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Diphenhydramine hydrochloride (CAS 147-24-0)

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Alternate Names:
2-benzhydryloxy-N,N-dimethylethanamine HCl
Application:
Diphenhydramine hydrochloride is a histamine H1-receptor antagonist
CAS Number:
147-24-0
Purity:
≥98%
Molecular Weight:
291.82
Molecular Formula:
C17H21NO•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Diphenhydramine hydrochloride is an organic compound extensively studied in the context of its antihistaminic properties, particularly its ability to bind to and inhibit the H1 histamine receptor. This binding affinity is the focus of research examining the modulation of histamine-mediated pathways, as histamine plays a significant role in immune responses and the regulation of physiological functions in the body. In addition to its receptor interactions, studies involving Diphenhydramine hydrochloride also investigate its effects on acetylcholine receptors, which contribute to its anticholinergic activity. The compound′s influence on the central nervous system, such as its sedative effects, is another area of research interest. Moreover, Diphenhydramine hydrochloride is used in the development of analytical methods to detect and quantify similar organic compounds in various matrices, due to its characteristic chemical structure and properties.


Diphenhydramine hydrochloride (CAS 147-24-0) References

  1. History of modern psychopharmacology: a personal view with an emphasis on antidepressants.  |  Domino, EF. 1999. Psychosom Med. 61: 591-8. PMID: 10511010
  2. Block of sodium currents in rat dorsal root ganglion neurons by diphenhydramine.  |  Kim, YS., et al. 2000. Brain Res. 881: 190-8. PMID: 11036158
  3. A toxicologic study of two histamine antagonists of the benzhydryl alkamine ether group.  |  GRUHZIT, OM. and FISKEN, RA. 1947. J Pharmacol Exp Ther. 89: 227-33. PMID: 20290426
  4. Effects of antihistamines on phorbol ester tumor promotion and vascular permeability changes.  |  Fischer, SM., et al. 1990. Carcinogenesis. 11: 991-6. PMID: 2112062
  5. Fast determination of diphenhydramine hydrochloride in reconstitutable syrups by CWT, PLS AND PCR methods.  |  Devrim, B., et al. 2014. Acta Pol Pharm. 71: 721-9. PMID: 25362800
  6. Stability of Diphenhydramine Hydrochloride, Lorazepam, and Dexamethasone Sodium Phosphate in 0.9% Sodium Chloride Stored in Polypropylene Syringes.  |  Anderson, CR., et al. 2015. Int J Pharm Compd. 19: 344-7. PMID: 26625573
  7. Co-amorphous Formation Induced by Combination of Tranilast and Diphenhydramine Hydrochloride.  |  Ueda, H., et al. 2017. J Pharm Sci. 106: 123-128. PMID: 27539557
  8. Disulfiram and Diphenhydramine Hydrochloride Upregulate miR-30a to Suppress IL-17-Associated Autoimmune Inflammation.  |  Zhao, M., et al. 2016. J Neurosci. 36: 9253-66. PMID: 27581464
  9. Percutaneous Absorption of Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol from ABH Gel.  |  Dahal, A., et al. 2020. Int J Pharm Compd. 24: 168-175. PMID: 32196480
  10. Design of a Stable Coamorphous System Using Lactose as an Antiplasticizing Agent for Diphenhydramine Hydrochloride with a Low Glass Transition Temperature.  |  Ueda, H., et al. 2022. Mol Pharm. 19: 1209-1218. PMID: 35316068
  11. Diphenhydramine hydrochloride; its use as a local anesthetic in dentistry.  |  Malamed, SF. 1973. Anesth Prog. 20: 76-82. PMID: 4513854
  12. Diphenhydramine hydrochloride helps symptoms of ciguatera fish poisoning.  |  Savaloja, J. 1996. J Emerg Nurs. 22: 373. PMID: 8997960
  13. Pharmacokinetics and pharmacodynamics of diphenhydramine 25 mg in young and elderly volunteers.  |  Scavone, JM., et al. 1998. J Clin Pharmacol. 38: 603-9. PMID: 9702844

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Diphenhydramine hydrochloride, 10 g

sc-204729
10 g
$51.00

Diphenhydramine hydrochloride, 25 g

sc-204729A
25 g
$82.00

Diphenhydramine hydrochloride, 100 g

sc-204729B
100 g
$122.00