Date published: 2026-4-27

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HIV-1 RT Inhibitors

HIV-1 RT inhibitors belong to a class of organic compounds that specifically target the reverse transcriptase (RT) enzyme of the human immunodeficiency virus type 1 (HIV-1). This enzyme is essential for the virus's replication cycle, as it plays a critical role in converting the viral RNA genome into DNA, which is then integrated into the host cell's genome. HIV-1 RT inhibitors are designed to disrupt this crucial step in the virus's life cycle by inhibiting the activity of the reverse transcriptase enzyme. This class of inhibitors encompasses various subclasses, including nucleoside reverse transcriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs). NRTIs are structurally similar to natural nucleosides and are incorporated into the growing viral DNA chain, causing chain termination due to their lack of a 3' hydroxyl group. On the other hand, NNRTIs bind to a distinct allosteric site on the reverse transcriptase enzyme, leading to conformational changes that inhibit its catalytic activity. The development of HIV-1 RT inhibitors represents a significant advancement in the field of antiretroviral research and has contributed to a better understanding of HIV-1 replication dynamics.

Items 21 to 30 of 38 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

nPOC-POC Tenofovir

sc-219420
1 mg
$480.00
(0)

nPOC-POC Tenofovir acts as a suppressor of HIV-1 RT, a pivotal enzyme curbing the replication of the virus, potentially disrupting its life cycle.

Stavudine-d3

sc-220133
1 mg
$380.00
(0)

Stavudine-d3 acts as a blocker of HIV-1 RT, a key enzyme constraining the replication of the virus, potentially interfering with its life cycle.

Tenofovir Monohydrate

206184-49-8sc-394169
100 mg
$123.00
(0)

Tenofovir Monohydrate acts as a suppressor of HIV-1 RT, a vital enzyme constraining the replication of the virus, potentially disrupting its life cycle.

Rilpivirine

500287-72-9sc-477396
sc-477396A
2.5 mg
10 mg
$451.00
$565.00
(0)

Rilpivirine is a newer NNRTI that binds to the hydrophobic pocket of RT, preventing viral RNA from being converted into DNA.

Abacavir hydrochloride

136470-78-5 (non-salt)sc-358732
sc-358732A
1 g
5 g
$200.00
$500.00
1
(0)

Abacavir hydrochloride (CAS 136470-78-5, non-salt) functions as a hindrance to HIV-1 RT, a crucial enzyme constraining the replication of the virus, potentially disrupting its life cycle.

Nevirapine

129618-40-2sc-208092
5 mg
$99.00
5
(1)

Nevirapine (CAS 129618-40-2) is a potent HIV-1 RT inhibitor, targeting the enzyme crucial for viral replication, thus impeding the virus's ability to proliferate.

Hexaprenylhydroquinone

119980-00-6sc-202648
1 mg
$114.00
(0)

Hexaprenylhydroquinone (CAS 119980-00-6) acts as an HIV-1 RT inhibitor, disrupting the enzyme's function crucial for viral replication, thus hampering virus multiplication.

4-Chloro-2-(trifluoroacetyl)aniline hydrochloride

173676-59-0sc-206339
1 g
$130.00
(0)

4-Chloro-2-(trifluoroacetyl)aniline hydrochloride (CAS 173676-59-0) functions as an HIV-1 RT inhibitor, disrupting the enzyme's role vital for viral replication, thus impeding virus proliferation

Etravirine-d6

269055-15-4sc-218448
1 mg
$440.00
(0)

Etravirine-d6 (CAS 269055-15-4) acts as an HIV-1 RT inhibitor, interfering with the enzyme's function crucial for viral replication, thereby hindering virus multiplication.

Efavirenz

154598-52-4sc-207612
10 mg
$171.00
3
(1)

Efavirenz (CAS 154598-52-4) functions as an HIV-1 RT inhibitor, disrupting the enzyme's role vital for viral replication, thereby impeding virus proliferation.