Dutasteride CAS: 164656-23-9
MF: C27H30F6N2O2
MW: 528.53
A dual inhibitor of 5α-reductase isoenzymes type 1 and 2.

Dutasteride (CAS 164656-23-9)

Dutasteride | CAS 164656-23-9 is rated 5.0 out of 5 by 1.
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Alternate Names: (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-[2,5-Bis(trifluoromethyl)phenyl]-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-dimethyl-2-oxo-1H-Indeno[5,4-f]quinoline-7-carboxamide; (5α,17β)-N-[2,5-Bis(trifluoromethyl)phenyl]-3-oxo-4-azaandrost-1-ene-17-carboxamide; Avodart; Avolve; GG 745; GI 198745; Veltride
Application: Dutasteride is a dual inhibitor of 5α-reductase isoenzymes type 1 and 2
CAS Number: 164656-23-9
Purity: ≥99%
Molecular Weight: 528.53
Molecular Formula: C27H30F6N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Dutasteride is a 5-α-reductase inhibitor that inhibits the conversion of testosterone into dihydrotestosterone (DHT). Dutasteride inhibits both isoforms of 5-α reductase (5 α-Reductase 1/5aR1 and 5 α-Reductase 2/5aR2) to a similar extent (IC50 6nmol/l and 7 nmol/l, respectively), while finasteride only inhibits Type II. Dutasteride competed for binding the LNCaP cell AR with an IC50 approximately 1.5 μM.


References

Bakshi, R.K., et al.: J. Med. Chem., 38, 3189 (1995), Gisleskog, P.O., et al.: Brit. J. Clin. Pharmacol., 47, 53 (1999), Djavan, B., et al.: Expert Opin. Pharmacother., 6, 311 (2005),

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in ethanol (44 mg/ml), methanol (64 mg/ml), polyethylene glycol 400 (3 mg/ml), and DMSO (62 mg/ml at 25° C 117mM). Insoluble in water.
Storage :
Store at 4° C
Melting Point :
247-248° C
Boiling Point :
~620.3° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.52 (Predicted)
IC50 :
3 β-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase: IC50 >0.15 mM (Mycobacterium tuberculosis)
pK Values :
pKa: 13.32 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6918296
MDL Number :
MFCD00937869
Beilstein Registry :
7401530
SMILES :

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Certificate of Analysis

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Dutasteride (CAS 164656-23-9)  Product Citations

See how others have used Dutasteride (CAS 164656-23-9). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 25374915  Kosaka, T. et al. 2014. Am J Clin Exp Urol. 2: 136-44.

Citations 1 to 1 of 1 total

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. Dutasteride, sc-207600, is in white or off-white crystalline powder form.
Answered by: Chemical Support 4
Date published: 2019-01-24

por favor, cual es el mejor modo de disolver el Dutasteride para hacer un inyectable?

Asked by: María27
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Rated 5 out of 5 by from Alonso et al Alonso et al. (PubMed ID 26345405) used Dutasteride to inhibit 5 alpha-reductase to increase immunoreactivities in estrogen-receptor beta as well as the androgen receptor. -SCBT Publication Review
Date published: 2015-03-28
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