Molecular structure of Imiquimod, CAS Number: 99011-02-6
Imiquimod (CAS 99011-02-6)
See product citations (6)
Alternate Names:
1-(2-Methylpropyl)-1H-imidazole[4,5-c]quinoline-4-amine
Application:
Imiquimod is a TLR7 activator and angiogenesis inhibitor
CAS Number:
99011-02-6
Purity:
≥98%
Molecular Weight:
240.30
Molecular Formula:
C14H16N4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Imiquimod is a chemical compound that has attention in immunological research. It is often used in studies to understand the induction of cytokines and the activation of immune cells. In the context of research applications, Imiquimod facilitates the investigation of innate immunity and the mechanisms through which the body responds to the presence of various antigens. The compound′s ability to enhance the production of interferon and other cytokines makes it useful for scientists examining the pathways that lead to an immune response. Additionally, Imiquimod is employed to better understand the molecular basis of immune cell activation and the subsequent effects on cells and tissues.
Imiquimod (CAS 99011-02-6) References
- Plasmacytoid dendritic cells produce cytokines and mature in response to the TLR7 agonists, imiquimod and resiquimod. | Gibson, SJ., et al. 2002. Cell Immunol. 218: 74-86. PMID: 12470615
- Tumor-selective induction of apoptosis and the small-molecule immune response modifier imiquimod. | Schön, M., et al. 2003. J Natl Cancer Inst. 95: 1138-49. PMID: 12902443
- Inhibition of murine tumor growth by an interferon-inducing imidazoquinolinamine. | Sidky, YA., et al. 1992. Cancer Res. 52: 3528-33. PMID: 1377595
- Taurine potentiates the antiaggregatory action of aspirin and indomethacin. | Franconi, F., et al. 1992. Adv Exp Med Biol. 315: 181-6. PMID: 1509937
- Imiquimod is a strong inhibitor of tumor cell-induced angiogenesis. | Majewski, S., et al. 2005. Int J Dermatol. 44: 14-9. PMID: 15663652
- Imiquimod as an antiangiogenic agent. | Li, VW., et al. 2005. J Drugs Dermatol. 4: 708-17. PMID: 16302556
- Common carp have two subclasses of bonyfish specific antibody IgZ showing differential expression in response to infection. | Ryo, S., et al. 2010. Dev Comp Immunol. 34: 1183-90. PMID: 20600275
- SIV infection induces accumulation of plasmacytoid dendritic cells in the gut mucosa. | Reeves, RK., et al. 2012. J Infect Dis. 206: 1462-8. PMID: 22711907
- Toll-like receptor (TLR) 3 as a surrogate sensor of retroviral infection in human cells. | Miyauchi, K., et al. 2012. Biochem Biophys Res Commun. 424: 519-23. PMID: 22771581
- Effects of repeated electroejaculations on kinematic sperm subpopulations and quality markers of Mexican creole goats. | Vázquez, AJ., et al. 2015. Anim Reprod Sci. 154: 29-38. PMID: 25600145
- GILZ regulates Th17 responses and restrains IL-17-mediated skin inflammation. | Jones, SA., et al. 2015. J Autoimmun. 61: 73-80. PMID: 26077873
- The toll-like receptor ligands Hiltonol® (polyICLC) and imiquimod effectively activate antigen-specific immune responses in Tasmanian devils (Sarcophilus harrisii). | Patchett, AL., et al. 2017. Dev Comp Immunol. 76: 352-360. PMID: 28689773
- Helicase-Driven Activation of NFκB-COX2 Pathway Mediates the Immunosuppressive Component of dsRNA-Driven Inflammation in the Human Tumor Microenvironment. | Theodoraki, MN., et al. 2018. Cancer Res. 78: 4292-4302. PMID: 29853604
- Electrospun Poly(ε-caprolactone) Nanofibrous Mesh for Imiquimod Delivery in Melanoma Therapy. | Lin, WC., et al. 2018. Polymers (Basel). 10: PMID: 30966266
Inhibitor of:
Angiogenesis, BAGE, CD1D, cryptdin 17, Cytokeratin 6B, Cytokeratin 6C, FLJ37396, GILT, HPV 16-E5, HPV 16-L1, HPV16 L1, HSV-1 ICP0, HSV-2, HSV-2 gB, IFI-202, IL-13Rα2, IL-17, KHNYN, KRTAP2-3, KSHV ORF 45, LA-PF4, LCE1A, LCE1D, LCE1F, Lce1h, Lce1j, LCE2C, LCE2D, LCE3C, LCE3D, LCE4A, MALL, ORMDL3, Plasmacytoid DC Marker, Rae-1ε, RP105, RSRC2, Siglec-H, Small Proline-Rich Protein (SPRR), SPRR1A, suprabasin, TL, and TLR7.Activator of:
α-defensin 6, β-defensin 111, β-defensin 131, β-defensin 14, β-defensin 3, 2010002M12Rik, AIM2, Azi2, B lymphocytes, B7-1, B7-H6, B7h, Baff, BCAP, BPIL3, C3b, C5β, caspase-3, CD1, CD14, CD16-2, CD16-A, CD1A, CD209b, CD209e, CD21L, CD225, CD23, CD8α, CL-P1, CLEC-12B, CLEC-4D, CLEC-4F, CLEC-5A, CLEC-9A, CMTM6, Coronavirus surface antigen, Cryopyrin, CS1, CT47A12, CTLA-4, CXCR-3, Cytokeratin 16, DC Marker, DC-SIGN, DCIR, DDX60L, DEC-205, Dppa1, EG432555, ERVMER34-1, FAM29A, FcRH5, Fcrl5, Follicular DC Marker, Fragilis, Francisella tularensis LPS, GBP1, GBP4, GBP5, GBP7, GBP8, Gight chain, Gram Negative Endotoxin Marker, granzyme C, GSDMDC1, H2-Ab, H2-Kk, H2-Kk,p,q,r,s, H2-M1, H2-M10.2, H2-M2, H2-Q2, H60a, Hep C cAg, HHV-8 K14, HLA-A, HLA-D, HLA-HB1, HNP-3, hornerin, HPV16 E2, HPV16 L2, HPV18 E2, HSV-1 gG, HSV-2 gG, ICSBP, IFI-16, IFI-203, IFI-205, IFI-35, IFIT1, IFIT1L, IFIT2, IFIT3, IFITM7, IFN-α1, IFN-α10, IFN-α11, IFN-α13, IFN-α14, IFN-α16, IFN-α2, IFN-α5, IFN-α6, IFN-α8, IFN-αB, IFN-β, IFN-γ, IFN-γRα, IFN-ω, IFRG15, Ig κ, IgA2, IgAight chain, IgG κ light chain, IgG λ light chain, IgG Fab fragment, IgG2a, IgG2c, IL-1α, IL-1β, IL-11Rα1, IL-12, IL-12A p35, IL-12B p40, IL-12B p70, IL-17REL, IL-18R, IL-1F6, IL-1RI, IL-23, IL-28, IL-28R, IL-3Rβ2, IL-TIFb, IL1F6, ILT-6, ILT-7, IRF-2BP2, IRF-3, IRF-5, IRG1, ISG12a, ISG12b2, ISG15, ISG43, KCP3, KIR3DS1, KLH-A, Klra22, KLRH1, KLRI1, LAIR-2, Lce1i, Lce1k, LGP2, Limitin, LIR-6, LST1, Ly49F, LYSMD4, Macrophagee Marker, MASP-2, MAVS, MB21D2, MD-2, MDA5, MDC, MDL-1, MHC, MHC class I, MHC class II, MHC class IIβ, MIP-1β, MIP-1γ, MIP-5, MLZE, Mndal, MRC1L1, Mx1, Mx2, Mx3, MxB, MYADML2, MyD88, NAIP1, NAIP2, NAIP5, NALP1, NALP13, NALP14, NALP1A, NALP1B, NALP2, NALP4B, NALP6, NALP9, NF kappa B, NK 2B4, NKLAM, NKp46, NOD3, OAS1, Oas1b, Oas1c, Oas1d, Oas1g, Oas1h, OASL, OASL1, Optineurin, OTTMUSG00000007655, OTTMUSG00000011262, OTTMUSG00000011269, OTTMUSG00000011275, OTTMUSG00000016644, Perforin 1, PGRP-Iα, PGRP-Iβ, PKR, Plasmacytoid DC Marker, Properdin, Rabies Virus, RAET1G, Rheumatoid Factor, RICK, RIG-I, RIP3, RNase 6, RNase 7, RT1-A, RT1-Ac, RT1-Bα, RT1-Bβ, Rubella Virus capsid protein, S-100A15, Salmonella O, SAMD9, SARM, Sectm1a, Siglec-14, SIRP-β1b, Slfn, Slfn4, Spi-B, SPPL2b, TAP, TBK1, TGTP, TICAM-1, TICAM-2, TIM-4, TIRAP, TLR1, TLR10, TLR12, TLR13, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TMEM143, TRIM34, TRIM43A, TRIM49, TRIM52, TRIM60, TSLP, ULBP5, UNC93B1, VpreB, WC1, and ZBP1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Imiquimod, 100 mg | sc-200385 | 100 mg | $66.00 | |||
Imiquimod, 500 mg | sc-200385A | 500 mg | $278.00 |