Date published: 2025-11-21

1-800-457-3801

SCBT Portrait Logo
Seach Input

PP 2 (CAS 172889-27-9)

5.0(1)
Write a reviewAsk a question

See product citations (30)

Alternate Names:
AGL 1879; 4-Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine; PP2
Application:
PP 2 is an effective and selective inhibitor of Src family kinases
CAS Number:
172889-27-9
Purity:
≥95%
Molecular Weight:
301.77
Molecular Formula:
C15H16ClN5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

PP 2 is an effective and selective inhibitor of c-Src family kinases. The inhibitor may act to inhibit Lck, FynT, phosphorylation of focal adhesion kinase (FAK) and potently inhibits Hck, Lck (p56) and Fyn (p59). Additionally, PP 2 was reported to inhibit tyrosone kinase-dependent TcR-induced T cell proliferation. PP 2 studies indicate that this agent has demonstrated the ability to activate ERK 1, ERK 2 and p38. Research suggests that PP 2 may be useful to help identify c-Src family member substrates. MCF-7 cell research shows that PP 2 down regulates the expression of both enoyl-CoA hydratase short chain 1 and peroxiredoxin 3 (PRDX3), and induces apoptosis. PP 2 is an inhibitor of casein kinase I delta and RICK.


PP 2 (CAS 172889-27-9) References

  1. Bombesin and platelet-derived growth factor induce association of endogenous focal adhesion kinase with Src in intact Swiss 3T3 cells.  |  Salazar, EP. and Rozengurt, E. 1999. J Biol Chem. 274: 28371-8. PMID: 10497197
  2. A role for Src kinase in spontaneous epileptiform activity in the CA3 region of the hippocampus.  |  Sanna, PP., et al. 2000. Proc Natl Acad Sci U S A. 97: 8653-7. PMID: 10890901
  3. The specificities of protein kinase inhibitors: an update.  |  Bain, J., et al. 2003. Biochem J. 371: 199-204. PMID: 12534346
  4. An unbiased cell morphology-based screen for new, biologically active small molecules.  |  Tanaka, M., et al. 2005. PLoS Biol. 3: e128. PMID: 15799708
  5. PP2 regulates human trophoblast cells differentiation by activating p38 and ERK1/2 and inhibiting FAK activation.  |  Daoud, G., et al. 2008. Placenta. 29: 862-70. PMID: 18783823
  6. The role of enoyl-CoA hydratase short chain 1 and peroxiredoxin 3 in PP2-induced apoptosis in human breast cancer MCF-7 cells.  |  Liu, X., et al. 2010. FEBS Lett. 584: 3185-92. PMID: 20541551
  7. X-ray crystal structure of bone marrow kinase in the x chromosome: a Tec family kinase.  |  Muckelbauer, J., et al. 2011. Chem Biol Drug Des. 78: 739-48. PMID: 21883956
  8. Effects of atrazine on estrogen receptor α- and G protein-coupled receptor 30-mediated signaling and proliferation in cancer cells and cancer-associated fibroblasts.  |  Albanito, L., et al. 2015. Environ Health Perspect. 123: 493-9. PMID: 25616260
  9. TLR9 stability and signaling are regulated by phosphorylation and cell stress.  |  Hasan, M., et al. 2016. J Leukoc Biol. 100: 525-33. PMID: 26957214
  10. Negative pressure induces p120-catenin-dependent adherens junction disassembly in keratinocytes during wound healing.  |  Huang, CH., et al. 2016. Biochim Biophys Acta. 1863: 2212-20. PMID: 27220534
  11. Tyrosine kinase, aurora kinase and leucine aminopeptidase as attractive drug targets in anticancer therapy - characterisation of their inhibitors.  |  Ziemska, J. and Solecka, J. 2016. Rocz Panstw Zakl Hig. 67: 329-342. PMID: 27922739
  12. Hexachlorobenzene alters cell cycle by regulating p27-cyclin E-CDK2 and c-Src-p27 protein complexes.  |  Ventura, C., et al. 2017. Toxicol Lett. 270: 72-79. PMID: 28215542
  13. Targeting RIPK3 oligomerization blocks necroptosis without inducing apoptosis.  |  Li, W., et al. 2020. FEBS Lett. 594: 2294-2302. PMID: 32412649
  14. Progesterone and its metabolite allopregnanolone promote invasion of human glioblastoma cells through metalloproteinase‑9 and cSrc kinase.  |  Bello-Alvarez, C., et al. 2023. Oncol Lett. 25: 223. PMID: 37153033
  15. Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation.  |  Hanke, JH., et al. 1996. J Biol Chem. 271: 695-701. PMID: 8557675

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

PP 2, 1 mg

sc-202769
1 mg
$92.00

PP 2, 5 mg

sc-202769A
5 mg
$223.00