Molecular structure of Akt Inhibitor IV, CAS Number: 681281-88-9
Akt Inhibitor IV (CAS 681281-88-9)
See product citations (42)
Alternate Names:
5-(2-Benzothiazolyl)-3-ethyl-2-[2-(methylphenylamino)ethenyl]-1-phenyl-1H-benzimidazolium iodide
Application:
Akt Inhibitor IV is an Inhibitor of Akt protein kinase
CAS Number:
681281-88-9
Purity:
≥98%
Molecular Weight:
614.54
Molecular Formula:
C31H27N4S•I
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Akt Inhibitor IV is a compound that functions by specifically inhibiting the activity of the Akt protein kinase. This inhibition occurs through competitive binding to the ATP-binding site of Akt, preventing its phosphorylation and subsequent activation. By targeting Akt, this compound disrupts the signaling pathways involved in cell survival, proliferation, and metabolism. As a result, Akt Inhibitor IV plays a role in regulating cellular processes and has the potential to impact various cellular functions. Its mechanism of action involves interfering with the phosphorylation cascade that activates Akt, ultimately influencing downstream signaling pathways. This compound′s ability to modulate Akt activity makes it a valuable tool for investigating the molecular mechanisms underlying cell signaling and may have implications for understanding disease processes at the cellular level.
Akt Inhibitor IV (CAS 681281-88-9) References
- Infection of human cancer cells with myxoma virus requires Akt activation via interaction with a viral ankyrin-repeat host range factor. | Wang, G., et al. 2006. Proc Natl Acad Sci U S A. 103: 4640-5. PMID: 16537421
- The role of Akt signaling in oxidative stress mediates NF-kappaB activation in mild transient focal cerebral ischemia. | Song, YS., et al. 2008. J Cereb Blood Flow Metab. 28: 1917-26. PMID: 18628779
- Peripheral inflammation induces tumor necrosis factor dependent AMPA receptor trafficking and Akt phosphorylation in spinal cord in addition to pain behavior. | Choi, JI., et al. 2010. Pain. 149: 243-253. PMID: 20202754
- Akt signaling pathway: a target for radiosensitizing human malignant glioma. | Chautard, E., et al. 2010. Neuro Oncol. 12: 434-43. PMID: 20406894
- Activation of Nippostrongylus brasiliensis infective larvae is regulated by a pathway distinct from the hookworm Ancylostoma caninum. | Huang, SC., et al. 2010. Int J Parasitol. 40: 1619-28. PMID: 20654619
- Cellular stress-induced up-regulation of FMRP promotes cell survival by modulating PI3K-Akt phosphorylation cascades. | Jeon, SJ., et al. 2011. J Biomed Sci. 18: 17. PMID: 21314987
- Synthesis and biological evaluation of analogues of AKT (protein kinase B) inhibitor-IV. | Sun, Q., et al. 2011. J Med Chem. 54: 1126-39. PMID: 21319800
- Differential effects of Akt pathway inhibitors on IL-1β-induced protein phosphorylation in human fibroblast-like synoviocytes. | Tsuji, F., et al. 2012. J Recept Signal Transduct Res. 32: 22-8. PMID: 22185084
- Anticancer/antiviral agent Akt inhibitor-IV massively accumulates in mitochondria and potently disrupts cellular bioenergetics. | Meinig, JM. and Peterson, BR. 2015. ACS Chem Biol. 10: 570-6. PMID: 25415586
- TLR5 Activation through NF-κB Is a Neuroprotective Mechanism of Postconditioning after Cerebral Ischemia in Mice. | Jeong, J., et al. 2017. Exp Neurobiol. 26: 213-226. PMID: 28912644
- Glycine confers neuroprotection through PTEN/AKT signal pathway in experimental intracerebral hemorrhage. | Zhao, D., et al. 2018. Biochem Biophys Res Commun. 501: 85-91. PMID: 29698679
- Neuroprotective effects of rapamycin on spinal cord injury in rats by increasing autophagy and Akt signaling. | Li, XG., et al. 2019. Neural Regen Res. 14: 721-727. PMID: 30632514
- Hyperbaric oxygen relieves neuropathic pain through AKT/TSC2/mTOR pathway activity to induce autophagy. | Liu, YD., et al. 2019. J Pain Res. 12: 443-451. PMID: 30774414
- Endothelial-Dependent and Independent Vascular Relaxation Effect of Tetrahydropalmatine on Rat Aorta. | Zhou, ZY., et al. 2019. Front Pharmacol. 10: 336. PMID: 31057398
- Cryptosporidium parvum maintains intracellular survival by activating the host cellular EGFR-PI3K/Akt signaling pathway. | Yang, H., et al. 2023. Mol Immunol. 154: 69-79. PMID: 36621060
Inhibitor of:
2310002L09Rik, 4921501E09Rik, ACBD6, Akt, CLIC4, CRIP3, Daf2, DDX15, DEAH-box RNA-dependent NTPase (DHX), FAM129B, LIN-44, Rab 40AL, Ser/Thr Protein Kinase, and WTX.Activator of:
14-3-3 σ, FGF-16, HGFA, KLHL38, PAK5, Rab GDI β, RhebL1, Tctex1, and TINAGL1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Akt Inhibitor IV, 5 mg | sc-203809 | 5 mg | $173.00 | |||
Akt Inhibitor IV, 25 mg | sc-203809A | 25 mg | $695.00 |