Molecular structure of Dutasteride, CAS Number: 164656-23-9
Dutasteride (CAS 164656-23-9)
See product citations (2)
Alternate Names:
(4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-[2,5-Bis(trifluoromethyl)phenyl]-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-dimethyl-2-oxo-1H-Indeno[5,4-f]quinoline-7-carboxamide; (5α,17β)-N-[2,5-Bis(trifluoromethyl)phenyl]-3-oxo-4-azaandrost-1-ene-17-carboxamide; Avodart; Avolve; GG 745; GI 198745; Veltride
Application:
Dutasteride is a dual inhibitor of 5α-reductase isoenzymes type 1 and 2
CAS Number:
164656-23-9
Purity:
≥99%
Molecular Weight:
528.53
Molecular Formula:
C27H30F6N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Dutasteride is a 5-alpha-reductase inhibitor that inhibits the conversion of testosterone into dihydrotestosterone (DHT). Dutasteride inhibits both isoforms of 5-alpha reductase (5 alpha-Reductase 1/5aR1 and 5 alpha-Reductase 2/5aR2) to a similar extent (IC50 6nmol/l and 7 nmol/l, respectively), while finasteride only inhibits Type II. Dutasteride competes for binding to the LNCaP cell AR with an IC50 value of approximately 1.5 muM. The compound has been used to study the effects of 5-alpha-reductase inhibition on the binding and metabolism of testosterone and other steroids to androgen receptors, as well as its impact on the expression of genes involved in prostate growth and development.
Dutasteride (CAS 164656-23-9) References
- The pharmacokinetic modelling of GI198745 (dutasteride), a compound with parallel linear and nonlinear elimination. | Gisleskog, PO., et al. 1999. Br J Clin Pharmacol. 47: 53-8. PMID: 10073740
- Dutasteride, the dual 5alpha-reductase inhibitor, inhibits androgen action and promotes cell death in the LNCaP prostate cancer cell line. | Lazier, CB., et al. 2004. Prostate. 58: 130-44. PMID: 14716738
- Dutasteride: a novel dual inhibitor of 5alpha-reductase for benign prostatic hyperplasia. | Djavan, B., et al. 2005. Expert Opin Pharmacother. 6: 311-7. PMID: 15757426
- Effect of the 5α-reductase enzyme inhibitor dutasteride in the brain of intact and parkinsonian mice. | Litim, N., et al. 2017. J Steroid Biochem Mol Biol. 174: 242-256. PMID: 28982631
- The effect of dutasteride on microscopic and macroscopic changes of testosterone replacement treatment on prostate tissue. | Diri, MA., et al. 2018. Andrologia. 50: e13110. PMID: 30024036
- Pharmacokinetic Study of a Soft Gelatin Capsule and a Solid-Supersaturatable SMEDDS Tablet of Dutasteride in Beagle Dogs. | Kim, JS., et al. 2020. Eur J Drug Metab Pharmacokinet. 45: 235-241. PMID: 31782125
- Impact of dutasteride on spermatogenesis and oxidative status in rats. | Gul, A., et al. 2020. Arch Esp Urol. 73: 230-235. PMID: 32240114
- Effects of dutasteride in a rat model of chemically induced prostatic inflammation-Potential role of estrogen receptor β. | Mizoguchi, S., et al. 2020. Prostate. 80: 1413-1420. PMID: 32941694
- Dutasteride combined with androgen receptor antagonists inhibit glioblastoma U87 cell metabolism, proliferation, and invasion capacity: Androgen regulation. | Orozco, M., et al. 2020. Steroids. 164: 108733. PMID: 32980365
- Effects of Curcumin Combined With the 5-alpha Reductase Inhibitor Dutasteride on LNCaP Prostate Cancer Cells. | Nakayama, A., et al. 2021. In Vivo. 35: 1443-1450. PMID: 33910821
- Impact of short-term Dutasteride treatment on prostate-specific membrane antigen expression in a mouse xenograft model. | Kranzbühler, B., et al. 2021. Cancer Rep (Hoboken). 4: e1418. PMID: 34008909
- Ameliorative effect of morin on dutasteride-tamsulosin-induced testicular oxidative stress in rat. | Olayinka, ET. and Adewole, KE. 2020. J Complement Integr Med. 18: 327-337. PMID: 34187124
- 4-Aza-3-oxo-5 alpha-androst-1-ene-17 beta-N-aryl-carboxamides as dual inhibitors of human type 1 and type 2 steroid 5 alpha-reductases. Dramatic effect of N-aryl substituents on type 1 and type 2 5 alpha-reductase inhibitory potency. | Bakshi, RK., et al. 1995. J Med Chem. 38: 3189-92. PMID: 7650670
Inhibitor of:
17β-HSD, 17β-HSD11, 17β-HSD14, 17β-HSD2, 17β-HSD6, 17β-HSD7, 5 alpha-Reductase 1, 5 alpha-Reductase 2, Abp ε, AKR1D1, BOULE, Choriogonadotropin β, DHRS7, EG384585, EG623898, EG639025, EG665615, EG667693, Estradiol, GnRH-associated peptide, Gonadotropin β, HCG3, Kap, KRTAP10-2, KRTAP20-1, KRTAP5-8, MBPH, MEA-1, MISR II, OTTMUSG00000008394, PELO, probasin, PSA, PSGR, Purγ, SMR2, SMR3A, SPEER-2, SR-5A, SRD5A2L, SRD5A2L2, TCP-11, Testosterone, TEX30, Tsx, and Vmn2r23.Activator of:
AKR1C18, Androgen Receptor, DD3, Gonadotropin β, and Semenogelin-2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dutasteride, 10 mg | sc-207600 | 10 mg | $167.00 |