Biperiden hydrochloride is a muscarinic receptor (mAChR M) antagonist that displays some selectivity for the mAChR M1 subtype (Ki values are 0.48, 2.4, 3.9, 6.3 and 6.3 nM for mAChR M1, mAChR M4, mAChR M3, mAChR M2 and mAChR M5 receptors, respectively).
Bolden et al (1992) Antagonism by antimuscarinic and neuroleptic compounds at the five cloned human muscarinic cholinergic receptors expressed in chinese hamster ovary cells. J.Pharmacol.Exp.Ther. 260 576. Sudo et al (1999) Muscarinic receptor occupancy by biperiden in living human brain. Life Sci. 64 PL99. Brocks (1999) Anticholienrgic drugs used in Parkinson's disease: an overlooked class of drugs from a pharmacokinetic perspective. J.Pharm.Pharmaceut.Sci. 2 39.
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