KLHL38 Activators
Kelch-like protein 38 (KLHL38) remains a subject of intrigue due to its association with the complex and multifaceted ubiquitination process, where proteins are tagged for degradation or modulation. Activators or modulators of KLHL38, in this context, play a pivotal role in influencing the ubiquitination machinery, either by direct interaction or through collateral pathways.
For instance, MLN4924, a NEDD8-activating enzyme, disrupts the neddylation of Cullin proteins. This interruption in the neddylation process directly impacts Cullin-RING ligase activity, possibly influencing KLHL38's ubiquitin ligase functions, given its known partnership with Cullin-3. Similarly, by focusing on specific cellular signaling pathways and processes, other chemicals, like KN-93 and NSC 23766, modulate the activity of calcium/calmodulin-dependent protein kinase II and Rac1 GTPase, respectively. Both these entities, while not directly linked to KLHL38, play roles in protein trafficking and degradation, affecting the broader landscape in which KLHL38 operates. On the other hand, compounds like ZM-447439 and Purvalanol A target Aurora kinases and CDKs, respectively, essential entities intertwined with protein degradation and the cell cycle. Their action, therefore, can carve a niche influencing KLHL38's role within the protein ubiquitination circuit. Similarly, chemicals like BAPTA-AM, which targets intracellular calcium dynamics, emphasize the breadth of cellular processes that can intersect with KLHL38's operations. By chelating calcium, various signaling cascades and protein degradation mechanisms are affected, bringing KLHL38's role into focus. With such a diverse array of chemical activators, KLHL38's ubiquitination dynamics can be modulated, making it a focal point of cellular regulation and control. Understanding these activators, therefore, unravels a deeper comprehension of the ubiquitination process and KLHL38's pivotal role within it.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $280.00 | 1 | |
MLN4924 is a potent inhibitor of NEDD8-activating enzyme (NAE). By inhibiting NAE, MLN4924 disrupts the neddylation of Cullin proteins, a process crucial for Cullin-RING ligase activity. This can indirectly modulate KLHL38's ubiquitin ligase functions, given its association with Cullin-3. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
KN-93 inhibits calcium/calmodulin-dependent protein kinase II (CaMKII). Given that CaMKII can affect multiple cellular processes, including protein ubiquitination, it's possible that modulating CaMKII activity can influence KLHL38 functionality. | ||||||
Ciliobrevin D | 1370554-01-0 | sc-507482 | 10 mg | $413.00 | ||
Ciliobrevin D is a dynein ATPase inhibitor. Given that dynein plays a role in protein trafficking within the cell, its inhibition can affect the localization and function of proteins like KLHL38. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $32.00 $210.00 $720.00 $1128.00 $2302.00 $3066.00 $5106.00 | 22 | |
Apigenin is a flavonoid that affects various cellular pathways, including PI3K/AKT. Given the interplay between PI3K/AKT signaling and protein degradation mechanisms, modulating this pathway can influence KLHL38's activity within the ubiquitination process. | ||||||
Akt Inhibitor IV | 681281-88-9 | sc-203809 sc-203809A | 5 mg 25 mg | $173.00 $695.00 | 42 | |
Directly targets AKT, an essential protein in the PI3K/AKT pathway. Altering AKT activity affects numerous processes, potentially including protein ubiquitination dynamics. This might lead to changes in KLHL38's role in ubiquitination. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
ZM-447439 is an Aurora kinase inhibitor. Aurora kinases play roles in cell cycle regulation and protein ubiquitination. By inhibiting these kinases, KLHL38's ubiquitination processes might be influenced. | ||||||
EHop-016 | 1380432-32-5 | sc-497382 | 5 mg | $78.00 | ||
EHop-016 is a Rac1 GTPase inhibitor. Since Rac1 GTPase is involved in protein trafficking, inhibiting its activity could have downstream implications on KLHL38 and the ubiquitination pathways it influences. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
BAPTA-AM is an intracellular calcium chelator. By affecting calcium signaling, which influences various cellular processes including protein degradation, KLHL38's role in the ubiquitination process can be modulated. | ||||||
Purvalanol A | 212844-53-6 | sc-224244 sc-224244A | 1 mg 5 mg | $71.00 $291.00 | 4 | |
Purvalanol A is a potent CDK inhibitor. CDKs play roles in cell cycle regulation, which intertwines with protein degradation and ubiquitination. KLHL38's ubiquitin ligase functions might be affected through the modulation of these kinases. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
Gö 6983 is a broad-spectrum PKC inhibitor. Protein kinase C (PKC) isoforms can influence protein degradation processes, thus modulating PKC might impact KLHL38's ubiquitination activities. | ||||||