mAChR M1 Antibody (G-9): sc-365966

mAChR M1 Antibody (G-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects mAChR M1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-mAChR M1 antibody (G-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The muscarinic acetylcholine receptor M1 (mAChR M1) plays a crucial role in mediating cellular responses, such as adenylate cyclase inhibition and potassium channel modulation, which maintain cellular homeostasis and facilitate neuron communication. mAChR M1 is primarily located in the central nervous system and peripheral tissues, where mAChR M1 influences cognitive functions, memory, and autonomic nervous system responses. mAChR M1 belongs to the G-protein coupled receptor family, featuring seven transmembrane domains and a unique intracellular region that interacts with specific G-proteins to initiate downstream signaling pathways. Understanding mAChR M1′s function and location is vital for elucidating its role in various physiological processes and potential implications in neurological disorders.

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mAChR M1 Antibody (G-9) References:

1. Muscarinic acetylcholine receptors: structure and function.  |  Hulme, EC., et al. 1991. Biochem Soc Trans. 19: 133-8. PMID: 1903735
2. Muscarinic acetylcholine receptors: typical G-coupled receptors.  |  Hulme, EC. 1990. Symp Soc Exp Biol. 44: 39-54. PMID: 2130518
3. Molecular cloning and expression of a fifth muscarinic acetylcholine receptor.  |  Liao, CF., et al. 1989. J Biol Chem. 264: 7328-37. PMID: 2540186
4. Primary structure and biochemical properties of an M2 muscarinic receptor.  |  Peralta, EG., et al. 1987. Science. 236: 600-5. PMID: 3107123
5. Loss of Cholinergic Receptor Muscarinic 1 (CHRM1) Protein in the Hippocampus and Temporal Cortex of a Subset of Individuals with Alzheimer's Disease, Parkinson's Disease, or Frontotemporal Dementia: Implications for Patient Survival.  |  Sabbir, MG., et al. 2022. J Alzheimers Dis. 90: 727-747. PMID: 36155524
6. The investigation of cholinergic receptor muscarinic 1 activity in the rat ovary with induced ovarian hyperstimulation.  |  Şanlı, C., et al. 2023. Turk J Obstet Gynecol. 20: 53-58. PMID: 36908094
7. Hippocampal versus cortical deletion of cholinergic receptor muscarinic 1 in mice differentially affects post-translational modifications and supramolecular assembly of respiratory chain-associated proteins, mitochondrial ultrastructure, and respiration: implications in Alzheimer's disease.  |  Sabbir, MG., et al. 2023. Front Cell Dev Biol. 11: 1179252. PMID: 37293125
8. Cholinergic Receptor Muscarinic 1 Co-Localized with Mitochondria in Cultured Dorsal Root Ganglion Neurons, and Its Deletion Disrupted Mitochondrial Ultrastructure in Peripheral Neurons: Implications in Alzheimer's Disease.  |  Sabbir, MG. 2024. J Alzheimers Dis. 98: 247-264. PMID: 38427478
9. Muscarinic receptors--characterization, coupling and function.  |  Caulfield, MP. 1993. Pharmacol Ther. 58: 319-79. PMID: 7504306
10. Muscarinic acetylcholine receptor subtypes: localization and structure/function.  |  Brann, MR., et al. 1993. Prog Brain Res. 98: 121-7. PMID: 8248499
11. Distribution of muscarinic receptor subtypes in rat brain from postnatal to old age.  |  Tice, MA., et al. 1996. Brain Res Dev Brain Res. 92: 70-6. PMID: 8861724
12. Pharmacology of muscarinic acetylcholine receptor subtypes (m1-m5): high throughput assays in mammalian cells.  |  Bräuner-Osborne, H. and Brann, MR. 1996. Eur J Pharmacol. 295: 93-102. PMID: 8925880

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-mAChR M1 Antibody (G-9) has 14 citations in a variety of scientific publications.

Primary antibodies like Anti-mAChR M1 Antibody (G-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

mAChR M1 Antibody (G-9) Specifications

Alternate Product Name: CHRM1

Product Clone Name: G-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 231-350

Epitope Target: mAChR M1

Epitope Species: human

Product Reactivity/Detection: mAChR M1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 14 citations in various scientific publications

Available Conjugates/Forms for mAChR M1 Antibody (G-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin