Date published: 2026-4-27

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HIV-1 RT Inhibitors

HIV-1 RT inhibitors belong to a class of organic compounds that specifically target the reverse transcriptase (RT) enzyme of the human immunodeficiency virus type 1 (HIV-1). This enzyme is essential for the virus's replication cycle, as it plays a critical role in converting the viral RNA genome into DNA, which is then integrated into the host cell's genome. HIV-1 RT inhibitors are designed to disrupt this crucial step in the virus's life cycle by inhibiting the activity of the reverse transcriptase enzyme. This class of inhibitors encompasses various subclasses, including nucleoside reverse transcriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs). NRTIs are structurally similar to natural nucleosides and are incorporated into the growing viral DNA chain, causing chain termination due to their lack of a 3' hydroxyl group. On the other hand, NNRTIs bind to a distinct allosteric site on the reverse transcriptase enzyme, leading to conformational changes that inhibit its catalytic activity. The development of HIV-1 RT inhibitors represents a significant advancement in the field of antiretroviral research and has contributed to a better understanding of HIV-1 replication dynamics.

Items 11 to 20 of 38 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Tenofovir-d6

1020719-94-1sc-220205
1 mg
$505.00
1
(1)

Tenofovir-d6 (CAS 1020719-94-1) functions as a suppressor of HIV-1 RT, a crucial enzyme curbing the replication of the virus, potentially interfering with its life cycle.

beta-Rubromycin

27267-70-5sc-204636
sc-204636A
1 mg
5 mg
$177.00
$712.00
(0)

β-Rubromycin (CAS 27267-70-5) acts as a deterrent to HIV-1 RT, a pivotal enzyme constraining the replication of the virus, potentially disrupting its life cycle.

Etravirine-13C3

1189671-48-4sc-218447
1 mg
$500.00
(0)

Etravirine-13C3 (CAS 1189671-48-4) functions as a blocker of HIV-1 RT, a key enzyme curbing the replication of the virus, potentially interfering with its life cycle.

3′-Deoxy-2′,3′-didehydrothymidine

3056-17-5sc-202420
25 mg
$111.00
(0)

3′-Deoxy-2′,3′-didehydrothymidine (CAS 3056-17-5) acts as a suppressor of HIV-1 RT, a vital enzyme constraining the replication of the virus, potentially disrupting its life cycle.

2′,3′-Dideoxyinosine

69655-05-6sc-205098
sc-205098A
1 mg
5 mg
$41.00
$149.00
(0)

This drug is converted to its active form inside cells and inhibits reverse transcription by chain termination.

gamma-Rubromycin

27267-71-6sc-364111
sc-364111A
1 mg
5 mg
$101.00
$540.00
(0)

Gamma-Rubromycin (CAS 27267-71-6) functions as a hindrance to HIV-1 RT, a pivotal enzyme constraining the replication of the virus, potentially disrupting its life cycle.

3′-Azido-3′-deoxythymidine

30516-87-1sc-203319
10 mg
$61.00
2
(1)

3′-Azido-3′-deoxythymidine (CAS 30516-87-1) acts as a suppressor of HIV-1 RT, a vital enzyme constraining the replication of the virus, potentially disrupting its life cycle.

Luzopeptin A

75580-37-9sc-202214
1 mg
$288.00
8
(1)

Luzopeptin A (CAS 75580-37-9) functions as a blocker of HIV-1 RT, a key enzyme curbing the replication of the virus, potentially interfering with its life cycle.

rac Efavirenz-d5

154598-52-4sc-219826
1 mg
$490.00
(0)

Rac Efavirenz-d5 (CAS 154598-52-4) acts as a deterrent to HIV-1 RT, a pivotal enzyme constraining the replication of the virus, potentially disrupting its life cycle.

Emtricitabine-13C,15N2

1217820-69-3sc-218303
500 µg
$663.00
(0)

Emtricitabine-13C,15N2 (CAS 1217820-69-3) functions as a suppressor of HIV-1 RT, a vital enzyme constraining the replication of the virus, potentially disrupting its life cycle.