Molecular structure of Clofibrate, CAS Number: 637-07-0
Clofibrate (CAS 637-07-0)
Application:
Clofibrate is a biochemical that induces cytochrome P450 IVA1 and IVA3
CAS Number:
637-07-0
Purity:
≥99%
Molecular Weight:
242.70
Molecular Formula:
C12H15ClO3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Clofibrate is a ligand agonist for PPARalpha (peroxisome proliferator-activated receptor alpha), or an inducer of cytochromes P450′s CYP4A1 and CYP4A3. In studies utilizing rats treated with Clofibrate, cytochromes CYP4A1 and CYP4A3 are reported to be expressed in the liver. Further studies of CYP4A1 and CYP4A3 expression in rat liver indicated that these enzymes are able to catalyze oxidation of fatty acids and prostaglandins. Also offered as a deuterium-labelled compound, Clofibrate-d4 (sc-217930)
Clofibrate (CAS 637-07-0) References
- Effect of clofibrate on malic enzyme and leptin mRNAs level in rat brown and white adipose tissue. | Kochan, Z., et al. 1999. Horm Metab Res. 31: 538-42. PMID: 10596961
- Differential effect of clofibrate on acetyl-CoA carboxylase mRNA level in rat white and brown adipose tissue. | Karbowska, J., et al. 2000. Life Sci. 66: 545-52. PMID: 10794071
- Effects of peroxisome proliferators gemfibrozil and clofibrate on syntheses of dolichol and cholesterol in rat liver. | Shiota, Y., et al. 2003. J Biochem. 134: 197-202. PMID: 12966067
- Proteomic characterization of the effects of clofibrate on protein expression in rat liver. | Léonard, JF., et al. 2006. Proteomics. 6: 1915-33. PMID: 16470657
- Differential effects of pyrazinamide and clofibrate on gene expression of rat hepatic alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase, a key enzyme of the tryptophan-NAD pathway. | Egashira, Y., et al. 2006. Int J Vitam Nutr Res. 76: 138-46. PMID: 17048193
- Clofibrate prevents and reverses the hemodynamic manifestations of hyperthyroidism in rats. | Rodríguez-Gómez, I., et al. 2008. Am J Hypertens. 21: 341-7. PMID: 18219302
- Effect of clofibrate treatment on hepatic prostaglandin catabolism and action. | Brass, EP. and Ruff, LJ. 1991. J Pharmacol Exp Ther. 257: 1034-8. PMID: 2046019
- Regulation of liver fatty acid binding protein expression by clofibrate in hepatoma cells. | Yan, J., et al. 2010. Biochem Cell Biol. 88: 957-67. PMID: 21102658
- Clofibrate-inducible rat hepatic P450s IVA1 and IVA3 catalyze the omega- and (omega-1)-hydroxylation of fatty acids and the omega-hydroxylation of prostaglandins E1 and F2 alpha. | Aoyama, T., et al. 1990. J Lipid Res. 31: 1477-82. PMID: 2280187
- Cytoprotective effects of silafibrate, a newly-synthesised siliconated derivative of clofibrate, against acetaminophen-induced toxicity in isolated rat hepatocytes. | Nafisi, S., et al. 2014. Arh Hig Rada Toksikol. 65: 169-78. PMID: 24706421
- Pilot studies evaluating the nongenotoxic rodent carcinogens phenobarbital and clofibrate in the rat Pig-a assay. | Ji, Z., et al. 2019. Environ Mol Mutagen. 60: 42-46. PMID: 30338550
- Clofibrate Treatment Decreases Inflammation and Reverses Myocardial Infarction-Induced Remodelation in a Rodent Experimental Model. | Ibarra-Lara, L., et al. 2019. Molecules. 24: PMID: 30642049
- Mitochondrial and peroxisomal fatty acid oxidation in liver homogenates and isolated hepatocytes from control and clofibrate-treated rats. | Mannaerts, GP., et al. 1979. J Biol Chem. 254: 4585-95. PMID: 438207
- Change of the sex-dependent response to clofibrate in F344 rat liver during postnatal development. | Yamoto, T., et al. 1996. Toxicol Lett. 85: 77-83. PMID: 8650696
Inhibitor of:
ABCD1, ACOT12, ACOX3, ACSVL3, APOP1, C20orf79, CYP2C8, CYP4A22, Cyp4f13, CYP4F2, E230019M04Rik, ECH1, EG666803, FA2H, HACL1, HAO1, ILBP, L-FABP, Nir2, NPT1, PECR, Peroxin 1, Peroxin 11α, Peroxin 2, Pex13p, Pex14p, Pex5p, Pex7p, PHYHD1, plasmolipin, Pmp34, RCK, SCP-2, SEC14L2, SgK223, SLC17A (solute carrier family 17), SLC17A2, SLC25A29, STARD, and StARD10.Activator of:
17β-HSD11, 2900097C17Rik, AADACL1, ABCA, ABCD2, ABHD14A, ACBP, ACOT2, ACOT9, ACOX1, ACOX2, ACSBG2, ACSL1, Ah Receptor, ALB, apoC-I, apoM, ARG-Vasopressin, ARL15, B-Myb, CEACAM1, Ces1a, Ces1d, Ces1g, CES2, CES4, CES7, Cholesterol Esterase, COQ10A, CPTI-L, CYP, CYP27C1, CYP2AB1, CYP2B1, CYP2B10, CYP2B13, CYP2B19, CYP2B2, CYP2B6, CYP2B9, Cyp2c39, Cyp2c54, CYP2D40, CYP2J2, CYP2J6, CYP2J7, CYP2U1, CYP39A1, Cyp3a13, CYP4A, CYP4A1, CYP4A11, CYP4A12B, CYP4A14, CYP4A29, CYP4A30B, CYP4A32, CYP4F11, CYP4F12, Cyp4f37, Cyp4f39, CYP4F8, CYP4V2, CYP4X1, CYP4Z1, CYP7A1, CYP7B1, Cypt2, DAF-12, DECR2, E-FABP, ECH1, EG624219, EHHADH, EPHX2, ERAL1, FACL5, FADS2, GRAMD1C, HADHB, LAL, LIMP II, Lipin-2, Lipocalin-3, LIPT2, Lmf1, LOC100039269, LOC730005, LPAAT-η, LPD lipase, MCAD, MCCB, mEH, MENTHO, MTMR5, MUP, NDRG2, NRIP2, OATP-C, Oatp-Y, OATP16, Oatp5, OATP8, ORP-2, ORP-5, P76, PAP-2b, PECI, Peroxin 10, Peroxin 11γ, Peroxin 12, Peroxin 13, Peroxin 16, Peroxin 5R, Peroxin 6, Peroxin 7, Peroxisome 26, PIPOX, PLBD1, Pmp24, PPAR alpha, Pxmp2, Rab 17, SEC14L3, SLC22A29, SLC25A20, SLC43A2, Sodium Taurochenodeoxycholate, SR-B1, T-FABP, TMEM195, TYSND1, UGT1A10, UGT1A3, UGT1A4, UGT2A3, UGT2B10, UGT2B11, UGT2B28, UGT2B4, UGT3A1, and VACVase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Clofibrate, 1 g | sc-200721 | 1 g | $32.00 |