LAL Activators
The chemical class of LAL Activators encompasses a variety of compounds that indirectly stimulate the activity of Lysosomal Acid Lipase, a key enzyme in lipid metabolism within the lysosome. These activators primarily function by modulating metabolic pathways that influence the breakdown of lipids, thus potentially enhancing LAL activity. The class includes several compounds that increase cAMP levels, such as Forskolin, Isoproterenol, Cilostazol, and IBMX. Elevated cAMP is known to impact lipid metabolism, potentially leading to increased demand and activity of LAL for the hydrolysis of cholesteryl esters and triglycerides.
Additionally, this class incorporates agents that directly influence lipid metabolism, like Nicotinic Acid and Clofibrate, which are known to affect lipid profiles and could indirectly lead to enhanced LAL activity. PPAR-gamma agonists, represented by Rosiglitazone and Pioglitazone, also play a significant role in lipid metabolism regulation, which can indirectly impact LAL activity. Moreover, statins such as Atorvastatin and Simvastatin, widely used to manage cholesterol levels, may influence LAL activity through their broad effects on cholesterol homeostasis.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased cAMP levels, which can influence lipid metabolism and potentially enhance LAL activity. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $116.00 $179.00 $265.00 $369.00 $629.00 $1150.00 | ||
Elevated cAMP levels, achieved through various means, can modulate lipid metabolism pathways, potentially leading to increased LAL activity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
A beta-adrenergic agonist that increases cAMP levels, potentially enhancing lipid metabolism and indirectly stimulating LAL activity. | ||||||
Cilostazol | 73963-72-1 | sc-201182 sc-201182A | 10 mg 50 mg | $109.00 $322.00 | 3 | |
A phosphodiesterase inhibitor that raises cAMP levels, potentially influencing lipid metabolism and indirectly activating LAL. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
A nonspecific inhibitor of phosphodiesterases, leading to increased cAMP levels, which might enhance LAL activity indirectly by affecting lipid metabolism. | ||||||
Nicotinic Acid | 59-67-6 | sc-205768 sc-205768A | 250 g 500 g | $62.00 $124.00 | 1 | |
Known to influence lipid metabolism, potentially affecting the activity of enzymes like LAL. | ||||||
Clofibrate | 637-07-0 | sc-200721 | 1 g | $33.00 | ||
A fibrate drug that can modulate lipid metabolism, potentially leading to increased LAL activity. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
A PPAR-gamma agonist that influences lipid metabolism and could indirectly enhance LAL activity. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $55.00 $125.00 | 13 | |
Similar to Rosiglitazone, Pioglitazone acts as a PPAR-gamma agonist and can influence lipid metabolism, potentially affecting LAL activity. | ||||||
Atorvastatin | 134523-00-5 | sc-337542A sc-337542 | 50 mg 100 mg | $257.00 $505.00 | 9 | |
A statin that affects cholesterol metabolism, potentially leading to changes in LAL activity as part of the compensatory mechanisms. | ||||||