KRTAP5-8 Inhibitors
KRTAP5-8 Inhibitors are conceptualized based on the premise that compounds which affect hair follicle biology and keratinization can indirectly inhibit the function of KRTAP5-8. Retinoic Acid, for instance, is known to modulate gene expression related to keratins and keratin-associated proteins, which are integral to hair shaft formation. By inducing hair follicle regression, retinoic acid would negate the functional necessity for KRTAP5-8 in hair structure. Similarly, Eflornithine's mechanism of action through the inhibition of ornithine decarboxylase impedes polyamine synthesis necessary for rapid cell division and proliferation that occurs during hair growth. This action can lead to a reduced structural demand for KRTAP5-8 during hair formation, effectively decreasing its functional activity within the hair follicle.
Compounds like Finasteride and Dutasteride operate by inhibiting 5-alpha-reductase, thus diminishing androgen activity, which is crucial for hair growth regulation. With altered hair growth patterns, the expression and, consequently, the structural incorporation of KRTAP5Given that KRTAP5-8 is a member of the keratin-associated protein (KAP) family involved in hair formation, finding direct chemical inhibitors is not straightforward since these proteins are structural and do not have enzymatic activity that can be inhibited in the classical sense.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid affects keratin gene expression and can lead to hair follicle regression (catagen). As KRTAP5-8 is involved in hair formation, retinoic acid-induced follicle regression would decrease KRTAP5-8's functional role. | ||||||
Minoxidil (U-10858) | 38304-91-5 | sc-200984 sc-200984A | 100 mg 1 g | $68.00 $344.00 | ||
Minoxidil extends the anagen phase of hair follicles, but overuse can cause a paradoxical telogen effluvium. This shedding phase would reduce the need for KRTAP5-8's role in hair structure. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporine A inadvertently promotes hair growth, but its modulation of immune response can alter follicular dynamics, potentially affecting KRTAP5-8's incorporation into hair. | ||||||
Difluoromethylornithine | 70052-12-9 | sc-204723 sc-204723A sc-204723B sc-204723C sc-204723D sc-204723E | 10 mg 25 mg 100 mg 250 mg 1 g 5 g | $58.00 $130.00 $158.00 $311.00 $964.00 $4726.00 | 2 | |
Eflornithine inhibits ornithine decarboxylase, which is essential for cell division and hair growth. This inhibition could reduce the structural demand for KRTAP5-8. | ||||||
Finasteride | 98319-26-7 | sc-203954 | 50 mg | $103.00 | 3 | |
Finasteride inhibits 5-alpha-reductase, affecting androgen activity and hair growth patterns, which could indirectly decrease KRTAP5-8's role in hair shaft formation. | ||||||
Spironolactone | 52-01-7 | sc-204294 | 50 mg | $107.00 | 3 | |
Spironolactone acts as an androgen blocker and can alter hair growth. These alterations may decrease the incorporation of KRTAP5-8 into hair structures. | ||||||
Bimatoprost | 155206-00-1 | sc-205224 sc-205224A | 1 mg 5 mg | $118.00 $455.00 | 1 | |
Bimatoprost prolongs the anagen phase of the hair cycle. The disruption of normal hair cycling can indirectly influence KRTAP5-8 expression and function. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine can stimulate hair follicle growth by targeting DHT in the scalp. It may alter the hair cycle, impacting the role of KRTAP5-8 in hair formation. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $62.00 $260.00 | 21 | |
Ketoconazole is an antifungal that can disrupt fungal infections on the scalp, potentially affecting the hair microenvironment and the role of KRTAP5-8 in hair formation. | ||||||
Dutasteride | 164656-23-9 | sc-207600 | 10 mg | $167.00 | 2 | |
Dutasteride inhibits both type I and type II 5-alpha-reductase, affecting dihydrotestosterone levels and hair cycling, possibly influencing KRTAP5-8 activity. | ||||||