MASP-2 Antibody (B-10): sc-390200

MASP-2 Antibody (B-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects MASP-2 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MASP-2 (B-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MASP-2 protein plays a crucial role in the immune system as MASP-2 is involved in the activation of the lectin pathway of the complement system, which is essential for the body′s defense against pathogens. Specifically, MASP-2 interacts with mannose-binding lectin (MBL) and other serine proteases to cleave and activate complement components, thereby enhancing opsonization and clearance of pathogens. This process is vital for initiating an effective immune response, as MASP-2 allows for the rapid targeting and neutralization of invading microorganisms. Furthermore, mutations in the MASP-2 gene can lead to immunodeficiencies, highlighting the importance of MASP-2 in maintaining immune system integrity. Anti-MASP-2 antibody (B-10) effectively detects and quantifies MASP-2, making anti-MASP-2 antibody (B-10) an invaluable tool for researchers studying immune responses and related disorders.

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MASP-2 Antibody (B-10) References:

1. Impaired secretion of rat mannose-binding protein resulting from mutations in the collagen-like domain.  |  Heise, CT., et al. 2000. J Immunol. 165: 1403-9. PMID: 10903744
2. Proteolytic activities of two types of mannose-binding lectin-associated serine protease.  |  Matsushita, M., et al. 2000. J Immunol. 165: 2637-42. PMID: 10946292
3. Interaction properties of human mannan-binding lectin (MBL)-associated serine proteases-1 and -2, MBL-associated protein 19, and MBL.  |  Thielens, NM., et al. 2001. J Immunol. 166: 5068-77. PMID: 11290788
4. Regulation of in situ complement activation via the lectin pathway in patients with IgA nephropathy.  |  Endo, M., et al. 2001. Clin Nephrol. 55: 185-91. PMID: 11316237
5. Stoichiometry of complexes between mannose-binding protein and its associated serine proteases. Defining functional units for complement activation.  |  Chen, CB. and Wallis, R. 2001. J Biol Chem. 276: 25894-902. PMID: 11337510
6. MASP-3 and its association with distinct complexes of the mannan-binding lectin complement activation pathway.  |  Dahl, MR., et al. 2001. Immunity. 15: 127-35. PMID: 11485744
7. Origin of mannose-binding lectin-associated serine protease (MASP)-1 and MASP-3 involved in the lectin complement pathway traced back to the invertebrate, amphioxus.  |  Endo, Y., et al. 2003. J Immunol. 170: 4701-7. PMID: 12707349
8. Characterization of recombinant mannan-binding lectin-associated serine protease (MASP)-3 suggests an activation mechanism different from that of MASP-1 and MASP-2.  |  Zundel, S., et al. 2004. J Immunol. 172: 4342-50. PMID: 15034049
9. Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) genotypes in colorectal cancer.  |  Ytting, H., et al. 2011. Scand J Immunol. 73: 122-7. PMID: 21198752
10. MASP-1 and MASP-2 Serum Levels Are Associated With Worse Prognostic in Cervical Cancer Progression.  |  Maestri, CA., et al. 2018. Front Immunol. 9: 2742. PMID: 30532757
11. Narsoplimab, a Mannan-Binding Lectin-Associated Serine Protease-2 Inhibitor, for the Treatment of Adult Hematopoietic Stem-Cell Transplantation-Associated Thrombotic Microangiopathy.  |  Khaled, SK., et al. 2022. J Clin Oncol. 40: 2447-2457. PMID: 35439028
12. Expression of H-ficolin/Hakata antigen, mannose-binding lectin-associated serine protease (MASP)-1 and MASP-3 by human glioma cell line T98G.  |  Kuraya, M., et al. 2003. Int Immunol. 15: 109-17. PMID: 12502731

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MASP-2 Antibody (B-10) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-MASP-2 Antibody (B-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MASP-2 Antibody (B-10) Specifications

Alternate Product Name: MASP-2

Product Clone Name: B-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 284-343

Epitope Target: MASP-2

Epitope Species: human

Product Reactivity/Detection: MASP-2 A chain

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for MASP-2 Antibody (B-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin