Molecular structure of 4-DAMP, CAS Number: 1952-15-4
4-DAMP (CAS 1952-15-4)
See product citations (5)
Application:
4-DAMP is an antagonist of mAChR M3
CAS Number:
1952-15-4
Purity:
98%
Molecular Weight:
451.4
Molecular Formula:
C21H26INO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
4-DAMP, or 4-diphenylacetoxy-N-methyl-piperidine methiodide, is an antagonist at the M3 muscarinic receptor. A deuterated [3H]4-DAMP derivative was demonstrated to bind the M1 and M3 muscarinic receptors with high affinity, and the M2 receptor with low affinity. Blockade of the M2 muscarinic receptor by 4-DAMP produced a dose-dependent reduction of blood pressure in spotaneously hypertensive rats.
4-DAMP (CAS 1952-15-4) References
- Erk1/2- and p38 MAP kinase-dependent phosphorylation and activation of cPLA2 by m3 and m2 receptors. | Zhou, H., et al. 2003. Am J Physiol Gastrointest Liver Physiol. 284: G472-80. PMID: 12576304
- The antiarrhythmic effect and possible ionic mechanisms of pilocarpine on animal models. | Zhao, WM., et al. 2009. J Cardiovasc Pharmacol Ther. 14: 242-7. PMID: 19721134
- Activation of cardiac muscarinic M3 receptors induces delayed cardioprotection by preserving phosphorylated connexin43 and up-regulating cyclooxygenase-2 expression. | Zhao, J., et al. 2010. Br J Pharmacol. 159: 1217-25. PMID: 20128816
- Activation of M3 muscarinic receptors inhibits T-type Ca(2+) channel currents via pertussis toxin-sensitive novel protein kinase C pathway in small dorsal root ganglion neurons. | Zhang, Y., et al. 2011. Cell Signal. 23: 1057-67. PMID: 21329754
- Muscarinic activation of Ca2+-activated Cl- current in interstitial cells of Cajal. | Zhu, MH., et al. 2011. J Physiol. 589: 4565-82. PMID: 21768263
- Peculiar effects of muscarinic M1, M2, and M3 receptor blockers on cardiac chronotropic function in neonatal rats. | Ziyatdinova, NI., et al. 2012. Bull Exp Biol Med. 154: 1-2. PMID: 23330075
- Choline protects against cardiac hypertrophy induced by increased after-load. | Zhao, Y., et al. 2013. Int J Biol Sci. 9: 295-302. PMID: 23493786
- Jujuboside B Reduces Vascular Tension by Increasing Ca2+ Influx and Activating Endothelial Nitric Oxide Synthase. | Zhao, Y., et al. 2016. PLoS One. 11: e0149386. PMID: 26901291
- Direct labeling of rat M3-muscarinic receptors by [3H]4DAMP. | Michel, AD., et al. 1989. Eur J Pharmacol. 166: 459-66. PMID: 2806372
- Choline Attenuates Cardiac Fibrosis by Inhibiting p38MAPK Signaling Possibly by Acting on M3 Muscarinic Acetylcholine Receptor. | Zhao, L., et al. 2019. Front Pharmacol. 10: 1386. PMID: 31849653
- Blockade of brain M2 muscarinic receptors lowers blood pressure in spontaneously hypertensive rats. | Brezenoff, HE., et al. 1988. Pharmacology. 36: 101-5. PMID: 3353437
- A further search for selective antagonists at M2-muscarinic receptors. | Barlow, RB. and Shepherd, MK. 1986. Br J Pharmacol. 89: 837-43. PMID: 3814912
- Muscarinic receptor subtypes controlling the cationic current in guinea-pig ileal smooth muscle. | Zholos, AV. and Bolton, TB. 1997. Br J Pharmacol. 122: 885-93. PMID: 9384504
Inhibitor of:
mAChR M1, mAChR M2, mAChR M3, mAChR M4, and mAChR M5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-DAMP, 50 mg | sc-200167 | 50 mg | $196.00 |