LRRN2 Activators
LRRN2 Activators represent a class of compounds that influence various cellular signaling pathways, leading to the enhanced functional activity of the protein LRRN2. Forskolin, by increasing cAMP levels, and Isoproterenol, as a beta-adrenergic agonist, enhance PKA activity. PKA is a kinase that can phosphorylate multiple substrates, including those that regulate or interact with LRRN2, which may enhance the activity of LRRN2. Similarly, IBMX and Dibutyryl-cAMP elevate cAMP levels, thereby indirectly promoting the activation of LRRN2 through PKA-mediated phosphorylation events. Ionophores like Ionomycin and A23187, as well as inhibitors like Thapsigargin, alter intracellular calcium levels. Calcium is a secondary messenger that activates various kinases, such as calmodulin-dependent kinase, which could influence the functional activityof LRRN2 through calcium-dependent signaling pathways. BAPTA-AM, by modulating intracellular calcium, also plays a role in fine-tuning these calcium-mediated pathways, leading to an enhancement of LRRN2 activity.
Phorbol esters like PMA are known to activate PKC, which phosphorylates a wide range of substrates, leading to the activation of multiple signaling pathways. By activating PKC, PMA could indirectly enhance the functional activity of LRRN2 through PKC-mediated signaling events. The polyamine spermine, by modulating ion channels and intracellular signaling cascades, can indirectly influence the activity of LRRN2 as well. LY294002, a PI3K inhibitor, alters the phosphorylation status of downstream targets within the PI3K pathway, which could intersect with LRRN2-related pathways, leading to its activation. EGCG, through its modulation of oxidative stress-related pathways, can indirectly affect the activity of LRRN2.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing levels of cAMP, which can enhance PKA activity. PKA can then phosphorylate target proteins that may interact with or regulate LRRN2, thereby potentially enhancing its functional activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels. Elevated calcium can activate calmodulin-dependent kinase (CaMK), which may affect proteins associated with LRRN2 and enhance its activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is an activator of protein kinase C (PKC). PKC, when activated, can phosphorylate various substrates that may interact with or regulate LRRN2, potentially enhancing its activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is another calcium ionophore that increases intracellular calcium concentration, potentially activating calcium-dependent pathways that can interact with or regulate LRRN2, enhancing its activity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases cAMP levels, thereby activating PKA. PKA may phosphorylate substrates implicated in the regulation of LRRN2, leading to its functional enhancement. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, leading to increased cAMP levels. Elevated cAMP can enhance PKA activity, which could phosphorylate proteins involved in the regulation of LRRN2. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
BAPTA-AM is a cell-permeable calcium chelator that can modulate calcium signaling pathways. By fine-tuning calcium levels, it may indirectly enhance signaling pathways involving LRRN2. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable analog of cAMP that can activate PKA. PKA subsequently may phosphorylate regulatory proteins connected with LRRN2, potentially enhancing its activity. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to increased cytosolic calcium levels. Elevated calcium can activate signaling pathways that may enhance the activity of LRRN2. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG can modulate various signaling pathways, including those related to oxidative stress. By influencing these pathways, EGCG may indirectly enhance the functional activity of LRRN2. | ||||||