Difluoromethylornithine (CAS 70052-12-9)
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Difluoromethylornithine (DFMO) is a potent, irreversible inhibitor of ornithine decarboxylase (ODC), the enzyme responsible for the rate-limiting step in polyamine biosynthesis. Polyamines, such as putrescine, spermidine, and spermine, are critical for cell growth and differentiation. By inhibiting ODC, Difluoromethylornithine effectively reduces the intracellular concentrations of these polyamines. This mechanism of action has made Difluoromethylornithine useful in research, particularly in the study of cellular processes such as proliferation, differentiation, and apoptosis. Furthermore, its ability to modulate polyamine metabolism has led to its utilization in exploring the pathways involved in cellular regulation and the potential to disrupt those pathways in various models of disease. Difluoromethylornithine′s unique biochemical properties and its impact on critical cellular functions underscore its importance in scientific investigations aimed at understanding the intricate balance of cellular growth and regulation.
Difluoromethylornithine (CAS 70052-12-9) References
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Difluoromethylornithine, 10 mg | sc-204723 | 10 mg | $58.00 | |||
Difluoromethylornithine, 25 mg | sc-204723A | 25 mg | $130.00 | |||
Difluoromethylornithine, 100 mg | sc-204723B | 100 mg | $158.00 | |||
Difluoromethylornithine, 250 mg | sc-204723C | 250 mg | $311.00 | |||
Difluoromethylornithine, 1 g | sc-204723D | 1 g | $964.00 | |||
Difluoromethylornithine, 5 g | sc-204723E | 5 g | $4726.00 |