KIAA0953 Activators
KIAA0953 Activators comprise a distinctive array of chemical compounds that indirectly augment the functional activity of KIAA0953 through various cellular signaling pathways. The group includes Forskolin, Ionomycin, and PMA, which respectively increase cAMP, raise intracellular calcium, and activate PKC, all leading to the phosphorylation of proteins that regulate KIAA0953 activity. Similar effects are observed with db-cAMP and Isoproterenol, which also raise cAMP levels and activate PKA, further enhancing KIAA0953's activity through phosphorylation. EGCG contributes to this enhancement by inhibiting various protein kinases, thus reducing competitive signaling and potentially amplifying the activity of pathways in which KIAA0953 participates. Moreover, the PI3K inhibitors LY294002 and Wortmannin could shift signaling dynamics to favor the activation of KIAA0953 through altered downstream kinase activity.
The modulation of KIAA0953's activity is also influenced by chemicals that affect phosphorylation states within the cell. Okadaic acid, by inhibiting protein phosphatases, maintains proteins in a phosphorylated state that can include those associated with KIAA0953, thereby enhancing its activity. Zinc Pyrithione, through its impact on metal ion homeostasis, and Curcumin, by modulating pathways such as NF-κB, further contribute to the activation of KIAA0953. These compounds collectively function to elevate the activity of KIAA0953 without directly altering its expression levels, instead working through the intricate network of cellular signaling to achieve functional upregulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin acts by increasing cyclic AMP (cAMP) levels, which activates protein kinase A (PKA). PKA can then phosphorylate various substrates, potentially including proteins that interact with or modify the activity of KIAA0953, thereby enhancing its function. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which may activate calcium-dependent protein kinases that could phosphorylate and activate proteins within the KIAA0953 pathway. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate proteins that are part of the KIAA0953 signaling cascade, thereby enhancing KIAA0953 activity. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $114.00 $175.00 $260.00 $362.00 $617.00 $1127.00 | ||
db-cAMP, a cell-permeable cAMP analog, activates PKA. PKA-mediated phosphorylation can enhance the activity of proteins that modulate KIAA0953 function. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is another calcium ionophore that can increase calcium levels in the cell, potentially activating proteins involved in KIAA0953's signaling pathway. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases cAMP levels, indirectly leading to the activation of PKA which may enhance KIAA0953 activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG inhibits various protein kinases, which may reduce competitive signaling and indirectly enhance the signaling pathways in which KIAA0953 is involved. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. By inhibiting PI3K, it may lead to alterations in downstream signaling pathways that could enhance the activity of KIAA0953. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor that could potentiate KIAA0953 activity through similar mechanisms as LY294002 by altering downstream signaling. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A, leading to increased phosphorylation levels of cellular proteins, which could include regulators of KIAA0953 function. | ||||||