Polyinosinic acid - polycytidylic acid sodium salt, double stranded: sc-204854. Western blot analysis of CENP-B expression in untreated (A), Lysophosphatidic acid treated (B), Isoproterenol Hydrochloride treated (C) and Polyinosinic acid - polycytidylic acid sodium salt, double stranded treated (D) HEK293T whole cell lysates. β-Actin (C4): sc-47778 used as loading control. Detection reagent used: m-IgG1 BP-HRP: sc-525408. Antibody tested: CENP-B (F-4): sc-376283
Polyinosinic acid - polycytidylic acid sodium salt, double-stranded (CAS 42424-50-0)
See product citations (2)
Alternate Names:
Poly (I:C), Poly(I) • Poly(C)
Application:
Polyinosinic acid - polycytidylic acid sodium salt, double-stranded is a TLR3 (Toll-like receptor 3) agonist
CAS Number:
42424-50-0
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Polyinosinic acid - polycytidylic acid sodium salt, often referred to as poly(I:C) sodium salt, is a synthetic analog of double-stranded RNA (dsRNA) that is widely used in research to mimic viral infection. This compound is recognized by pattern recognition receptors such as Toll-like receptor 3 (TLR3) and retinoic acid-inducible gene I (RIG-I), which play critical roles in the innate immune response. In research applications, this compound is employed to study the cellular and molecular mechanisms underlying the immune response to viral infections, including the production of type I interferons and the activation of various signaling pathways. It is also used to investigate the impact of dsRNA recognition on the induction of apoptosis, inflammatory responses, and the activation of adaptive immune responses.
Polyinosinic acid - polycytidylic acid sodium salt, double-stranded (CAS 42424-50-0) References
- Toll-like receptor 3 agonist poly(I:C)-induced antiviral response in human corneal epithelial cells. | Kumar, A., et al. 2006. Immunology. 117: 11-21. PMID: 16423036
- TLR3: interferon induction by double-stranded RNA including poly(I:C). | Matsumoto, M. and Seya, T. 2008. Adv Drug Deliv Rev. 60: 805-12. PMID: 18262679
- Long-term activation of TLR3 by poly(I:C) induces inflammation and impairs lung function in mice. | Stowell, NC., et al. 2009. Respir Res. 10: 43. PMID: 19486528
- To poly(I:C) or not to poly(I:C): advancing preclinical schizophrenia research through the use of prenatal immune activation models. | Meyer, U. and Feldon, J. 2012. Neuropharmacology. 62: 1308-21. PMID: 21238465
- Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation. | Watanabe, A., et al. 2011. J Biol Chem. 286: 10702-11. PMID: 21266579
- TLR3 activation efficiency by high or low molecular mass poly I:C. | Zhou, Y., et al. 2013. Innate Immun. 19: 184-92. PMID: 23035017
- Poly(I:C) as cancer vaccine adjuvant: knocking on the door of medical breakthroughs. | Ammi, R., et al. 2015. Pharmacol Ther. 146: 120-31. PMID: 25281915
- TANK-binding kinase-1 broadly affects oyster immune response to bacteria and viruses. | Tang, X., et al. 2016. Fish Shellfish Immunol. 56: 330-335. PMID: 27422757
- Toll-like receptor 3-induced immune response by poly(d,l-lactide-co-glycolide) nanoparticles for dendritic cell-based cancer immunotherapy. | Han, HD., et al. 2016. Int J Nanomedicine. 11: 5729-5742. PMID: 27843314
- Exploiting poly(I:C) to induce cancer cell apoptosis. | Bianchi, F., et al. 2017. Cancer Biol Ther. 18: 747-756. PMID: 28881163
- Immunotherapeutic effects of intratumoral nanoplexed poly I:C. | Aznar, MA., et al. 2019. J Immunother Cancer. 7: 116. PMID: 31046839
- Mouse primary microglia respond differently to LPS and poly(I:C) in vitro. | He, Y., et al. 2021. Sci Rep. 11: 10447. PMID: 34001933
Inhibitor of:
Inhibin β-C, Olfr48, Olfr480, RNase 2, RP105, SP-100, Stabilin-1, and TLR3.Activator of:
α-defensin 6, β-defensin 111, β-defensin 131, β-defensin 46, ADAR3, Azi2, BST-2, C1orf43, C1rb, C5β, C8α, CCL16, CD14, CD160, CD1A, CD209c, CD209d, CD225, Chemokine Receptor D6, CKR-5, CL-P1, CLEC-1, CLEC-5A, CLEC-9A, CMTM6, CRAMP, CRS1C-2, DC Marker, DC-SIGNR, DDX60, DDX60L, Diphtheria Toxoid, Dppa1, Ear1, EG240921, EG432555, ERI-1, FCAMR, FHR-3, G3BP1, GBP1, GBP5, granzyme C, GRSF-1, H2-M1, H2-M2, H2-Q2, H60c, HCC-4, HisRS, HLA-DR, HNP-3, ICSBP, IDO, IFI-16, IFI-203, IFI-205, IFI-35, IFIT3, IFITM6, IFITM7, IFIX, IFN-α1, IFN-α11, IFN-α14, IFN-α6, IFN-α8, IFN-α9, IFN-β, IFN-γRα, IFN-ω, IgA2, IgAight chain, IgG, IL-1α, IL-1β, IL-12A p35, IL-12B p40, IL-1F6, IL-1Rrp2, IL-26, IL-28B, IL-33, IL-9, IL-TIFb, ILT-1, ILT-6, Influenza A ns1, Influenza B M1, IRF-1, IRF-3, IRF-7, ISG12a, ISG12b2, ISG15, ISG20, ISGF-3γ p48, KLH-A, KLRG1, KLRI1, La Crosse Virus G1, LAIR-2, LGALS9C, LGP2, LL-37, MASP-2, MD-2, MDA5, MHC class I, MHC class IIβ, MIP-1β, MIP-5, Mndal, Mucin 5AC, Mx1, Mx2, MxB, MyD88, NAIP1, NAIP5, NALP13, NALP14, NOD3, NOD9, Oas1c, OASL1, Optineurin, OTTMUSG00000011262, OTTMUSG00000011269, OTTMUSG00000016644, P2X7, PACT, Pellino 3, PKR, POP2, Properdin, REGIIIα, Rheumatoid Factor, RICK, RIG-I, RIP, RNase 6, RNase 7, RNase L, RP105, RT1-A, SAA1, Salmonella O, SAMD9, SARM, SID-1, SIKE, SIRP-β1b, Spi-B, TALL-1, TAP, TARM1, TBK1, TICAM-1, TICAM-2, TIM-3, TIM-4, TLR10, TLR13, TLR2, TLR3, TLR5, TLR6, TMEM119, TREM-1, TRIM11, TRIM34, TRIM36, TRIM43A, TRIM49, TRIM5α, TRIM52, TRIM56, TSLPR, Tyk 2, ULBP5, UNC93B1, Yersinia pestis F1, ZAP, and ZNF436.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Polyinosinic acid - polycytidylic acid sodium salt, double-stranded, 10 mg | sc-204854 | 10 mg | $139.00 | |||
Polyinosinic acid - polycytidylic acid sodium salt, double-stranded, 100 mg | sc-204854A | 100 mg | $663.00 |