Desipramine hydrochloride (CAS 58-28-6)
Desipramine HCl is a selective inhibitor of noradrenaline the transporters norepinephrine transporter (SLC6A2 or NET; Ki = 4 nM), serotonin transporter (ST or SERT; Ki = 61 nM), and dopamine transporter (DAT; Ki = 78,720 nM). This compound is a potent inhibitor of the norepinephrine transporter, and also blocks serotonin re-uptake. This compound has also been shown to reverse the pro-apoptotic effect of chronic unpredictable mild stress in the rat cerebral cortex, although it induces apoptosis in several cancer cell lines. It has also been shown to display antiinflammatory activity in a rat colitis model.
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