mAChR M1 Inhibitors
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Items 1 to 10 of 20 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
AQ-RA 741 | 123548-16-3 | sc-203517 sc-203517A | 10 mg 50 mg | $135.00 $575.00 | ||
AQ-RA 741 is a selective antagonist of the M1 muscarinic acetylcholine receptor, distinguished by its ability to stabilize receptor conformations that inhibit signaling. Its unique binding affinity is attributed to specific hydrophobic interactions and hydrogen bonding with key amino acid residues, which modulate receptor activity. The compound exhibits a distinctive kinetic profile, characterized by a slow off-rate, allowing for prolonged receptor occupancy and nuanced modulation of cholinergic pathways. | ||||||
Diphenhydramine hydrochloride | 147-24-0 | sc-204729 sc-204729A sc-204729B | 10 g 25 g 100 g | $51.00 $82.00 $122.00 | 4 | |
Diphenhydramine hydrochloride acts as a non-selective antagonist at the M1 muscarinic acetylcholine receptor, exhibiting a complex interaction profile. Its binding involves both electrostatic and hydrophobic forces, influencing receptor dynamics. The compound's unique structural features facilitate allosteric modulation, altering receptor conformation and downstream signaling pathways. Additionally, its reaction kinetics reveal a rapid association rate, contributing to its multifaceted impact on cholinergic neurotransmission. | ||||||
Atropine | 51-55-8 | sc-252392 | 5 g | $200.00 | 2 | |
Atropine is a competitive antagonist for the muscarinic acetylcholine receptors and may decrease expression by inhibiting receptor activation. | ||||||
Biperiden hydrochloride | 1235-82-1 | sc-203846 sc-203846A | 10 mg 50 mg | $112.00 $422.00 | ||
Biperiden hydrochloride selectively targets the M1 muscarinic acetylcholine receptor, showcasing a unique binding affinity that stabilizes specific receptor conformations. Its molecular structure promotes distinct hydrogen bonding interactions, enhancing receptor-ligand specificity. The compound exhibits notable reaction kinetics, characterized by a moderate dissociation rate, which influences the duration of its receptor engagement. This dynamic behavior contributes to its nuanced modulation of cholinergic signaling pathways. | ||||||
Scopolamine | 51-34-3 | sc-473216 sc-473216A sc-473216B | 100 mg 500 mg 1 g | $169.00 $496.00 $771.00 | 2 | |
As a non-selective muscarinic antagonist, scopolamine may downregulate receptor expression by blocking the receptor and reducing its activity. | ||||||
AF-DX 116 | 102394-31-0 | sc-223772 | 5 mg | $107.00 | 3 | |
AF-DX 116 is a selective antagonist of the M1 muscarinic acetylcholine receptor, exhibiting a unique interaction profile that alters receptor dynamics. Its molecular architecture facilitates specific electrostatic interactions, enhancing binding precision. The compound demonstrates rapid association kinetics, allowing for swift modulation of receptor activity. This behavior influences downstream signaling cascades, providing insights into cholinergic system regulation and receptor functionality. | ||||||
Telenzepine dihydrochloride | 147416-96-4 | sc-204332 sc-204332A | 10 mg 25 mg | $62.00 $128.00 | ||
Telenzepine dihydrochloride acts as a selective modulator of the M1 muscarinic acetylcholine receptor, characterized by its ability to stabilize receptor conformations. Its unique structural features promote distinct hydrogen bonding and hydrophobic interactions, which fine-tune receptor activation. The compound exhibits a notable affinity for allosteric sites, influencing receptor signaling pathways and enhancing the understanding of cholinergic neurotransmission dynamics. | ||||||
(S)-(+)-Dimethindene maleate | 121367-05-3 | sc-361329 sc-361329A | 10 mg 50 mg | $235.00 $960.00 | 1 | |
(S)-(+)-Dimethindene maleate is a selective antagonist of the M1 muscarinic acetylcholine receptor, exhibiting unique stereochemical properties that influence its binding affinity. Its molecular structure facilitates specific electrostatic interactions and steric hindrance, which modulate receptor activity. The compound's kinetic profile reveals a rapid onset of action, with distinct conformational changes in the receptor that alter downstream signaling cascades, providing insights into cholinergic modulation. | ||||||
Oxybutynin Chloride | 1508-65-2 | sc-208141 | 2.5 g | $265.00 | ||
Oxybutynin Chloride acts as a selective modulator of the M1 muscarinic acetylcholine receptor, characterized by its ability to induce conformational shifts in the receptor's structure. This compound engages in specific hydrogen bonding and hydrophobic interactions, enhancing its binding efficacy. Its unique kinetic behavior allows for a nuanced regulation of receptor-mediated pathways, influencing downstream cellular responses and contributing to the complexity of cholinergic signaling. | ||||||
4-DAMP | 1952-15-4 | sc-200167 | 50 mg | $192.00 | 5 | |
4-DAMP is a potent antagonist of the M1 muscarinic acetylcholine receptor, exhibiting a high affinity for the receptor's orthosteric site. Its unique structure facilitates specific electrostatic interactions, which stabilize the receptor-ligand complex. The compound's kinetic profile reveals rapid association and dissociation rates, allowing for dynamic modulation of receptor activity. This behavior underscores its role in fine-tuning cholinergic signaling pathways, impacting various cellular processes. | ||||||