Molecular structure of Finasteride, CAS Number: 98319-26-7
Finasteride (CAS 98319-26-7)
See product citations (3)
Alternate Names:
MK 906
Application:
Finasteride is an antiandrogen that inhibits 5α-Reductase 2
CAS Number:
98319-26-7
Molecular Weight:
372.55
Molecular Formula:
C23H36N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Finasteride is a synthetic 4-azasteroid antiandrogen compound. This specifically inhibits 5alpha-Reductase 2, an intracellular enzyme that converts the androgen testosterone into 5alpha dihydrotestosterone (DHT). Finasteride inhibits 5alpha-reductase activity in epithelium for Ki of 10nM, significantly lower than in stroma (Ki = 33nM). Finasteride is an inhibitor of 5alpha-Reductase 1.
Finasteride (CAS 98319-26-7) References
- Four-amino acid segment in steroid 5 alpha-reductase 1 confers sensitivity to finasteride, a competitive inhibitor. | Thigpen, AE. and Russell, DW. 1992. J Biol Chem. 267: 8577-83. PMID: 1314830
- Comparison of the pharmacological effects of a novel selective androgen receptor modulator, the 5alpha-reductase inhibitor finasteride, and the antiandrogen hydroxyflutamide in intact rats: new approach for benign prostate hyperplasia. | Gao, W., et al. 2004. Endocrinology. 145: 5420-8. PMID: 15308613
- Studies on neurosteroids XXV. Influence of a 5alpha-reductase inhibitor, finasteride, on rat brain neurosteroid levels and metabolism. | Mukai, Y., et al. 2008. Biol Pharm Bull. 31: 1646-50. PMID: 18758053
- Finasteride inhibited brain dopaminergic system and open-field behaviors in adolescent male rats. | Li, L., et al. 2018. CNS Neurosci Ther. 24: 115-125. PMID: 29214729
- Finasteride inhibits melanogenesis through regulation of the adenylate cyclase in melanocytes and melanoma cells. | Seo, JO., et al. 2018. Arch Pharm Res. 41: 324-332. PMID: 29397551
- Repeated finasteride administration induces depression-like behavior in adult male rats. | Sasibhushana, RB., et al. 2019. Behav Brain Res. 365: 185-189. PMID: 30836157
- Development of finasteride polymer microspheres for systemic application in androgenic alopecia. | Kim, JH., et al. 2019. Int J Mol Med. 43: 2409-2419. PMID: 30942390
- Finasteride-Induced Inhibition of 5α-Reductase Type 2 Could Lead to Kidney Damage-Animal, Experimental Study. | Baig, MS., et al. 2019. Int J Environ Res Public Health. 16: PMID: 31100850
- Protective effects of finasteride against testosterone-induced calcium oxalate crystallization and crystal-cell adhesion. | Sueksakit, K. and Thongboonkerd, V. 2019. J Biol Inorg Chem. 24: 973-983. PMID: 31342142
- The effect of finasteride and dutasteride on the synthesis of neurosteroids by glioblastoma cells. | Pinacho-Garcia, LM., et al. 2020. Steroids. 155: 108556. PMID: 31866547
- Paternal Finasteride Treatment Can Influence the Testicular Transcriptome Profile of Male Offspring-Preliminary Study. | Kolasa, A., et al. 2021. Curr Issues Mol Biol. 43: 868-886. PMID: 34449557
- Does treatment with dutasteride or finasteride has impact on renal morphology? Experimental study. | Silva, MHAD., et al. 2021. Acta Cir Bras. 36: e360703. PMID: 34550196
- Gut Inflammation Induced by Finasteride Withdrawal: Therapeutic Effect of Allopregnanolone in Adult Male Rats. | Diviccaro, S., et al. 2022. Biomolecules. 12: PMID: 36358917
Inhibitor of:
17β-HSD, 17β-HSD11, 17β-HSD14, 17β-HSD2, 17β-HSD6, 17β-HSD7, 2610019F03Rik, 3β-HSD7, 5 alpha-Reductase 1, 5 alpha-Reductase 2, Abp ε, AKR1D1, BOULE, C6orf10, Choriogonadotropin, Choriogonadotropin β, CSH1, DHRS7, EG384585, EG434676, EG545948, EG623898, EG639025, EG665615, EG667693, Eppin, Estradiol, Etd, GnRH-associated peptide, Gonadotropin α, Gonadotropin β, HCG3, HoxC13, INSL3, Kap, KRTAP1-1, KRTAP1-3, KRTAP10-9, KRTAP16-1, KRTAP17-1, KRTAP2, KRTAP20-1, KRTAP3-1, KRTAP4, KRTAP4-1, KRTAP4-12, KRTAP4-3, KRTAP4-6, KRTAP5-8, KRTAP6-2, KRTAP8-1, LOC647264, MBPH, MEA-1, MISR II, mPRγ, MUP1, MUP11, NK-3R, Olr1591, Olr192, OTTMUSG00000008394, Oviductin, PELO, probasin, PSA, PSGR, Purγ, SDR39U1, SHBG, SLY, SMR2, SMR3A, SPATA25, SPEER-2, SR-5A, SRD5A2L, SRD5A2L2, TCP-11, Testosterone, TEX30, TSARG1, Tsx, and Vmn2r23.Activator of:
AKR1C18, Androgen Receptor, DD3, Gonadotropin β, HR, Keratin 33B, KLK2, KLK4, KRTAP10, KRTAP10-10, KRTAP10-11, KRTAP10-8, KRTAP22-1, KRTAP4-11, KRTAP4-3, KRTAP4-5, KRTAP4-8, KRTAP5, KRTAP5-5, KRTAP9-3, KRTAP9-4, KRTAP9-9, KRTAP9-L3, MUP6, PAP-γ, RBMY1J, Semenogelin-2, SPANX-B, SRD5A2L, and TCHHL1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Finasteride, 50 mg | sc-203954 | 50 mg | $103.00 |