HPS-3 Inhibitors
HPS-3 inhibitors refer to a class of chemical compounds that target and inhibit the function of the Hermansky-Pudlak Syndrome 3 (HPS-3) protein, which is involved in intracellular trafficking processes. HPS-3 is one of several proteins associated with the biogenesis of lysosome-related organelles complex (BLOC) and plays a crucial role in regulating the trafficking of proteins and organelles within cells. Specifically, HPS-3 is implicated in the proper formation and function of cellular structures such as melanosomes, platelet dense granules, and lysosomes, which are essential for cellular homeostasis. HPS-3 inhibitors, by modulating the function of this protein, can potentially alter the dynamics of protein sorting and trafficking mechanisms in these organelles, leading to changes in cellular physiology and organelle biogenesis.
The mechanisms by which HPS-3 inhibitors interact with their target are thought to involve binding to key active sites or domains within the HPS-3 protein, which prevents its participation in the assembly of BLOC complexes. This disruption affects the downstream processes involved in vesicle formation, fusion, and cargo delivery, ultimately influencing the overall distribution of materials within the cell. HPS-3 inhibitors are valuable for studying the molecular underpinnings of vesicle-mediated transport, offering insights into how cellular compartments communicate and coordinate functions like pigmentation, secretion, and degradation of macromolecules. These compounds provide important tools for understanding the role of intracellular trafficking in maintaining cellular architecture and function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine could lead to the hypomethylation of the HPS3 gene's promoter region. If methylation normally suppresses gene expression, demethylation would be expected to downregulate HPS-3 production. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A may inhibit histone deacetylase activity, leading to an accumulation of acetylated histones. This alteration in the chromatin structure could result in the repression of HPS3 transcription if the gene is normally expressed following histone deacetylation. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib may block the degradation of ubiquitinated proteins, potentially causing an accumulation of misfolded proteins and inducing stress responses that could downregulate the transcription of various genes, including HPS3. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits the mTOR pathway, which might lead to a general decrease in cap-dependent mRNA translation, thereby potentially reducing HPS-3 protein synthesis. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
By binding to DNA, Actinomycin D could inhibit RNA polymerase and suppress the transcriptional elongation of the HPS3 gene, resulting in decreased mRNA production and subsequent lower levels of HPS-3 protein. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide could inhibit eukaryotic protein synthesis by preventing ribosomal translocation. This would lead to a decrease in the translation of HPS3 mRNA, reducing HPS-3 protein levels. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
α-Amanitin may specifically inhibit RNA polymerase II, potentially decreasing the transcription of the HPS3 gene and leading to reduced levels of HPS-3 protein. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
By increasing the pH within endosomes and lysosomes, Chloroquine could disrupt the normal trafficking and processing of cellular components, potentially leading to a decrease in HPS-3 protein expression if it relies on these pathways for stability or localization. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
5-Aza-2′-Deoxycytidine could induce DNA hypomethylation and reactivation of silenced genes. However, if the HPS3 gene is normally activated through methylation, Decitabine application could downregulate its expression. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Geldanamycin binds to Hsp90 and inhibits its chaperone activity. If Hsp90 is necessary for the stability or function of transcription factors that drive HPS3 expression, Geldanamycin could lead to the destabilization of these factors and consequent downregulation of HPS3 transcription. | ||||||