LAL Inhibitors
LAL Inhibitors consist of a diverse range of compounds that indirectly suppress the activity of Lysosomal Acid Lipase, an enzyme critical for lipid degradation within lysosomes. This class includes both direct inhibitors, such as Lalistat, and compounds that modulate lysosomal function or pH, such as Chloroquine, Hydroxychloroquine, and Bafilomycin A1. These compounds affect the optimal acidic environment required for LAL's enzymatic activity, leading to its inhibition.
Additionally, this class encompasses various drugs known to impact lysosomal function, including tricyclic antidepressants like Imipramine and Desipramine, and SSRIs such as Sertraline and Fluoxetine. Their ability to disrupt lysosomal acidification can lead to the indirect inhibition of LAL. Amiodarone and Tamoxifen, known for their lysosomal accumulation, also contribute to this class by inhibiting lysosomal enzymes like LAL. Furthermore, compounds that influence cholesterol metabolism, such as Progesterone and Lovastatin, may indirectly affect LAL activity by altering its substrate availability or regulatory mechanisms.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
An antimalarial drug known to raise lysosomal pH, which can inhibit lysosomal enzymes like LAL by altering their optimal acidic environment. | ||||||
hydroxychloroquine | 118-42-3 | sc-507426 | 5 g | $57.00 | 1 | |
Similar to Chloroquine, Hydroxychloroquine can increase lysosomal pH, potentially inhibiting LAL activity. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
An inhibitor of the vacuolar-type H+-ATPase (V-ATPase), which can increase lysosomal pH and potentially inhibit lysosomal enzymes including LAL. | ||||||
Imipramine hydrochloride | 113-52-0 | sc-207753 sc-207753B sc-207753A | 100 mg 1 g 5 g | $26.00 $45.00 $103.00 | 5 | |
A tricyclic antidepressant that can disrupt lysosomal acidification, potentially leading to the inhibition of LAL. | ||||||
Amiodarone | 1951-25-3 | sc-480089 | 5 g | $318.00 | ||
An agent in research used for a number of types of irregular heartbeats, known to accumulate in lysosomes and potentially inhibit their function, including LAL activity. | ||||||
Desipramine hydrochloride | 58-28-6 | sc-200158 sc-200158A | 100 mg 1 g | $66.00 $117.00 | 6 | |
Another tricyclic antidepressant that can affect lysosomal function, potentially leading to the inhibition of LAL. | ||||||
Fluoxetine | 54910-89-3 | sc-279166 | 500 mg | $318.00 | 9 | |
Similar to Sertraline, Fluoxetine is an SSRI that can affect lysosomal function, potentially leading to LAL inhibition. | ||||||
Progesterone | 57-83-0 | sc-296138A sc-296138 sc-296138B | 1 g 5 g 50 g | $20.00 $52.00 $298.00 | 3 | |
A hormone that can affect cholesterol metabolism and potentially influence LAL activity indirectly. | ||||||
Tamoxifen | 10540-29-1 | sc-208414 | 2.5 g | $272.00 | 18 | |
A selective estrogen receptor modulator that can accumulate in lysosomes and potentially affect their function, including the inhibition of LAL. | ||||||
Lovastatin | 75330-75-5 | sc-200850 sc-200850A sc-200850B | 5 mg 25 mg 100 mg | $29.00 $90.00 $339.00 | 12 | |
While primarily a cholesterol-lowering agent, Lovastatin may influence cholesterol metabolism in a way that affects LAL activity indirectly. | ||||||