Molecular structure of Cilostazol, CAS Number: 73963-72-1
Cilostazol (CAS 73963-72-1)
See product citations (3)
Alternate Names:
6-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)-butoxy]-3,4-dihydro-2(1H)-quinolinone; Pletal; Cilostazolum
Application:
Cilostazol is a PDE inhibitor, antimitogenic, antithrombotic, and cardiotonic agent
CAS Number:
73963-72-1
Purity:
98%
Molecular Weight:
369.5
Molecular Formula:
C20H27N5O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Cilostazol is extensively utilized in research focused on its role as a phosphodiesterase III inhibitor. This compound is particularly valuable in studies examining its effects on cyclic AMP accumulation within cells, which is relevant for understanding cellular signaling pathways. Researchers use Cilostazol to investigate its influence on platelet aggregation and vasodilation in various experimental models. Additionally, it is employed in studies looking at lipid metabolism and its effects on smooth muscle cell proliferation. Through these research applications, Cilostazol contributes to a broader understanding of cellular responses to cyclic nucleotide modulation and its effects on vascular health.
Cilostazol (CAS 73963-72-1) References
- The pharmacology of cilostazol. | Schrör, K. 2002. Diabetes Obes Metab. 4 Suppl 2: S14-9. PMID: 12180353
- Cilostazol as a unique antithrombotic agent. | Kambayashi, J., et al. 2003. Curr Pharm Des. 9: 2289-302. PMID: 14529391
- Cilostazol prevents focal cerebral ischemic injury by enhancing casein kinase 2 phosphorylation and suppression of phosphatase and tensin homolog deleted from chromosome 10 phosphorylation in rats. | Lee, JH., et al. 2004. J Pharmacol Exp Ther. 308: 896-903. PMID: 14634032
- Protective effects of cilostazol against transient focal cerebral ischemia and chronic cerebral hypoperfusion injury. | Lee, JH., et al. 2008. CNS Neurosci Ther. 14: 143-52. PMID: 18482026
- Cilostazol suppresses angiotensin II-induced apoptosis in endothelial cells. | Shi, MQ., et al. 2016. Mol Med Rep. 13: 2597-605. PMID: 26862035
- Cilostazol protects hepatocytes against alcohol-induced apoptosis via activation of AMPK pathway. | Lee, YJ., et al. 2019. PLoS One. 14: e0211415. PMID: 30695051
- Cilostazol preconditioning alleviates cyclophosphamide-induced cardiotoxicity in male rats: Mechanistic insights into SIRT1 signaling pathway. | Elrashidy, RA. and Hasan, RA. 2021. Life Sci. 266: 118822. PMID: 33275987
- Cilostazol-mediated reversion of γ-globin silencing is associated with a high level of HbF production: A potential therapeutic candidate for β-globin disorders. | Ali, H., et al. 2021. Biomed Pharmacother. 142: 112058. PMID: 34426256
- Inhibition of Phosphodiesterase 3A by Cilostazol Dampens Proinflammatory Platelet Functions. | Coenen, DM., et al. 2021. Cells. 10: PMID: 34440764
- Cilostazol Induces eNOS and TM Expression via Activation with Sirtuin 1/Krüppel-like Factor 2 Pathway in Endothelial Cells. | Wu, CH., et al. 2021. Int J Mol Sci. 22: PMID: 34638626
- Cilostazol attenuates cardiac oxidative stress and inflammation in hypercholesterolemic rats. | de Oliveira Lopes, R., et al. 2022. Naunyn Schmiedebergs Arch Pharmacol. 395: 789-801. PMID: 35384464
- Cilostazol Attenuates AngII-Induced Cardiac Fibrosis in apoE Deficient Mice. | Hada, Y., et al. 2022. Int J Mol Sci. 23: PMID: 36012328
- Effects of Cilostazol on Angiogenesis in Diabetes through Adiponectin/Adiponectin Receptors/Sirtuin1 Signaling Pathway. | Tseng, SY., et al. 2022. Int J Mol Sci. 23: PMID: 36499166
Inhibitor of:
ABCC12, Ataxin-3, C22orf13, CD42b, EG624219, GPVI, IPP-2, MRAP, MYPT3, Olfr107, Olfr44, Olfr64, Olfr701, Olfr702, Olfr748, Olfr749, Olr1472, Olr401, Olr409, PDE 3A, PDE1B, PDE3A, PDE3B, PDE6Aα, PDE6G, PDE6H, PDE8B, PECAM-1, PED7A, PEDF, PLB, PNUTS, PP2A-Aβ, RD3L, SR-A, TREML1, and VWF.Activator of:
ε-sarcoglycan, 1190002N15Rik, 2610044O15Rik, ABCE1, ABHD3, ACSF2, ADCK5, AI467606, AKAP 13, AKAP 9, ARA160, ARHGEF3, ARMCX1, ARRDC1, BC028528, C20orf135, C20orf152, CCDC41, CCDC94, CCK-AR, CD97, Cdc5L, CdcA7, cGKII, Chromozym t-PA, claudin-5, CLCA5_Clac5, CNBD1, CNG-2, CNG-3, CNPase, CPA6, CPXM, CREST, CRISP-2, CTRP5, CXorf56, Cypt12, dHAND, DPCD, EPCR, FBXO44, GCAP2, GCC1, Giantin, GNPTAB, GPR179, GPR22, GPR61, GPR63, GSBS, GUCD1, Gucy2g, HCN1, HSPC144, IGSF1, IGTP, IPPK, KCNE1L, KCNH6, KCNH7, KCNMB4, KIF18B, KILLIN, KIR2.1, KVβ.1, LAGE-3, LAL, LLPH, LOC255809_AB124611, Ly6g, MACROD2, MANSC1, MBD3L5, MLK4, MYBPC1, MYH15, MYL2, myomegalin, Na+ CP type Xα, NDRG3, NF-M, NMUR2, NT5C1B, NTCP, OAT5, Odf1, OLFM1, Olfr868, Olfr869, OR5I1, ORP-5, Otospiralin, Oviductin, PAAF1, PCDHA13, PCTAIRE-3, PDE 3A, PDE4C, PDE6α, PDE9A, Peg1, PGI2 synthase, PHT2, PIPPIN, PIR1, PKR2, Platelet IIb, protein phosphatase (PPP3R1 PPP3R2), PSD-95, RBFA, RENBP, Rfp2, RGS1, Rim2, RN-tre, Rpp25, RSP3, Sarcalumenin, SerpinA9, SPDYE2L, SSTR5, StARD8, Synaptopodin, Synaptoporin, Syntaxin 1, t-GMP, taperin, Telethonin, TFG, TFIIIC220, THEG, TMEM150B, TMEM216, TMEM218, TMEM233, Torsin2A, TTLL13, UPase, VASP, Vinexin, Vmn1r77, WBSCR17, WBSCR28, WDR19, WDR46, WDR73, WECHE, YPEL4, ZBTB42, and ZDHHC1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cilostazol, 10 mg | sc-201182 | 10 mg | $107.00 | |||
Cilostazol, 50 mg | sc-201182A | 50 mg | $316.00 |