Akt Inhibitor IV CAS: 681281-88-9
MF: C31H27N4S•I
MW: 614.54
An Inhibitor of Akt protein kinase.

Akt Inhibitor IV (CAS 681281-88-9)

Akt Inhibitor IV | CAS 681281-88-9 is rated 5.0 out of 5 by 1.
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Alternate Names: 5-(2-Benzothiazolyl)-3-ethyl-2-[2-(methylphenylamino)ethenyl]-1-phenyl-1H-benzimidazolium iodide
Application: Akt Inhibitor IV is an Inhibitor of Akt protein kinase
CAS Number: 681281-88-9
Purity: ≥98%
Molecular Weight: 614.54
Molecular Formula: C31H27N4S•I
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Akt Inhibitor IV Inhibits Akt protein kinase. Reports indicate that Akt inhibitor IV targets the ATP-binding site of a kinase upstream of AKT and downstream of PI3K. Akt inhibitor IV was observed to increase the sensitivity of glioma cells to radiaton.


References

1. Wang, G., et al. 2006. Proc. Natl. Acad. Sci. U.S.A. 103: 4640-4645. PMID: 16537421
2. Huang, S.C., et al. 2010. Int J Parasitol. PMID: 20654619
3. Chautard, E., et al. 2010. Neuro-oncology. 12: 434-443. PMID: 20406894
4. Choi, J.I., et al. 2010. Pain. 149: 243-253. PMID: 20202754
5. Jeon, S.J. et al. 2011. J. Biomed. Sci. 18 : 17. PMID: 21314987

Physical State :
Solid
Solubility :
Soluble in DMSO (≥10 mg/ml).
Storage :
Store at 4° C
IC50 :
Akt-mediated FOXO1a nuclear export: IC50 = 625 nM; cell proliferation: IC50 = <1.25 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD00570739
SMILES :
CC[N+]1=C(N(C2=C1C=C(C=C2)C3=NC4=CC=CC=C4S3)C5=CC=CC=C5)C=CN(C)C6=CC=CC=C6.[I-]

Download SDS (MSDS)

Certificate of Analysis

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Akt Inhibitor IV (CAS 681281-88-9)  Product Citations

See how others have used Akt Inhibitor IV (CAS 681281-88-9). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 37 total

PMID: # 34513006  Luo, H.|Liu, W.|Zhou, Y.|Jiang, X.|Liu, Y.|Yang, Q.|Shao, L.| et al. 2021. Regen Biomater. 8: rbab049.

PMID: # 34348595  Wei, R.|Li, X.|Wang, X.|Zhang, N.|Wang, Y.|Zhang, X.|Gong, P.|Li, J.| et al. 2021. Virulence. 12: 2017-2036.

PMID: # 30740096  Li, S.|Gong, P.|Zhang, N.|Li, X.|Tai, L.|Wang, X.|Yang, Z.|Yang, J.|Zhu, X.|Zhang, X.|Li, J.| et al. 2019. Front Microbiol. 10: 37.

PMID: # 29887521  Zhi, H.|Gong, FH.|Cheng, WL.|Zhu, K.|Chen, L.|Yao, Y.|Ye, X.|Zhu, XY.|Li, H.| et al. 2018. J Am Heart Assoc. 7:

PMID: # 29698679  Zhao, D.|Chen, J.|Zhang, Y.|Liao, HB.|Zhang, ZF.|Zhuang, Y.|Pan, MX.|Tang, JC.|Liu, R.|Lei, Y.|Wang, S.|Qin, XP.|Feng, YG.|Chen, Y.|Wan, Q.| et al. 2018. Biochem Biophys Res Commun. 501: 85-91.

PMID: # 28701722  Youn, HS.|Kim, TY.|Park, UH.|Moon, ST.|An, SJ.|Lee, YK.|Hwang, JT.|Kim, EJ.|Um, SJ.| et al. 2017. Sci Rep. 7: 5198.

PMID: # 28350788  Naito, S.|Makhov, P.|Astsaturov, I.|Golovine, K.|Tulin, A.|Kutikov, A.|Uzzo, RG.|Kolenko, VM.| et al. 2017. Br. J. Cancer. 116: 1203-1207.

PMID: # 28260004  Jia, Y.|Wang, HD.|Wang, Q.|Ding, H.|Wu, HM.|Pan, H.| et al. 2017. Oncol. Rep. 37: 2252-2260.

PMID: # 27756325  Cepeda, MA. et al. 2016. Mol. Cancer. 15: 65.

PMID: # 26992638  Sun, S.|Cheng, S.|Zhu, Y.|Zhang, P.|Liu, N.|Xu, T.|Sun, C.|Lv, Y.| et al. 2016. Gene. 584: 90-96.

Citations 1 to 10 of 37 total

How can I find its storing time, I even forget it , only today I got it again in our refrigerator

Asked by: Wilson
Thank you for your question. Please contact Technical Service by phone, (800)-457-3801 option 2, email &lt;[email protected]&gt;, or by live chat directly on our website, www.scbt.com for further assistance.
Answered by: Sen Li
Date published: 2022-06-08

Dear sir/madam, I am working at Maastricht University. Is it possible to buy a product (CAS: 681281-88-9) and pay in Netherlands then you ship it to Zagazig University in Egypt? How much would this cost? Thanks in advance, Regards, Mahmoud

Asked by: Elbatrik
Thank you for your question. Please contact your local distributor or technical service for further assistance.
Answered by: Tech Service
Date published: 2019-02-12

What is the meaning of &quot;a kinase upstream of AKT and downstream of PI3K&quot; ?

Asked by: two2igm05
Thank you for your question. Akt Inhibitor IV, sc-203809, inhibits Akt phosphorylation during the AKT/PKB signaling pathway after PI 3-K, but before Akt, activates the ATP binding site on the plasma membrane.
Answered by: Chemical Support 4
Date published: 2017-03-03
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Rated 5 out of 5 by from Jeon Jeon, SJ. et al. (PubMed 21314987) used product sc-203809 (Akt Inhibitor IV) to verify the role of the Akt pathway in the regulation of FMRP induction in HeLa cells. Akt Inhibitor decreased expression of Akt in a concentration dependent manner. They additionally used product sc-202048 (Akt Inhibitor VIII) and noted similar results. -SCBT Publication Review
Date published: 2015-01-12
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