ICAT Activators
ICAT Activators are a set of compounds that influence various cellular signaling pathways, indirectly necessitating the regulatory function of ICAT, particularly in its role of inhibiting β-catenin within the Wnt signaling pathway. Forskolin and IBMX both act to raise intracellular cAMP levels, which can enhance the activity of PKA. PKA, in turn, has the potential to phosphorylate proteins that interact with ICAT, leading to an increased functional necessity for ICAT in regulating β-catenin's activity. Similarly, compounds such as Epigallocatechin Gallate, Lithium Chloride, SB 216763, BIO, Chir 99021, PD 98059, LY294002, Rapamycin, U0126, and SP600125 modulate different kinases.
ICAT Activators are a set of compounds that influence various cellular signaling pathways, indirectly necessitating the regulatory function of ICAT, particularly in its role of inhibiting β-catenin within the Wnt signaling pathway. Forskolin and IBMX both act to raise intracellular cAMP levels, which can enhance the activity of PKA. PKA, in turn, has the potential to phosphorylate proteins that interact with ICAT, leading to an increased functional necessity for ICAT in regulating β-catenin's activity. Similarly, compounds such as Epigallocatechin Gallate, Lithium Chloride, SB 216763, BIO, Chir 99021, PD 98059, LY294002, Rapamycin, U0126, and SP600125 modulate different kinases and signaling molecules like GSK-3, MEK, PI3K, mTOR, and JNK, all of which can indirectly elevate the functional demand for ICAT in maintaining proper β-catenin signaling control. These activators, by stabilizing β-catenin through the inhibition of GSK-3 or altering other pathways that interact with β-catenin signaling, create a cellular environment where ICAT's inhibitory action on β-catenin becomes increasingly vital.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing levels of cAMP. Elevated cAMP can enhance ICAT via protein kinase A (PKA) activation, which in turn could phosphorylate proteins that interact with ICAT, affecting its ability to inhibit β-catenin, indirectly increasing β-catenin-mediated signaling. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a nonspecific inhibitor of phosphodiesterases, which degrade cAMP and cGMP. By preventing cAMP degradation, IBMX can enhance the activity of ICAT by sustaining PKA activity, which may affect ICAT interaction with β-catenin. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
This catechin inhibits multiple kinases, potentially altering signaling pathways that converge on the β-catenin destruction complex, where ICAT functions as an inhibitor of β-catenin. By modulating these pathways, Epigallocatechin Gallate can indirectly enhance ICAT's inhibitory effect on β-catenin. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits glycogen synthase kinase 3 (GSK-3), a kinase that phosphorylates β-catenin for degradation. Inhibition of GSK-3 can lead to the stabilization and accumulation of β-catenin, potentially increasing the requirement for ICAT function in β-catenin regulation. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $70.00 $198.00 | 18 | |
SB 216763 is another GSK-3 inhibitor. By inhibiting GSK-3, it can stabilize β-catenin levels, thereby enhancing the functional need for ICAT to regulate β-catenin's activity within the cell. | ||||||
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $57.00 $184.00 $867.00 | 10 | |
BIO is a specific GSK-3 inhibitor that can stabilize β-catenin, thus potentially increasing the interaction between ICAT and β-catenin, enhancing the regulatory role of ICAT. | ||||||
GSK-3 Inhibitor XVI | 252917-06-9 | sc-221691 sc-221691A | 5 mg 25 mg | $153.00 $520.00 | 4 | |
Chir 99021 is a potent GSK-3 inhibitor, leading to β-catenin stabilization. Enhanced β-catenin levels could necessitate increased ICAT function to maintain proper β-catenin signaling control. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 is a MEK inhibitor, which can affect the MAPK pathway. This alteration in MAPK signaling may indirectly increase the need for ICAT's role in inhibiting β-catenin, as MAPK can influence β-catenin's transcriptional activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor, which can influence β-catenin activity by altering AKT signaling. This may enhance the functional need for ICAT to control β-catenin's interaction with the cellular transcription machinery. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, which can affect β-catenin signaling by altering the cellular growth response. This could indirectly enhance the function of ICAT in regulating β-catenin's transcriptional activity. | ||||||