Molecular structure of Nicotinic Acid, CAS Number: 59-67-6
Nicotinic Acid (CAS 59-67-6)
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Alternate Names:
Niacin
Application:
Nicotinic Acid is a major chemical component of coenzymes NAD+ and NADP+
CAS Number:
59-67-6
Purity:
99%
Molecular Weight:
123.1
Molecular Formula:
C6H5NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Nicotinic Acid is a compound of interest in numerous biochemical and nutritional research areas. It serves as a precursor to nicotinamide adenine dinucleotide (NAD) and its phosphate form (NADP), which are vital coenzymes in oxidative-reductive reactions across all forms of life. In biochemical assays, Nicotinic Acid is used to study these coenzymes′ roles in electron transfer processes and their involvement in the metabolic pathways, such as glycolysis, fatty acid synthesis, and the citric acid cycle. Research involving Nicotinic Acid also encompasses the examination of its impact on lipid metabolism, which is significant for understanding cell membrane synthesis and energy storage mechanisms. Additionally, it is employed in the exploration of gene expression regulation, as NAD-dependent enzymes, like sirtuins, are known to modify histones and influence chromatin structure.
Nicotinic Acid (CAS 59-67-6) References
- Management of the metabolic syndrome-nicotinic acid. | Meyers, CD. and Kashyap, ML. 2004. Endocrinol Metab Clin North Am. 33: 557-75, vii. PMID: 15262297
- Nicotinic acid: the broad-spectrum lipid drug. A 50th anniversary review. | Carlson, LA. 2005. J Intern Med. 258: 94-114. PMID: 16018787
- Nicotinic acid and other therapies for raising high-density lipoprotein. | Carlson, LA. 2006. Curr Opin Cardiol. 21: 336-44. PMID: 16755203
- Nicotinic acid: pharmacological effects and mechanisms of action. | Gille, A., et al. 2008. Annu Rev Pharmacol Toxicol. 48: 79-106. PMID: 17705685
- Nicotinic acid: an old drug with a promising future. | Bodor, ET. and Offermanns, S. 2008. Br J Pharmacol. 153 Suppl 1: S68-75. PMID: 18037924
- Nicotinic acid + larodiorant. Laropiprant adds its own adverse effects. | . 2010. Prescrire Int. 19: 9-11. PMID: 20455330
- New evidence for nicotinic acid treatment to reduce atherosclerosis. | Montecucco, F., et al. 2010. Expert Rev Cardiovasc Ther. 8: 1457-67. PMID: 20936932
- Nicotinic acid as a lipid-modifying drug--a review. | Julius, U. and Fischer, S. 2013. Atheroscler Suppl. 14: 7-13. PMID: 23357134
- Nicotinic acid and its derivatives: synthetic routes, crystal forms and polymorphs. | Zhou, PP., et al. 2014. Curr Drug Discov Technol. 11: 97-108. PMID: 24568240
- Definition of a tolerable upper intake level of niacin: a systematic review and meta-analysis of the dose-dependent effects of nicotinamide and nicotinic acid supplementation. | Minto, C., et al. 2017. Nutr Rev. 75: 471-490. PMID: 28541582
- Nicotinic acid: a review of its clinical use in the treatment of lipid disorders. | Figge, HL., et al. 1988. Pharmacotherapy. 8: 287-94. PMID: 3075276
- Nicotinic acid supplementation at a supraphysiological dose increases the bioavailability of NAD+ precursors in mares. | Pollard, CL., et al. 2021. J Anim Physiol Anim Nutr (Berl). 105: 1154-1164. PMID: 34117670
- Methods to Produce Nicotinic Acid with Potential Industrial Applications. | Lisicki, D., et al. 2022. Materials (Basel). 15: PMID: 35160711
- An improved process for synthesis of nicotinic acid using hyper induced whole cell nitrilase of Gordonia terrae MTCC8139. | Monika, ., et al. 2022. 3 Biotech. 12: 303. PMID: 36276445
- Nicotinic acid and its derivatives: a short survey. | Hotz, W. 1983. Adv Lipid Res. 20: 195-217. PMID: 6322545
Inhibitor of:
ABCG1, ABCG5, ABHD3, ACMSD, ACOT10, ACOT2, ACOT3, ACOT4, ACOT8, ACSM4, AdipoR1, AMAC1L2, Angptl3, APO, apoA-IV, apoAL, apoB48R, apoC-III, apoC1, apoE, ApoER2, APOL (Apolipoprotein L), apoL-VI, apoM, APOP1, C20orf79, CROT, DDHD2, DECR1, DSCD75, ECHDC2, EG624219, EG666803, ELOVL (ELOngation of Very Long chain fatty acids), Endothelial Lipase, FA2H, FIT1, FMO1, GPIHBP1, GRAMD1A, Hepatic Lipase, HM74B, ITPK1, LDLRAD2, LIP1, Lipin-3, Lmf2, LPAAT-ε, MMADHC, NPT2c, OAT6, OATP-E, OATP2A1, Olfr816, PCCB, PDSS2, PDZK1, Plb3, PON2, SCP-2, SCP2D1, SEC14L2, SEC14L3, SEC14L4, STARD, StARD10, SVCT3, and T-FABP.Activator of:
α-KGD, 0610007N19Rik, 4930432K09Rik, 5α-Reductase 2, AADACL1, AADACL2, ABHD12, ABHD14A, ABHD3, ACBD4, ACBP, ACSL3, ACSM2B, ADH5, ADH6, AI462493, ALDH1L1, Ang-4, apoA-V, apoC-I, apoC-II, apoC1, apoF, AQP7, ARH3, ART1, ART2A, ART2B, ATGL, B-FABP, BBS1, Bordetella pertussis toxin, C10orf67, C14orf105, C14orf176, C330021F23Rik, C5orf32, C6orf105, C6orf118, C6orf126, C85492, C8orf80, CaMK1G, CCDC109A, CCDC125, CCL27, CECR5, CH25H, Cholesterol Esterase, CHPT1, Chromozym t-PA, CIDE-A, CMV gB, COQ2, CRF21, CRP, CT-R, CTHRC1, CYB5D1, CYP27A1, CYP4A14, Dab1, DDHD1, DHRS13, dinitrophenol, DNA pol δ 4, DNA pol ν, DNAH1, DONSON, Dopey-1, DPYD, DSC2, DSCD75, DSCR 3, DUSP27, E2F-5, EF-CAB9, EG329055, EG624439, EG624584, EG666955, EG667512, EG668114, EHHADH, EMSY, FACL6, FAM122B, FAM159A, FAM47C, FATP4, FUT2, Gγ4, GCS-α-1, GDE4, GLDC, GLOD5, GlyR α2, Gm14137, GPR141, GPRC5B, GRAMD1B, GRAMD1C, GS2, HACL1, HDHD3, HIBADH, Histamine, Histone H2A.Bbd, HM74A, HM74B, HRASLS, I-TAC, IDAS, IL-23R, IL-9R, IQSEC2, ISLR2, ITBA1, JMJD1C, Josephin-2, KIAA1024_AF529169, KRTAP20-2, KRTAP26-1, KRTAP3-2, KRTAP3-3, Krtap31-2, KRTAP6-3, KRTAP9-2, LAL, LAPTM4B, LAPTM5, LASS4, LCAT, LDL, LDLRAD4, LIGHT, Lmf1, Lmf2, LOC730005, LPD lipase, LPL, LPPR3, LR8, LRRC55, lysine, MC4-R, MCAD, mHMGCS, Monoglyceride Lipase, MRP-L44, mSHMT, Msx-1, Mycobacterium avium, NADSYN1, NAPRT, NAT-5, NDUFA8, NDUFS8, Neutrophil Marker, NHLRC3, NMNAT-1, NMNAT-3, NNMT, nucleobindin, NYD-SP17, Oatp5, OCTL1, ORP-6, Ox-LDL R-1, P76, PAP-2c, PARP S, PARP-1, PARP-10, PARP-6, PC-PLD5, PC-TP, PC7/8, PED7A, PEPD, PHKA2, PI 4-kinase II β, PITP, PLBD1, PLC ε, PLTP, PNMA6A, PNPLA1, PPAPDC3, PRRT1B, PTP-PEST, QAPRTase, QDPR, Rad54, RBKS, RBM14, Ricin B, RNase H1, RPA135, S-100Z, SA-1, Sc5d, SCD2, SCP2D1, SDHA, SDR16C6, SF-1, SLC17A2, SmcY, SMIT, Sodium Taurochenodeoxycholate, SP-A2, SR-B1, SREC, StARD6, Synaptotagmin XVII, TBL2, TKTL1, TMEM185A, TMEM200C, TMEM229B, TPCN2, TPH, TRAP240, Treacle, UCP3, VAP-B/C, Vmn1r12, Vmn1r175, Vmn2r2, VPS13A, VPS4B, WDR92, ZAG, and ZNF202.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nicotinic Acid, 250 g | sc-205768 | 250 g | $61.00 | |||
Nicotinic Acid, 500 g | sc-205768A | 500 g | $122.00 |