Date published: 2026-2-2

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Zymosan A from Saccharomyces cerevisiae (CAS 58856-93-2)

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Application:
Zymosan A from Saccharomyces cerevisiae is prepared from yeast cell wall and consists of protein-carbohydrate complexes
CAS Number:
58856-93-2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Zymosan A from Saccharomyces cerevisiae is prepared from yeast cell wall and consists of protein-carbohydrate complexes. It is used to induce experimental sterile inflammation. In macrophages, zymosan-induced responses include the induction of proinflammatory cytokines, arachidonate mobilization, protein phosphorylation, and inositol phosphate formation. Zymosan A from Saccharomyces cerevisiae also raises cyclin D2 levels suggesting a role for the latter in macrophage activation besides proliferation. It potentiates acute liver damage after galactosamine is introduced suggesting that certain types of nonparenchymal cells other than Kupffer cells are involved in Zymosan A from Saccharomyces cerevisiae action.


Zymosan A from Saccharomyces cerevisiae (CAS 58856-93-2) References

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  2. Carbohydrate-carbohydrate interaction: zymosan and beta-glucan from Saccharomyces cerevisiae bind mannosylated glycoconjugates.  |  Mikhalchik, EV., et al. 2000. Biochemistry (Mosc). 65: 494-501. PMID: 10810189
  3. Prostaglandin I2 plays a key role in zymosan-induced mouse pleurisy.  |  Yuhki, K., et al. 2008. J Pharmacol Exp Ther. 325: 601-9. PMID: 18256172
  4. Laminarin, a soluble beta-glucan, inhibits macrophage phagocytosis of zymosan but has no effect on lipopolysaccharide mediated augmentation of phagocytosis.  |  Fuentes, AL., et al. 2011. Int Immunopharmacol. 11: 1939-45. PMID: 21856445
  5. Zymosan induces NADPH oxidase activation in human neutrophils by inducing the phosphorylation of p47phox and the activation of Rac2: involvement of protein tyrosine kinases, PI3Kinase, PKC, ERK1/2 and p38MAPkinase.  |  Makni-Maalej, K., et al. 2013. Biochem Pharmacol. 85: 92-100. PMID: 23085266
  6. Orally delivered β-glucans aggravate dextran sulfate sodium (DSS)-induced intestinal inflammation.  |  Heinsbroek, SE., et al. 2015. Nutr Res. 35: 1106-12. PMID: 26500083
  7. Prostaglandins mediate zymosan-induced sickness behavior in mice.  |  Lima, JBM., et al. 2017. J Physiol Sci. 67: 673-679. PMID: 27699583
  8. Heme oxygenase-1-Dependent anti-inflammatory effects of atorvastatin in zymosan-injected subcutaneous air pouch in mice.  |  El-Achkar, GA., et al. 2019. PLoS One. 14: e0216405. PMID: 31071151
  9. The cooperative induction of macrophage activation by fucoidan derived from Cladosiphon okamuranus and β-glucan derived from Saccharomyces cerevisiae.  |  Miyazaki, Y., et al. 2019. Biochem Biophys Res Commun. 516: 245-250. PMID: 31221482
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  12. Non-invasive and accurate readout of superoxide anion in biological systems by near-infrared light.  |  Teranishi, K. 2021. Anal Chim Acta. 1179: 338827. PMID: 34535266
  13. Phagocytosis of antigens by Langerhans cells in vitro.  |  Reis e Sousa, C., et al. 1993. J Exp Med. 178: 509-19. PMID: 8393477
  14. Effects of hyperbaric oxygen exposure on a zymosan-induced shock model.  |  Luongo, C., et al. 1998. Crit Care Med. 26: 1972-6. PMID: 9875906

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Zymosan A from Saccharomyces cerevisiae, 250 mg

sc-258367
250 mg
$90.00

Zymosan A from Saccharomyces cerevisiae, 1 g

sc-258367A
1 g
$222.00