Dutasteride is a 5-α-reductase inhibitor that inhibits the conversion of testosterone into dihydrotestosterone (DHT). Dutasteride inhibits both isoforms of 5-α reductase (5 α-Reductase 1/5aR1 and 5 α-Reductase 2/5aR2) to a similar extent (IC50 6nmol/l and 7 nmol/l, respectively), while finasteride only inhibits Type II. Dutasteride competed for binding the LNCaP cell AR with an IC50 approximately 1.5 μM.
Bakshi, R.K., et al.: J. Med. Chem., 38, 3189 (1995), Gisleskog, P.O., et al.: Brit. J. Clin. Pharmacol., 47, 53 (1999), Djavan, B., et al.: Expert Opin. Pharmacother., 6, 311 (2005),
Soluble in ethanol (44 mg/ml), methanol (64 mg/ml), polyethylene glycol 400 (3 mg/ml), and DMSO (62 mg/ml at 25° C 117mM). Insoluble in water.
Store at 4° C
~620.3° C at 760 mmHg (Predicted)
~1.3 g/cm3 (Predicted)
n20D 1.52 (Predicted)
3 β-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase: IC50 >0.15 mM (Mycobacterium tuberculosis)
pKa: 13.32 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Rated 5 out of
Alonso et alAlonso et al. (PubMed ID 26345405) used Dutasteride to inhibit 5 alpha-reductase to increase immunoreactivities in estrogen-receptor beta as well as the androgen receptor. -SCBT Publication Review
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