Date published: 2026-4-27

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HIV-1 RT Inhibitors

HIV-1 RT inhibitors belong to a class of organic compounds that specifically target the reverse transcriptase (RT) enzyme of the human immunodeficiency virus type 1 (HIV-1). This enzyme is essential for the virus's replication cycle, as it plays a critical role in converting the viral RNA genome into DNA, which is then integrated into the host cell's genome. HIV-1 RT inhibitors are designed to disrupt this crucial step in the virus's life cycle by inhibiting the activity of the reverse transcriptase enzyme. This class of inhibitors encompasses various subclasses, including nucleoside reverse transcriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs). NRTIs are structurally similar to natural nucleosides and are incorporated into the growing viral DNA chain, causing chain termination due to their lack of a 3' hydroxyl group. On the other hand, NNRTIs bind to a distinct allosteric site on the reverse transcriptase enzyme, leading to conformational changes that inhibit its catalytic activity. The development of HIV-1 RT inhibitors represents a significant advancement in the field of antiretroviral research and has contributed to a better understanding of HIV-1 replication dynamics.

Items 1 to 10 of 38 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Tenofovir

147127-20-6sc-204335
sc-204335A
10 mg
50 mg
$157.00
$646.00
11
(1)

Tenofovir (CAS 147127-20-6) is a compound that hinders HIV-1 RT, a key enzyme in the replication of the HIV-1 virus, potentially disrupting its lifecycle.

Tenofovir Disoproxil Fumarate

202138-50-9sc-208420
10 mg
$190.00
2
(1)

Tenofovir Disoproxil Fumarate (CAS 202138-50-9) acts as an impediment to HIV-1 RT, a pivotal enzyme curbing the replication of the virus, potentially interfering with its life cycle.

AMI-1, sodium salt

20324-87-2sc-205928
sc-205928A
5 mg
25 mg
$114.00
$398.00
2
(1)

AMI-1, sodium salt (CAS 20324-87-2), acts as a hindrance to HIV-1 RT, a crucial enzyme restraining the replication of the virus, potentially disrupting its life cycle.

Abacavir Sulfate

188062-50-2sc-207238
sc-207238A
5 mg
25 mg
$146.00
$244.00
(1)

Abacavir Sulfate (CAS 188062-50-2) functions as a deterrent to HIV-1 RT, a pivotal enzyme impeding the replication of the virus, potentially interrupting its life cycle.

Emtricitabine

143491-57-0sc-207617
10 mg
$152.00
1
(1)

Emtricitabine (CAS 143491-57-0) acts as a suppressor of HIV-1 RT, a crucial enzyme constraining the replication of the virus, potentially disrupting its life cycle.

Etravirine

269055-15-4sc-207674
5 mg
$180.00
2
(1)

Etravirine (CAS 269055-15-4) functions as a blocker of HIV-1 RT, a key enzyme curbing the replication of the virus, potentially interfering with its life cycle.

AMI-1, free acid

134-47-4sc-300192
1 g
$98.00
(0)

AMI-1, free acid (CAS 134-47-4), acts as a suppressor of HIV-1 RT, a crucial enzyme impeding the replication of the virus, potentially disrupting its life cycle.

Lamivudine

134678-17-4sc-221830
sc-221830A
10 mg
50 mg
$104.00
$218.00
1
(2)

Lamivudine (CAS 134678-17-4) acts as a deterrent to HIV-1 RT, a vital enzyme curbing the replication of the virus, potentially interfering with its life cycle.

2′,3′-Dideoxycytidine

7481-89-2sc-205579
sc-205579A
100 mg
250 mg
$154.00
$333.00
(1)

2',3'-Dideoxycytidine (CAS 7481-89-2) acts as a hindrance to HIV-1 RT, a key enzyme constraining the replication of the virus, potentially disrupting its life cycle.

Ziagen

136470-78-5sc-338739
sc-338739A
1 g
5 g
$130.00
$400.00
1
(0)

This NRTI is metabolized intracellularly to its active form and competes with natural nucleotides, leading to chain termination during reverse transcription.