Date published: 2026-2-4

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Bimatoprost (CAS 155206-00-1)

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Alternate Names:
Lumigan
Application:
Bimatoprost is the precursor to a potent PGFR agonist
CAS Number:
155206-00-1
Purity:
≥94%
Molecular Weight:
415.57
Molecular Formula:
C25H37NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Bimatoprost is a prostaglandin analog that functions as a prostamide. It acts as a potent agonist at the prostaglandin FP receptor, leading to increased outflow of aqueous humor from the eye. Bimatoprost′s mechanism of action involves binding to the prostaglandin FP receptor, which is present in the ciliary muscle of the eye. By activating this receptor, bimatoprost facilitates the drainage of aqueous humor, thereby reducing intraocular pressure. Bimatoprost may increase the length and thickness of eyelashes, although the exact mechanism behind this effect is not fully understood. At the molecular level, bimatoprost′s interaction with the prostaglandin FP receptor leads to downstream signaling events that ultimately result in the desired physiological responses. Bimatoprost′s function and mechanism of action make it for investigating the regulation of intraocular pressure and potential effects on eyelash growth in experimental applications.


Bimatoprost (CAS 155206-00-1) References

  1. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs.  |  Abramovitz, M., et al. 2000. Biochim Biophys Acta. 1483: 285-93. PMID: 10634944
  2. The pharmacology of bimatoprost (Lumigan).  |  Woodward, DF., et al. 2001. Surv Ophthalmol. 45 Suppl 4: S337-45. PMID: 11434936
  3. The hydrolysis of bimatoprost in corneal tissue generates a potent prostanoid FP receptor agonist.  |  Maxey, KM., et al. 2002. Surv Ophthalmol. 47 Suppl 1: S34-40. PMID: 12204699
  4. Human trabecular meshwork cell responses induced by bimatoprost, travoprost, unoprostone, and other FP prostaglandin receptor agonist analogues.  |  Sharif, NA., et al. 2003. Invest Ophthalmol Vis Sci. 44: 715-21. PMID: 12556403
  5. In vitro study of inflammatory potential and toxicity profile of latanoprost, travoprost, and bimatoprost in conjunctiva-derived epithelial cells.  |  Guenoun, JM., et al. 2005. Invest Ophthalmol Vis Sci. 46: 2444-50. PMID: 15980234
  6. Effect of bimatoprost on intraocular pressure in prostaglandin FP receptor knockout mice.  |  Crowston, JG., et al. 2005. Invest Ophthalmol Vis Sci. 46: 4571-7. PMID: 16303950
  7. In vitro comparison of cytoprotective and antioxidative effects of latanoprost, travoprost, and bimatoprost on conjunctiva-derived epithelial cells.  |  Guenoun, JM., et al. 2005. Invest Ophthalmol Vis Sci. 46: 4594-9. PMID: 16303954
  8. Structural requirements for prostaglandin analog interaction with the ovine corpus luteum prostaglandin F2 alpha receptor. Implications for development of a photoaffinity probe.  |  Balapure, AK., et al. 1989. Biochem Pharmacol. 38: 2375-81. PMID: 2751699
  9. Impact of prostaglandin glaucoma drops on platelet-activating factor action: an in vitro study.  |  Moschos, MM., et al. 2016. Drug Des Devel Ther. 10: 3977-3981. PMID: 27994439
  10. Bimatoprost sustained-release intracameral implant reduces episcleral venous pressure in dogs.  |  Lee, SS., et al. 2018. Vet Ophthalmol. 21: 376-381. PMID: 29457333
  11. Intracameral Sustained-Release Bimatoprost Implant Delivers Bimatoprost to Target Tissues with Reduced Drug Exposure to Off-Target Tissues.  |  Seal, JR., et al. 2019. J Ocul Pharmacol Ther. 35: 50-57. PMID: 30335560
  12. Effect of Topical Prostaglandin F2α Analogs on Selected Oxidative Stress Parameters in the Tear Film.  |  Sedlak, L., et al. 2019. Medicina (Kaunas). 55: PMID: 31336766
  13. Cloning of the rat and human prostaglandin F2 alpha receptors and the expression of the rat prostaglandin F2 alpha receptor.  |  Lake, S., et al. 1994. FEBS Lett. 355: 317-25. PMID: 7988697

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Bimatoprost, 1 mg

sc-205224
1 mg
$120.00

Bimatoprost, 5 mg

sc-205224A
5 mg
$464.00

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. Bimatoprost, sc-205224, is in white to almost white powder form.
Answered by: Chemical Support 4
Date published: 2021-09-18
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Rated 5 out of 5 by from Maxey et alMaxey et al. (PubMed ID 12204699) found that Bimatoprost hydrolysis within human and bovine corneal tissue resulted in the generation of a strong prostanoid FP receptor agonist. -SCBT Publication Review
Date published: 2015-04-27
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Bimatoprost is rated 5.0 out of 5 by 1.
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