Krox-8 Inhibitors
Krox-8 inhibitors represent a class of chemical compounds designed to selectively target and interfere with the activity of Krox-8, a transcription factor or protein involved in gene regulation. Krox-8, also known as Egr4 (Early Growth Response 4), belongs to the Early Growth Response (Egr) family of transcription factors. These proteins play a crucial role in controlling gene expression in response to various cellular signals and environmental cues.
The primary mechanism of action for Krox-8 inhibitors typically involves their interaction with the Krox-8 protein or its associated molecules, leading to the modulation of gene expression. By inhibiting Krox-8, these compounds have the ability to affect the transcriptional regulation of genes under Krox-8's control, although the specific genes and pathways regulated by Krox-8 are still subjects of active investigation. Scientists studying Krox-8 inhibitors aim to elucidate the precise roles and functions of Krox-8 in gene regulation and cellular responses, contributing to our understanding of its significance within various physiological and pathological contexts. These inhibitors serve as valuable tools for advancing our knowledge of Krox-8 and its roles in gene expression. In this context, they contribute to expanding our understanding of the intricate world of transcription factors and their impact on gene regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Fostriecin | 87860-39-7 | sc-202160 | 50 µg | $260.00 | 9 | |
Fostriecin selectively inhibits protein phosphatase 2A (PP2A), potentially altering multiple signaling pathways and transcription factor activities. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Triptolide is known to inhibit the transcription of various genes by interfering with RNA polymerase II, potentially affecting transcription factor gene expression. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1 inhibits the BET family of bromodomain proteins, potentially altering the expression of genes regulated by these epigenetic readers, including transcription factors. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can modulate a variety of molecular targets, including transcription factors, potentially influencing their expression and activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is known to interact with multiple signaling pathways that can modulate transcription factor activity and gene expression. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $32.00 $210.00 $720.00 $1128.00 $2302.00 $3066.00 $5106.00 | 22 | |
Apigenin is reported to affect transcription factors by modulating protein kinases and signaling pathways that regulate gene expression. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin has been shown to influence transcription factor activity by modulating kinase pathways that affect cellular processes including gene expression. | ||||||
Pyrrolidinedithiocarbamic acid ammonium salt | 5108-96-3 | sc-203224 sc-203224A | 5 g 25 g | $32.00 $63.00 | 11 | |
PDTC is an inhibitor of NF-κB, a transcription factor that regulates the expression of many genes, and may indirectly influence other transcription factors. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
Bay 11-7082 is a selective inhibitor of NF-κB activation, which could also affect the expression of genes regulated by this transcription factor. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $260.00 $925.00 | 5 | |
C646 is a competitive inhibitor of the histone acetyltransferase p300, which is necessary for the acetylation of histones during gene transcription. | ||||||