of or regulated by those pathways.
For instance, Rapamycin's inhibition of mTOR can affect protein synthesis and cell survival pathways, potentially impacting MS4A5 if it's downstream of mTOR signaling. Similarly, MEK inhibitors like U0126 and PD98059, by blocking the activation of the MAPK/ERK pathway, could reduce MS4A5 activity if it's regulated by ERK signaling.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent and irreversible inhibitor of phosphoinositide 3-kinases (PI3K), which are known to be involved in various cellular processes including cell growth and survival. By inhibiting PI3K, Wortmannin can prevent the activation of AKT, a kinase that may be upstream of MS4A5. As PI3K/AKT signaling is crucial for some proteins' stability and function, the inhibition of this pathway can lead to a decrease in MS4A5 activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a chemical inhibitor of PI3K, similar to Wortmannin, and it can also lead to a reduction in AKT phosphorylation. Given that MS4A5 might be regulated by the PI3K/AKT pathway, the inhibition of PI3K by LY294002 can result in a reduction of MS4A5 functional activity due to decreased downstream signaling. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin specifically binds to mTORC1 and inhibits its function. Since mTORC1 influences cellular growth and survival by affecting protein synthesis and other processes, its inhibition can lead to a reduction in the activity of proteins that are regulated by mTOR signaling, potentially including MS4A5. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 selectively inhibits MEK1/2, which are upstream of ERK1/2 in the MAPK pathway. By inhibiting MEK, U0126 can decrease ERK-mediated phosphorylation events. If MS4A5 is activated by the MEK/ERK pathway, then MEK inhibition would reduce MS4A5 activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAPK and by inhibiting p38 MAPK, it can decrease the activity of proteins regulated by p38 MAPK signaling. MS4A5, if it is influenced by p38 MAPK, would have its functional activity inhibited as a result. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits the JNK pathway, which can lead to a reduction in the functional activity of proteins that are regulated by JNK signaling. Inhibition by SP600125 would lead to decreased MS4A5 activity if MS4A5 is a downstream target of the JNK pathway. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib is an inhibitor of Src family kinases and by suppressing these kinases, it can affect various downstream signaling pathways, including those involving PI3K/AKT. If MS4A5 operates downstream of Src family kinases, Dasatinib would inhibit MS4A5 activity. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is an inhibitor of Src family kinases, which are involved in multiple signaling pathways. If MS4A5 is regulated by Src kinases, PP2 would reduce MS4A5 activity due to inhibited Src signaling. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor that impedes the activation of the MEK/ERK pathway. Inhibition of MEK by PD98059 would result in a reduction of MS4A5 activity if MS4A5's function is dependent on the MEK/ERK pathway. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
BAY 11-7082 is an inhibitor of NF-κB activation, which plays a role in immune response and cell survival. Inhibiting NF-κB can decrease the functional activity of proteins regulated by this pathway, possibly including MS4A5. | ||||||