Molecular structure of Pyrrolidinedithiocarbamic acid ammonium salt, CAS Number: 5108-96-3
Pyrrolidinedithiocarbamic acid ammonium salt (CAS 5108-96-3)
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Application:
Pyrrolidinedithiocarbamic acid ammonium salt is an NF kappa B inhibitor with antioxidant properties
CAS Number:
5108-96-3
Purity:
≥98%
Molecular Weight:
164.28
Molecular Formula:
C5H8NS2•NH4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Pyrrolidinedithiocarbamic acid (PDTC) ammonium salt, also known as Ammonium pyrrolidine-1-carbodithioate, is a potent inhibitor of NF kappaB (Nuclear Factor kappaB). Experiments show that micromolar amounts of Pyrrolidinedithiocarbamic acid (PDTC) ammonium salt suppress IL-1beta and completely inhibit the increase of nitric oxide synthase mRNA in response to IL-1beta. Further studies suggest that Pyrrolidinedithiocarbamic acid ammonium salt also displays metal-ion chelating and antioxidant characteristics. Pyrrolidinedithiocarbamic acid ammonium salt, a compound with versatility, has the ability to engage with an array of proteins and enzymes. Notably, it interacts with cytochrome P450 enzymes, exerting a regulatory influence on their functionality. It exhibits inhibitory effects on enzymes like cyclooxygenase and lipoxygenase.
Pyrrolidinedithiocarbamic acid ammonium salt (CAS 5108-96-3) References
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- Fibrous scaffolds potentiate the paracrine function of mesenchymal stem cells: A new dimension in cell-material interaction. | Su, N., et al. 2017. Biomaterials. 141: 74-85. PMID: 28667901
- Pyrrolidinedithiocarbamic Acid Ammonium Salt Inhibits Apoptosis and Phenotypic Transformation of Co-Culture of Myeloma Cells and Renal Tubular Epithelial Cells by Reducing the Secretion of Light Chain Protein. | Yu, X., et al. 2020. Iran J Public Health. 49: 2078-2086. PMID: 33708728
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- Simultaneous Monitoring of HOCl and Viscosity with Drug-Induced Pyroptosis in Live Cells and Acute Lung Injury. | Zhan, Z., et al. 2022. Anal Chem. 94: 12144-12151. PMID: 35998356
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Inhibitor of:
β-defensin 130, κB-Ras1, 2810408P10Rik, 4930432O21Rik, A630033E08Rik, ALKBH2, AOAH, ATF-3, ATP7A, Bacteroides LPS, C230078M08Rik, C8orf70, CARD 14, CARD 8, caspase-11, CLEC-2L, CLEC-4D, CLEC-6, COMMD3, Dab1, EG619597, EG636741, EG639396, EG666257, EG669998, FAM105B, G0S2, gasdermin A2, gasdermin A3, Grx2, GS2-like, GSDMC3, IκB-pp40, ICEBERG, IFIX, IFN-α10, IL-17B, IL-17R, IL-17RC, IL-18, IL-1F10, IL-1F7, IL-20, IL-28B, IL-32, IscU1, IscU2, Krox-8, KRTAP20-3, LCE1E, LCE2B, Ly6G6c, LYSMD4, MALL, MAN1C1, MANEAL, MD-1, MPP9, MRCL3, Mx2, MYH7B, NAIP2, NAIP7, NALP10, NALP13, NALP4A, NALP4C, NALP9, NALP9A, NF kappa B, NFκB p52, Nlrp12, Oxr1, p100, PLAA, PTP beta, Pyhin1, PYPAF7, RBJ, RelA, RFX-B, RNF24, SIMPL, SLC39A11, SUMF1, TALL-1, TBKBP1, TICAM-2, TL, TMC8, TMEM43, TMTSP, TMUB2, TNF Superfamily (TNFSF), TNFβ, TNIP2 (Abin-2), TRIM30A, TWEAK, VAT1L, ZFP1, ZFP64, ZIP2, ZNF202, ZNF205, ZNF256, ZNF589, ZNF598, ZNF654, ZNF682, ZNF683, ZNF701, ZNF708, ZNF800, ZnT-1, ZnT-5, and ZSWIM1.Activator of:
2610305D13Rik, 4732471D19Rik, CARD 6, CD79B, DTX3L, Dullard, FBXO4, FBXO6, Histone cluster 1 H3A, HIVEP1, hIws1, IκB-pp40, IRF-2BP2, KLF16, KLHL15, MAP-1B, MARCH8, Nek5, NFKBIL1, Nox4, Nrdp1, PSMD11, RNF151, RNF175, RNF182, RNF183, SBP Tag, SHARPIN, SLC39A13, Smt3, Tnfrsf26, Tom1, TRIM43C, TRIM50, TRIM7, UXT, WDR7, ZDHHC14, ZFP14, ZFP772, ZNF275, and ZNRF2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pyrrolidinedithiocarbamic acid ammonium salt, 5 g | sc-203224 | 5 g | $32.00 | |||
Pyrrolidinedithiocarbamic acid ammonium salt, 25 g | sc-203224A | 25 g | $63.00 |