MASP-2 Activators
MASP-2 plays a crucial role in the complement system, specifically in the lectin pathway, where it contributes to the recognition of pathogens and triggers the complement cascade. Chemicals such as E-64 and Epoxomicin can enhance the activation of MASP-2, as they lead to the accumulation of undegraded proteins, which can trigger the activation of the complement system. Lipopolysaccharide (LPS) and Zymosan can directly activate the lectin pathway of the complement system, thereby enhancing the functional activity of MASP-2.
In addition, A23187 and Ionomycin can increase intracellular calcium levels, potentially leading to the activation of the complement system and thus enhancing the functional activity of MASP-2. Phorbol 12-myristate 13-acetate (PMA) is a potent activator of protein kinase C (PKC), and its activation can lead to the release of cytokines that can activate the complement system, thereby enhancing the functional activity of MASP-2. N-Formylmethionine-leucyl-phenylalanine (fMLP) can activate neutrophils, causing the release of components that can stimulate the complement system, hence enhancing MASP-2 activity. Polyinosinic-polycytidylic acid (Poly I:C), Imiquimod, and Pam3CSK4, all act as stimulants to the immune system, which includes activation of the complement system and consequently enhancing the functional activity of MASP-2. Nigericin, a potassium ionophore, can disrupt cellular ion balance, which could potentially lead to the activation of the complement system, thereby enhancing the functional activity of MASP-2.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
E-64 | 66701-25-5 | sc-201276 sc-201276A sc-201276B | 5 mg 25 mg 250 mg | $281.00 $947.00 $1574.00 | 14 | |
E-64 inhibits cysteine proteases, leading to the accumulation of proteins that are typically degraded by these enzymes. The buildup of these proteins can result in complement system activation, a process in which MASP-2 plays a key role, thereby enhancing its functional activity. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $137.00 $219.00 $449.00 $506.00 | 19 | |
Epoxomicin is a proteasome inhibitor, which can lead to the accumulation of undegraded proteins. This accumulation can trigger complement system activation, which would involve and enhance the function of MASP-2. | ||||||
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $98.00 $171.00 $425.00 $1560.00 | 12 | |
LPS, a major component of the outer membrane of Gram-negative bacteria, can trigger the lectin pathway of the complement system, in which MASP-2 plays a crucial role, thereby leading to increased functional activity of MASP-2. | ||||||
Zymosan A from Saccharomyces cerevisiae | 58856-93-2 | sc-258367 sc-258367A | 250 mg 1 g | $90.00 $222.00 | 2 | |
Zymosan, a glucan with repeating glucose units, can activate the lectin pathway of the complement system, enhancing the functional activity of MASP-2, which is a key component of this pathway. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that can increase intracellular calcium levels. This can lead to the activation of the complement system, enhancing the functional activity of MASP-2. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). Activation of PKC can lead to the release of cytokines that can activate the complement system, thereby enhancing the functional activity of MASP-2. | ||||||
N-Formyl-L-methionine | 4289-98-9 | sc-215458 sc-215458A | 10 mg 250 mg | $25.00 $42.00 | ||
fMLP is a chemotactic peptide that can activate neutrophils, causing degranulation and the release of components that can stimulate the complement system, hence enhancing MASP-2 activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that can increase intracellular calcium levels. This can lead to the activation of the complement system, enhancing the functional activity of MASP-2. | ||||||
Polyinosinic acid - polycytidylic acid sodium salt, double-stranded | 42424-50-0 | sc-204854 sc-204854A | 10 mg 100 mg | $139.00 $663.00 | 2 | |
Poly I:C is a synthetic analog of double-stranded RNA that can trigger immune responses, including the activation of the complement system, thereby enhancing the functional activity of MASP-2. | ||||||
Imiquimod | 99011-02-6 | sc-200385 sc-200385A | 100 mg 500 mg | $67.00 $284.00 | 6 | |
Imiquimod is a toll-like receptor 7 agonist that can stimulate the innate immune response, including complement system activation, thereby enhancing the functional activity of MASP-2. | ||||||