Molecular structure of Minoxidil (U-10858), CAS Number: 38304-91-5
Minoxidil (U-10858) (CAS 38304-91-5)
Alternate Names:
6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide; 6-(1-Piperidinyl)pyrimidine-2,4-diamine 3-oxide; 2,4-Diamino-6-piperidinopyrimidine 3-N-oxide
Application:
Minoxidil (U-10858) is a selective ATP dependent K+ (Kir6) channel activator
CAS Number:
38304-91-5
Molecular Weight:
209.3
Molecular Formula:
C9H15N5O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Minoxidil (U-10858) is a selective ATP dependent K+ channel (Kir6) activator. As a result membrane permeability increases the flow of K+ across the membrane, which turns off voltage gated calcium channels. This inhibition in action potential causes a relaxation in arteriolar smooth muscle. Alternate studies indicate that Minoxidil (U-10858) activates the beta-catenin pathway in human dermal papilla cells which results in accumulation of beta-catenin in the nucleus.
Minoxidil (U-10858) (CAS 38304-91-5) References
- The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial. | Berger, RS., et al. 2003. Br J Dermatol. 149: 354-62. PMID: 12932243
- Minoxidil specifically decreases the expression of lysine hydroxylase in cultured human skin fibroblasts. | Hautala, T., et al. 1992. Biochem J. 283 (Pt 1): 51-4. PMID: 1314568
- Evaluation of blood flow parameters in addition to blood pressure and electrocardiogram in the conscious telemetered beagle dog. | Taylor, GL., et al. 2007. J Pharmacol Toxicol Methods. 56: 212-7. PMID: 17582788
- Minoxidil activates β-catenin pathway in human dermal papilla cells: a possible explanation for its anagen prolongation effect. | Kwack, MH., et al. 2011. J Dermatol Sci. 62: 154-9. PMID: 21524889
- The promoting effect of Ishige sinicola on hair growth. | Kang, JI., et al. 2013. Mar Drugs. 11: 1783-99. PMID: 23708185
- The ginsenosides of Panax ginseng promote hair growth via similar mechanism of minoxidil. | Kim, SN., et al. 2015. J Dermatol Sci. 77: 132-4. PMID: 25617238
- Hot water extract of oriental melon leaf promotes hair growth and prolongs anagen hair cycle: In vivo and in vitro evaluation. | Pi, LQ., et al. 2016. Food Sci Biotechnol. 25: 575-580. PMID: 30263308
- Lysyl Hydroxylase Inhibition by Minoxidil Blocks Collagen Deposition and Prevents Pulmonary Fibrosis via TGF-β₁/Smad3 Signaling Pathway. | Shao, S., et al. 2018. Med Sci Monit. 24: 8592-8601. PMID: 30481795
- Norgalanthamine Stimulates Proliferation of Dermal Papilla Cells via Anagen-Activating Signaling Pathways. | Yoon, HS., et al. 2019. Biol Pharm Bull. 42: 139-143. PMID: 30606985
- Mechanism of action of minoxidil sulfate-induced vasodilation: a role for increased K+ permeability. | Meisheri, KD., et al. 1988. J Pharmacol Exp Ther. 245: 751-60. PMID: 3385640
- Minoxidil: a review of its pharmacological properties and therapeutic use. | Campese, VM. 1981. Drugs. 22: 257-78. PMID: 7030707
- Possible presence of the ATP-sensitive K+ channel in isolated spinal dorsal horn neurons of the rat. | Yamashita, S., et al. 1994. Neurosci Lett. 170: 208-12. PMID: 8058189
- The effect of minoxidil on keratocyte proliferation in cell culture. | McLeod, SD., et al. 1998. Ophthalmic Res. 30: 263-70. PMID: 9667057
Inhibitor of:
17β-HSD7, HoxC13, KCNRG, KRTAP1-1, KRTAP1-3, KRTAP1-5, KRTAP10-9, KRTAP17-1, KRTAP2, KRTAP2-4, KRTAP3-1, KRTAP4, KRTAP4-12, KRTAP4-3, KRTAP4-6, KRTAP5-8, LOC647264, Olr24, Olr434, and PELO.Activator of:
CDT6, COL6A6, elastin, FRAS1, GK3P, HR, IFN-α4, Keratin 25, Keratin 26, Keratin 32, Keratin 33A, Keratin 33B, Keratin 35, Keratin 36, Keratin 38, Keratin 6B, Keratin 72, Keratin 75, Keratin 79, Keratin 86, KIR, KIR6.1, KIR6.2, KRT222P, KRTAP1, KRTAP1-1, KRTAP1-3, KRTAP1-5, KRTAP10, KRTAP10-10, KRTAP10-11, KRTAP10-2, KRTAP10-5, KRTAP10-6, KRTAP10-8, KRTAP10-9, KRTAP11-1, KRTAP12-3, KRTAP12-4, KRTAP13, KRTAP13-3, KRTAP14, KRTAP15-1, KRTAP16-1, KRTAP16-4, KRTAP16-8, KRTAP17-1, KRTAP19-1, KRTAP19-2, KRTAP19-5, KRTAP19-7, KRTAP2-1, KRTAP2-3, KRTAP20-1, KRTAP20-2, KRTAP21-1, KRTAP21-2, KRTAP22-1, KRTAP22-2, KRTAP23-1, KRTAP26-1, KRTAP3-1, KRTAP3-2, KRTAP3-3, KRTAP4, KRTAP4-1, KRTAP4-11, KRTAP4-13, Krtap4-16, KRTAP4-3, KRTAP4-4, KRTAP4-5, KRTAP4-8, KRTAP5, KRTAP5-11, KRTAP5-2, KRTAP5-3, KRTAP5-5, KRTAP5-6, KRTAP5-8, KRTAP6-2, KRTAP6-3, KRTAP7-1, KRTAP8-1, KRTAP9, KRTAP9-3, KRTAP9-4, KRTAP9-9, KRTAP9-L3, KVβ.1, LCA5, LLPH, LOC647264, MYH15, myocilin, PCPE-1, Potassium Chloride, SULT1A1, TASK-2, and TCHHL1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Minoxidil (U-10858), 100 mg | sc-200984 | 100 mg | $68.00 | |||
Minoxidil (U-10858), 1 g | sc-200984A | 1 g | $344.00 |